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Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R. Gaubitz C, et al. Among authors: prouteau m. Mol Cell. 2015 Jun 18;58(6):977-88. doi: 10.1016/j.molcel.2015.04.031. Epub 2015 May 28. Mol Cell. 2015. PMID: 26028537 Free article.
TORC2 Structure and Function.
Gaubitz C, Prouteau M, Kusmider B, Loewith R. Gaubitz C, et al. Among authors: prouteau m. Trends Biochem Sci. 2016 Jun;41(6):532-545. doi: 10.1016/j.tibs.2016.04.001. Epub 2016 May 5. Trends Biochem Sci. 2016. PMID: 27161823 Review.
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R. Prouteau M, et al. Nature. 2017 Oct 12;550(7675):265-269. doi: 10.1038/nature24021. Epub 2017 Oct 4. Nature. 2017. PMID: 28976958 Free PMC article.
TOR Signaling Is Going through a Phase.
Prouteau M, Loewith R. Prouteau M, et al. Cell Metab. 2019 May 7;29(5):1019-1021. doi: 10.1016/j.cmet.2019.04.010. Cell Metab. 2019. PMID: 31067446 Free article.
EGOC inhibits TOROID polymerization by structurally activating TORC1.
Prouteau M, Bourgoint C, Felix J, Bonadei L, Sadian Y, Gabus C, Savvides SN, Gutsche I, Desfosses A, Loewith R. Prouteau M, et al. Nat Struct Mol Biol. 2023 Mar;30(3):273-285. doi: 10.1038/s41594-022-00912-6. Epub 2023 Jan 26. Nat Struct Mol Biol. 2023. PMID: 36702972 Free PMC article.
31 results