Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2004 2
2006 2
2007 1
2008 2
2010 2
2011 2
2014 3
2015 3
2016 2
2017 2
2019 8
2020 6
2021 2
2022 4
2023 3
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

47 results

Results by year

Filters applied: . Clear all
Page 1
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Ni F, Yu WM, Wang X, Fay ME, Young KM, Qiu Y, Lam WA, Sulchek TA, Cheng T, Scadden DT, Qu CK. Ni F, et al. Cell Stem Cell. 2019 Apr 4;24(4):608-620.e6. doi: 10.1016/j.stem.2019.02.009. Epub 2019 Mar 14. Cell Stem Cell. 2019. PMID: 30880025 Free PMC article.
Ptpn21(-/-) HSCs exhibit enhanced mobility, decreased quiescence, increased apoptosis, and defective reconstitution capacity. ...Elevated phosphorylation of Spetin1 in Ptpn21(-/-) cells impaired cytoskeletal remodeling, contributed to cortical instability, and decre …
Ptpn21(-/-) HSCs exhibit enhanced mobility, decreased quiescence, increased apoptosis, and defective reconstitution capacity. ...Elev …
Prognostic value and immunological role of PTPN21 in pan-cancer analysis.
Yang Y, Yang W, Su X, Cheng C. Yang Y, et al. Cent Eur J Immunol. 2023;48(2):111-125. doi: 10.5114/ceji.2023.129970. Epub 2023 Jul 20. Cent Eur J Immunol. 2023. PMID: 37692032 Free PMC article.
In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship between PTPN21 and immune infiltration. ...PTPN21 may be a potential biomarker for many cancers, especially in KIRC....
In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship b …
PTPN21-CDS(long) isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis.
Wang H, Zhu N, Ye X, Wang L, Wang B, Shan W, Lai X, Tan Y, Fu S, Xiao H, Huang H. Wang H, et al. J Cell Biochem. 2020 Jun;121(5-6):3298-3312. doi: 10.1002/jcb.29601. Epub 2020 Jan 2. J Cell Biochem. 2020. PMID: 31898344
PTPN21 consists of three types of isoforms according to the length of the protein encoded. ...The results showed that there was no significant change when all PTPN21 isoforms were knocked out in ALL cells, but the sensitivity of NALM6 cells with PTPN21-CDS(lo …
PTPN21 consists of three types of isoforms according to the length of the protein encoded. ...The results showed that there was no si …
Inhibition of PTPN21 has antitumor effects in glioma by restraining the EGFR/PI3K/AKT pathway.
Li XQ, Liu BC, Jiang XB, Gao WW, Rong B, Wei Y, Wang FL, Zhao HK, Zhang L. Li XQ, et al. Toxicol Appl Pharmacol. 2022 Sep 15;451:116180. doi: 10.1016/j.taap.2022.116180. Epub 2022 Jul 27. Toxicol Appl Pharmacol. 2022. PMID: 35907586
However, the correlation between PTPN21 and glioma remains unaddressed. This investigation focused on the relevance of PTPN21 in glioma. ...Reactivation of AKT reversed PTPN21 silencing-evoked antitumor effect. The tumorigenic potential of PTPN21-silen …
However, the correlation between PTPN21 and glioma remains unaddressed. This investigation focused on the relevance of PTPN21 …
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
Siddiqui N, Zwetsloot AJ, Bachmann A, Roth D, Hussain H, Brandt J, Kaverina I, Straube A. Siddiqui N, et al. Nat Commun. 2019 Jun 19;10(1):2693. doi: 10.1038/s41467-019-10644-9. Nat Commun. 2019. PMID: 31217419 Free PMC article.
We show that the microtubule binding surface of KIF1C motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21. The FERM domain of PTPN21 stimulates dense core vesicle transport …
We show that the microtubule binding surface of KIF1C motor domain interacts with its stalk and that these autoinhibitory interactions are r …
PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.
Plani-Lam JH, Chow TC, Siu KL, Chau WH, Ng MH, Bao S, Ng CT, Sham P, Shum DK, Ingley E, Jin DY, Song YQ. Plani-Lam JH, et al. Int J Biochem Cell Biol. 2015 Apr;61:53-62. doi: 10.1016/j.biocel.2015.02.003. Epub 2015 Feb 11. Int J Biochem Cell Biol. 2015. PMID: 25681686
Conversely, kinase-dead ErbB4 (K751R) or phosphatase-dead PTPN21 (C1108S) mutants impede PTPN21-dependent signaling. Furthermore, PTPN21 also induced Elk-1 activation in embryonic cortical neurons and a novel Elk-1 binding motif was identified in a region loc …
Conversely, kinase-dead ErbB4 (K751R) or phosphatase-dead PTPN21 (C1108S) mutants impede PTPN21-dependent signaling. Furthermo …
PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo.
Campbell JS, Davidson AJ, Todd H, Rodrigues FSLM, Elliot AM, Early JJ, Lyons DA, Feng Y, Wood W. Campbell JS, et al. Curr Biol. 2021 Feb 22;31(4):875-883.e5. doi: 10.1016/j.cub.2020.11.014. Epub 2020 Dec 8. Curr Biol. 2021. PMID: 33296680 Free PMC article.
We show that this key role is conserved in vertebrates, because "crispant" zebrafish larvae of the Draper ortholog (MEGF10) or the Pez ortholog (PTPN21) exhibit a failure in leukocyte recruitment to wounds. This study demonstrates evolutionary conservation of inflammatory …
We show that this key role is conserved in vertebrates, because "crispant" zebrafish larvae of the Draper ortholog (MEGF10) or the Pez ortho …
PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function.
Wang H, Ye X, Xiao H, Zhu N, Wei C, Sun X, Wang L, Wang B, Yu X, Lai X, Fu S, Huang H. Wang H, et al. Stem Cells Int. 2019 Nov 21;2019:4686132. doi: 10.1155/2019/4686132. eCollection 2019. Stem Cells Int. 2019. PMID: 31885609 Free PMC article.
However, the role of PTPN21 in the bone marrow microenvironment has not yet been elucidated. In the study, we explored the effects of PTPN21 on human bone marrow-derived mesenchymal stem cells (BM-MSCs) via lentiviral-mediated overexpression and knock-down of PTP …
However, the role of PTPN21 in the bone marrow microenvironment has not yet been elucidated. In the study, we explored the effects of …
PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.
Cui N, Lu H, Li M, Yan Q. Cui N, et al. Eur J Pharmacol. 2017 Nov 5;814:226-231. doi: 10.1016/j.ejphar.2017.08.021. Epub 2017 Aug 24. Eur J Pharmacol. 2017. PMID: 28843827
Nevertheless, it is not clear whether PTPN21 plays a role in hypoxia ischemia-induced neuronal injury. A proper understanding of the PTPN21 mechanism in neuron growth regulation is limited. In this study, we investigated the neuroprotective effects and potential mec …
Nevertheless, it is not clear whether PTPN21 plays a role in hypoxia ischemia-induced neuronal injury. A proper understanding of the …
Overexpression of PTPN21 promotes proliferation of EGF-stimulated acute lymphoblastic leukemia cells via the MAPK signaling pathways.
Zhu N, Wei J, Wang LM, Huang H, Xiao H. Zhu N, et al. Hematology. 2024 Dec;29(1):2356292. doi: 10.1080/16078454.2024.2356292. Epub 2024 May 24. Hematology. 2024. PMID: 38785187
METHODS: PTPN21 was overexpressed in ALL cell lines by lentiviral transfection. ...Inhibition of MAPK pathways by specific inhibitors mitigated this pro-proliferative effect of excessive PTPN21 on EGF-stimulated ALL cells. CONCLUSION: PTPN21 may facilitate AL …
METHODS: PTPN21 was overexpressed in ALL cell lines by lentiviral transfection. ...Inhibition of MAPK pathways by specific inhibitors …
47 results