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PTPN4 germline variants result in aberrant neurodevelopment and growth.
Chmielewska JJ, Burkardt D, Granadillo JL, Slaugh R, Morgan S, Rotenberg J, Keren B, Mignot C, Escobar L, Turnpenny P, Zuteck M, Seaver LH, Ploski R, Dziembowska M, Wynshaw-Boris A, Adegbola A. Chmielewska JJ, et al. HGG Adv. 2021 Jul 8;2(3):100033. doi: 10.1016/j.xhgg.2021.100033. Epub 2021 Apr 5. HGG Adv. 2021. PMID: 34527963 Free PMC article.
Using exome sequencing, we identified missense and truncating variants in PTPN4 in six unrelated individuals with varying degrees of intellectual disability or developmental delay. ...We suggest that pathogenic variants in PTPN4 confer risk for growth and cognitive …
Using exome sequencing, we identified missense and truncating variants in PTPN4 in six unrelated individuals with varying degrees of …
PTPN4 negatively regulates CrkI in human cell lines.
Zhou J, Wan B, Shan J, Shi H, Li Y, Huo K. Zhou J, et al. Cell Mol Biol Lett. 2013 Jun;18(2):297-314. doi: 10.2478/s11658-013-0090-3. Epub 2013 May 15. Cell Mol Biol Lett. 2013. PMID: 23666597 Free PMC article.
PTPN4 is a widely expressed non-receptor protein tyrosine phosphatase. ...We further determined the interactional regions as the SH3 domain of CrkI and the proline-rich region between amino acids 462 and 468 of PTPN4. Notably, overexpression of PTPN4 inhibits …
PTPN4 is a widely expressed non-receptor protein tyrosine phosphatase. ...We further determined the interactional regions as the SH3 …
Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization.
Wang F, Jiang M, Chi Y, Huang G, Jin M. Wang F, et al. Mol Cell Biochem. 2023 Aug 26. doi: 10.1007/s11010-023-04824-x. Online ahead of print. Mol Cell Biochem. 2023. PMID: 37632638
The results showed that circRNA-Ptpn4 was highly expressed during hypoxia pretreatment of ADSCs exosomes. Exosomes from circ-Ptpn4-modified ADSCs had a greater ability to promote functional recovery. ...
The results showed that circRNA-Ptpn4 was highly expressed during hypoxia pretreatment of ADSCs exosomes. Exosomes from circ-Ptpn4 …
miR-16-5p Regulates PTPN4 and Affects Cardiomyocyte Apoptosis and Autophagy Induced by Hypoxia/Reoxygenation.
Cao Z, Liu J, Zhao Z, Wang Q. Cao Z, et al. Evid Based Complement Alternat Med. 2021 Jun 16;2021:5599031. doi: 10.1155/2021/5599031. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34306144 Free PMC article.
METHODS: AC16 cells were divided into the control group (NC), hypoxia/reoxygenation group (H/R), knockdown miR-16-5p negative control group (NC inhibitor), knockdown miR-16-5p group (miR-16-5p inhibitor), overexpression miR-16-5p negative control group (NC mimics), overexpression …
METHODS: AC16 cells were divided into the control group (NC), hypoxia/reoxygenation group (H/R), knockdown miR-16-5p negative control group …
MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis.
Gan J, Liu S, Zhang Y, He L, Bai L, Liao R, Zhao J, Guo M, Jiang W, Li J, Li Q, Mu G, Wu Y, Wang X, Zhang X, Zhou D, Lv H, Wang Z, Zhang Y, Qian C, Feng M, Chen H, Meng Q, Huang X. Gan J, et al. Exp Mol Med. 2022 Aug;54(8):1290-1305. doi: 10.1038/s12276-022-00837-6. Epub 2022 Aug 30. Exp Mol Med. 2022. PMID: 36042375 Free PMC article.
Mechanistically, miR-375 directly interfered with the expression of phosphatase nonreceptor type 4 (PTPN4), which in turn stabilized phosphorylated STAT3. Application of e-375i could inhibit miR-375, upregulate PTPN4 and downregulate p-STAT3, eventually repressing t …
Mechanistically, miR-375 directly interfered with the expression of phosphatase nonreceptor type 4 (PTPN4), which in turn stabilized …
The correlation of PTPN4 expression with prognosis in breast cancer.
Wang D, Wang S, Chen L, He D, Han S, Huang B, Fu W. Wang D, et al. Int J Clin Exp Pathol. 2018 Oct 1;11(10):4845-4853. eCollection 2018. Int J Clin Exp Pathol. 2018. PMID: 31949559 Free PMC article.
In our study, data from 140 invasive breast cancer patients were retrospectively collected to identify the association between PTPN4 expression and clinical outcomes of these patients. The expressions of PTPN4 were detected by immunohistochemical analysis. Breast hy …
In our study, data from 140 invasive breast cancer patients were retrospectively collected to identify the association between PTPN4 …
Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.
Zhang BD, Li YR, Ding LD, Wang YY, Liu HY, Jia BQ. Zhang BD, et al. Cancer Sci. 2019 Jul;110(7):2258-2272. doi: 10.1111/cas.14031. Epub 2019 May 23. Cancer Sci. 2019. PMID: 31025789 Free PMC article.
In this study, we identified a nonsense mutation of PTPN4 with a mutation ratio of 90.90% from 1 case of rectal cancer, leading to loss of function in PTPN4 gene. ...Overexpression of PTPN4 suppressed the cell growth, and moreover, the loss of PTPN4 ac …
In this study, we identified a nonsense mutation of PTPN4 with a mutation ratio of 90.90% from 1 case of rectal cancer, leading to lo …
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro.
Tang Y, Yang H, Yu J, Li Z, Xu Q, Ding B, Jia G. Tang Y, et al. Toxicol Appl Pharmacol. 2022 Feb 15;437:115892. doi: 10.1016/j.taap.2022.115892. Epub 2022 Jan 25. Toxicol Appl Pharmacol. 2022. PMID: 35085590
Luciferase reporter assay validated the direct interaction between miR-34a-5p and PTPN4. Crocin upregulated PTPN4 by decreasing miR-34a-5p expression in PTC cells. Crocin promoted apoptosis and increased caspase-3 activity and LDH release, which were reversed by ROS …
Luciferase reporter assay validated the direct interaction between miR-34a-5p and PTPN4. Crocin upregulated PTPN4 by decreasin …
Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
Huai W, Song H, Wang L, Li B, Zhao J, Han L, Gao C, Jiang G, Zhang L, Zhao W. Huai W, et al. J Immunol. 2015 May 1;194(9):4458-65. doi: 10.4049/jimmunol.1402183. Epub 2015 Mar 30. J Immunol. 2015. PMID: 25825441
Consequently, PTPN4 specifically inhibits TRIF-dependent IRF3 activation and IFN-beta production in TLR4 pathway. Therefore, our results provide new insight into the TLR4 pathway and identify PTPN4 as a specific inhibitor of TRIF-dependent TLR4 pathway. Targeting …
Consequently, PTPN4 specifically inhibits TRIF-dependent IRF3 activation and IFN-beta production in TLR4 pathway. Therefore, our resu …
miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4.
Ge L, Cai Y, Ying F, Liu H, Zhang D, He Y, Pang L, Yan D, Xu A, Ma H, Xia Z. Ge L, et al. Oxid Med Cell Longev. 2019 Apr 17;2019:1957920. doi: 10.1155/2019/1957920. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31178952 Free PMC article.
The overexpression of miR-181c-5p significantly attenuated the mRNA and protein expression of PTPN4 in H9C2 cardiomyocytes. Moreover, knockdown of PTPN4 significantly aggravated H/R-induced enhancement of LDH level, cleaved caspase 3 expression, and apoptotic cell d …
The overexpression of miR-181c-5p significantly attenuated the mRNA and protein expression of PTPN4 in H9C2 cardiomyocytes. Moreover, …
56 results