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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1962 1
1963 1
1965 1
1967 1
1968 1
1969 2
1971 1
1973 5
1974 1
1975 8
1976 5
1977 5
1978 4
1979 6
1980 12
1981 15
1982 16
1983 28
1984 19
1985 38
1986 31
1987 32
1988 23
1989 44
1990 41
1991 49
1992 65
1993 69
1994 57
1995 69
1996 81
1997 76
1998 85
1999 78
2000 101
2001 102
2002 98
2003 101
2004 102
2005 114
2006 102
2007 89
2008 120
2009 133
2010 146
2011 166
2012 157
2013 154
2014 196
2015 181
2016 222
2017 223
2018 262
2019 222
2020 281
2021 342
2022 324
2023 301
2024 137

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4,802 results

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Page 1
RNA Editing of Serotonin 2C Receptor and Alcohol Intake.
Tanaka M, Watanabe Y. Tanaka M, et al. Front Neurosci. 2020 Jan 14;13:1390. doi: 10.3389/fnins.2019.01390. eCollection 2019. Front Neurosci. 2020. PMID: 32009879 Free PMC article. Review.
Serotonin 2C receptor (5-HT(2) (C)R) belongs to the superfamily of seven transmembrane domain receptors coupled to G proteins (GPCR). ...Here, we review 5-HT(2) (C)R and its relationship with alcohol intake with a particular focus on the involvement of 5-HT(2) (C) …
Serotonin 2C receptor (5-HT(2) (C)R) belongs to the superfamily of seven transmembrane domain receptors coupled to G proteins (GPCR). …
Axial chirality and affinity at the GABAA receptor of triazolobenzodiazepines.
Tanaka R, Makino K, Tabata H, Oshitari T, Natsugari H, Takahashi H. Tanaka R, et al. Bioorg Med Chem. 2022 Jun 15;64:116758. doi: 10.1016/j.bmc.2022.116758. Epub 2022 Apr 18. Bioorg Med Chem. 2022. PMID: 35472555
The atropisomers of 1,10-disubstituted triazolobenzodiazepines, 1d and 1f, were isolated as (a(1)R, a(2)S) and (a(1)S, a(2)R) isomers. Their absolute configurations were determined on the basis of CD spectra in comparison with those of stereochemically defined 9-met …
The atropisomers of 1,10-disubstituted triazolobenzodiazepines, 1d and 1f, were isolated as (a(1)R, a(2)S) and (a(1)S, a(2)R) …
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.
Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S, Shimamura T. Im D, et al. Among authors: tanaka t. Nat Commun. 2020 Dec 22;11(1):6442. doi: 10.1038/s41467-020-20221-0. Nat Commun. 2020. PMID: 33353947 Free PMC article.
The inactive state structures of D(2)R have been described in complex with the inverse agonists risperidone (D(2)R(ris)) and haloperidol (D(2)R(hal)). Here we describe the structure of human D(2)R in complex with spiperone (D(2)R(spi)). In D(2) …
The inactive state structures of D(2)R have been described in complex with the inverse agonists risperidone (D(2)R(ris)) and h …
Modulation of P2Y(6)R expression exacerbates pressure overload-induced cardiac remodeling in mice.
Shimoda K, Nishimura A, Sunggip C, Ito T, Nishiyama K, Kato Y, Tanaka T, Tozaki-Saitoh H, Tsuda M, Nishida M. Shimoda K, et al. Among authors: tanaka t. Sci Rep. 2020 Aug 18;10(1):13926. doi: 10.1038/s41598-020-70956-5. Sci Rep. 2020. PMID: 32811872 Free PMC article.
In neonatal cardiomyocytes, knockdown of P2Y(6)R significantly attenuated hypertrophic growth and cell death caused by hypotonic stimulation, indicating the involvement of P2Y(6)R in mechanical stress-induced myocardial dysfunction. ...These findings provide overwhe …
In neonatal cardiomyocytes, knockdown of P2Y(6)R significantly attenuated hypertrophic growth and cell death caused by hypotonic stim …
Low Genetic Polymorphism in the Immunogenic Sequences of Rhipicephalus microplus Clade C.
Zeb I, Almutairi MM, Alouffi A, Islam N, Parizi LF, Safi SZ, Tanaka T, da Silva Vaz I Jr, Ali A. Zeb I, et al. Among authors: tanaka t. Vaccines (Basel). 2022 Nov 11;10(11):1909. doi: 10.3390/vaccines10111909. Vaccines (Basel). 2022. PMID: 36423005 Free PMC article.
In the phylogenetic trees, the cystatin 2b, cathepsin-L, ferritin 1, and aquaporin 2 sequences were clustered with the most similar available sequences of R. microplus, P0 with R. microplus, R. sanguineus and R. haemaphysaloides, and GST, ATAQ, and Rm0 …
In the phylogenetic trees, the cystatin 2b, cathepsin-L, ferritin 1, and aquaporin 2 sequences were clustered with the most similar availabl …
Usefulness of Shoulder36 in rotator cuff tears: Comparison with Simple Shoulder Test.
Kawakami J, Gotoh M, Matsuura K, Shin K, Fujito I, Tanaka A, Matsunaga S, Imai T, Nagamatsu T, Karasuyama M, Ohota T, Madokoro K, Shiba N. Kawakami J, et al. Among authors: tanaka a. J Orthop Surg (Hong Kong). 2019 Jan-Apr;27(1):2309499018819060. doi: 10.1177/2309499018819060. J Orthop Surg (Hong Kong). 2019. PMID: 30798742 Free article.

The correlation coefficient between the JOA and each domain in Sh36 was as follows: r = 0.76 (vs. pain, p < 0.01); r = 0.73 (vs. range of motion, p < 0.01); r = 0.78 (vs. muscle strength, p < 0.01); r = 0.68 (vs. general health, p < 0.01);

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The correlation coefficient between the JOA and each domain in Sh36 was as follows: r = 0.76 (vs. pain, p < 0.01); r = 0.73

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Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.
Yamashita H, Demizu Y, Shoda T, Sato Y, Oba M, Tanaka M, Kurihara M. Yamashita H, et al. Among authors: tanaka m. Bioorg Med Chem. 2014 Apr 15;22(8):2403-8. doi: 10.1016/j.bmc.2014.03.005. Epub 2014 Mar 13. Bioorg Med Chem. 2014. PMID: 24661993
We synthesized four types of arginine-based amphipathic nonapeptides, including two homochiral peptides, R-(L-Arg-L-Arg-Aib)3-NH2 (R=6-FAM-beta-Ala: FAM-1; R=Ac: Ac-1) and R-(D-Arg-D-Arg-Aib)3-NH2 (R=6-FAM-beta-Ala: ent-FAM-1; R=Ac: ent-A …
We synthesized four types of arginine-based amphipathic nonapeptides, including two homochiral peptides, R-(L-Arg-L-Arg-Aib)3-NH2 ( …
Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury.
Fukumoto Y, Tanaka KF, Parajuli B, Shibata K, Yoshioka H, Kanemaru K, Gachet C, Ikenaka K, Koizumi S, Kinouchi H. Fukumoto Y, et al. Among authors: tanaka kf. J Cereb Blood Flow Metab. 2019 Nov;39(11):2144-2156. doi: 10.1177/0271678X18805317. Epub 2018 Oct 18. J Cereb Blood Flow Metab. 2019. PMID: 30334687 Free PMC article.
Cerebral ischemia resulted in increased microglial P2Y(1)R expression. The number of injured hippocampal neurons was significantly higher in P2Y(1) R knockout (KO) mice than wildtype mice after forebrain ischemia. ...Furthermore, increased PI uptake following OGD wa …
Cerebral ischemia resulted in increased microglial P2Y(1)R expression. The number of injured hippocampal neurons was significantly hi …
Production of R- and S-1,2-propanediol in engineered Lactococcus lactis.
Sato R, Ikeda M, Tanaka T, Ohara H, Aso Y. Sato R, et al. Among authors: tanaka t. AMB Express. 2021 Aug 16;11(1):117. doi: 10.1186/s13568-021-01276-8. AMB Express. 2021. PMID: 34398341 Free PMC article.
These engineered L. lactis produced S- and R-1,2-PDO at concentrations of 0.69 and 0.50 g/L with 94.4 and 78.0% ee optical purities, respectively, from 1% glucose after 72 h of cultivation. ...To our knowledge, this is the first report on the production of R- and S- …
These engineered L. lactis produced S- and R-1,2-PDO at concentrations of 0.69 and 0.50 g/L with 94.4 and 78.0% ee optical purities, …
(S)-Equol Is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency-Induced Bone Loss in Mice.
Tanaka M, Fujii S, Inoue H, Takahashi N, Ishimi Y, Uehara M. Tanaka M, et al. J Nutr. 2022 Aug 9;152(8):1831-1842. doi: 10.1093/jn/nxac130. J Nutr. 2022. PMID: 35675296 Free article.

RESULTS: (S)-equol and (R)-equol inhibited osteoclast differentiation in BMCs (97% and 60%, P < 0.05) and RAW 264.7 cells (83% and 68%, P < 0.05). ...In OVX mice, BMD was ameliorated in (S)-equol-treated mice (11%, P < 0.05), but not in (R)-equol-treated mi

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RESULTS: (S)-equol and (R)-equol inhibited osteoclast differentiation in BMCs (97% and 60%, P < 0.05) and RAW 264.7 cells (83% and

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4,802 results