R01 AI134847/AI/NIAID NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2019	3
2020	1
2021	3
2022	1
2023	5
2024	3

1

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis.

Harrison GA, Wang ER, Cho K, Mreyoud Y, Sarkar S, Almqvist F, Patti GJ, Stallings CL. Harrison GA, et al. mBio. 2024 Mar 13;15(3):e0296823. doi: 10.1128/mbio.02968-23. Epub 2024 Jan 31. mBio. 2024. PMID: 38294237 Free PMC article.

2

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection.

Zou Z, Obernuefemann CLP, Singh P, Pinkner JS, Xu W, Nye TM, Dodson KW, Almqvist F, Hultgren SJ, Caparon MG. Zou Z, et al. bioRxiv [Preprint]. 2024 Jan 3:2024.01.02.573960. doi: 10.1101/2024.01.02.573960. bioRxiv. 2024. PMID: 38260261 Free PMC article. Preprint.

3

Synthesis of Three-Dimensional Ring Fused Heterocycles by a Selective [4 + 2] Cycloaddition Between Bicyclic Thiazolo 2-Pyridones and Arynes.

Sarkar S, Singh P, Edin S, Wendt OF, Almqvist F. Sarkar S, et al. J Org Chem. 2024 Jan 5;89(1):731-739. doi: 10.1021/acs.joc.3c01957. Epub 2023 Dec 14. J Org Chem. 2024. PMID: 38093677 Free PMC article.

4

Design, Synthesis, and Evaluation of Novel Δ²-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant.

Sarkar S, Mayer Bridwell AE, Good JAD, Wang ER, McKee SR, Valenta J, Harrison GA, Flentie KN, Henry FL, Wixe T, Demirel P, Vagolu SK, Chatagnon J, Machelart A, Brodin P, Tønjum T, Stallings CL, Almqvist F. Sarkar S, et al. J Med Chem. 2023 Aug 24;66(16):11056-11077. doi: 10.1021/acs.jmedchem.3c00358. Epub 2023 Jul 24. J Med Chem. 2023. PMID: 37485869 Free PMC article.

5

A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes.

Tükenmez H, Singh P, Sarkar S, Çakır M, Oliveira AH, Lindgren C, Vaitkevicius K, Bonde M, Sauer-Eriksson AE, Almqvist F, Johansson J. Tükenmez H, et al. mBio. 2023 Jun 27;14(3):e0044923. doi: 10.1128/mbio.00449-23. Epub 2023 Apr 25. mBio. 2023. PMID: 37120759 Free PMC article.

6

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis.

Harrison GA, Cho K, Wang ER, Sarkar S, Almqvist F, Patti GJ, Stallings CL. Harrison GA, et al. bioRxiv [Preprint]. 2023 Feb 7:2023.02.06.527416. doi: 10.1101/2023.02.06.527416. bioRxiv. 2023. PMID: 36798348 Free PMC article. Updated. Preprint.

7

Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance.

Samuels AN, Wang ER, Harrison GA, Valenta JC, Stallings CL. Samuels AN, et al. Front Cell Infect Microbiol. 2022 Aug 22;12:958555. doi: 10.3389/fcimb.2022.958555. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36072222 Free PMC article. Review.

8

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones.

Tyagi M, Adolfsson DE, Singh P, Ådén J, Jayaweera SW, Gharibyan A, Bharate JB, Kiss A, Sarkar S, Olofsson A, Almqvist F. Tyagi M, et al. J Org Chem. 2021 Dec 3;86(23):16582-16592. doi: 10.1021/acs.joc.1c01875. Epub 2021 Nov 12. J Org Chem. 2021. PMID: 34767366 Free PMC article.

9

A 2-pyridone amide inhibitor of transcriptional activity in Chlamydia trachomatis.

Núñez-Otero C, Bahnan W, Vielfort K, Silver J, Singh P, Elbir H, Almqvist F, Bergström S, Gylfe Å. Núñez-Otero C, et al. Antimicrob Agents Chemother. 2023 May 1;95(5):e01826-20. doi: 10.1128/AAC.01826-20. Epub 2021 Feb 16. Antimicrob Agents Chemother. 2023. PMID: 33593835 Free PMC article.

10

Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c.

Tükenmez H, Sarkar S, Anoosheh S, Kruchanova A, Edström I, Harrison GA, Stallings CL, Almqvist F, Larsson C. Tükenmez H, et al. Sci Rep. 2021 Jan 15;11(1):1523. doi: 10.1038/s41598-021-81104-y. Sci Rep. 2021. PMID: 33452380 Free PMC article.

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