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A signal transducer and activator of transcription 3·Nuclear Factor κB (Stat3·NFκB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-α.
J Biol Chem. 2014 Oct 24;289(43):30082-9. doi: 10.1074/jbc.M114.591719. Epub 2014 Sep 11.
J Biol Chem. 2014.
PMID: 25213863
Free PMC article.
Molecular mechanism of fascin function in filopodial formation.
Yang S, Huang FK, Huang J, Chen S, Jakoncic J, Leo-Macias A, Diaz-Avalos R, Chen L, Zhang JJ, Huang XY.
Yang S, et al.
J Biol Chem. 2013 Jan 4;288(1):274-84. doi: 10.1074/jbc.M112.427971. Epub 2012 Nov 26.
J Biol Chem. 2013.
PMID: 23184945
Free PMC article.
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Mouse models for tumor metastasis.
Yang S, Zhang JJ, Huang XY.
Yang S, et al.
Methods Mol Biol. 2012;928:221-8. doi: 10.1007/978-1-62703-008-3_17.
Methods Mol Biol. 2012.
PMID: 22956145
Free PMC article.
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Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration.
Snyder M, Huang XY, Zhang JJ.
Snyder M, et al.
J Biol Chem. 2011 Nov 11;286(45):38886-93. doi: 10.1074/jbc.M111.286245. Epub 2011 Sep 20.
J Biol Chem. 2011.
PMID: 21937440
Free PMC article.
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Migrastatin analogues target fascin to block tumour metastasis.
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY.
Chen L, et al.
Nature. 2010 Apr 15;464(7291):1062-6. doi: 10.1038/nature08978.
Nature. 2010.
PMID: 20393565
Free PMC article.
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