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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.
Vital T, Wali A, Butler KV, Xiong Y, Foster JP 2nd, Marcel SS, McFadden AW, Nguyen VU, Bailey BM, Lamb KN, James LI, Frye SV, Mosely AL, Jin J, Pattenden SG, Davis IJ. Vital T, et al. Front Oncol. 2023 Jan 30;13:1099550. doi: 10.3389/fonc.2023.1099550. eCollection 2023. Front Oncol. 2023. PMID: 36793594 Free PMC article.
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.
Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, DiFiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BD, Rathmell WK. Hacker KE, et al. J Biol Chem. 2016 Sep 30;291(40):21283-21295. doi: 10.1074/jbc.M116.739375. Epub 2016 Aug 15. J Biol Chem. 2016. PMID: 27528607 Free PMC article.
27 results