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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
Multiple domain interfaces mediate SARM1 autoinhibition.
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Shen C, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2023151118. doi: 10.1073/pnas.2023151118. Proc Natl Acad Sci U S A. 2021. PMID: 33468661 Free PMC article.
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