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Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease.
Ngo C, Fried W, Aliyari S, Feng J, Qin C, Zhang S, Yang H, Shanaa J, Feng P, Cheng G, Chen XS, Zhang C. Ngo C, et al. J Med Chem. 2023 Sep 14;66(17):12237-12248. doi: 10.1021/acs.jmedchem.3c00810. Epub 2023 Aug 18. J Med Chem. 2023. PMID: 37595260 Free PMC article.
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.
Dong W, Wang J, Tian L, Zhang J, Settles EW, Qin C, Steinken-Kollath DR, Itogawa AN, Celona KR, Yi J, Bryant M, Mead H, Jaramillo SA, Lu H, Li A, Zumwalt RE, Dadwal S, Feng P, Yuan W, Whelan SPJ, Keim PS, Barker BM, Caligiuri MA, Yu J. Dong W, et al. Nat Commun. 2023 Apr 6;14(1):1936. doi: 10.1038/s41467-023-37336-9. Nat Commun. 2023. PMID: 37024459 Free PMC article.
STeerING PI4P for innate immune activation.
Qin C, Feng S, Feng P. Qin C, et al. Immunity. 2023 Mar 14;56(3):463-465. doi: 10.1016/j.immuni.2023.02.012. Immunity. 2023. PMID: 36921569
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis.
Qin C, Rao Y, Yuan H, Wang TY, Zhao J, Espinosa B, Liu Y, Zhang S, Savas AC, Liu Q, Zarinfar M, Rice S, Henley J, Comai L, Graham NA, Chen C, Zhang C, Feng P. Qin C, et al. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2122897119. doi: 10.1073/pnas.2122897119. Epub 2022 Jun 14. Proc Natl Acad Sci U S A. 2022. PMID: 35700355 Free PMC article.
25 results