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Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.
Ikin AF, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashiyama S, Mustelin T, Burgoyne RD, Gandy S. Ikin AF, et al. Mol Neurodegener. 2007 Dec 9;2:23. doi: 10.1186/1750-1326-2-23. Mol Neurodegener. 2007. PMID: 18067682 Free PMC article.
Breaking up (amyloid) is hard to do.
Gandy S, Heppner FL. Gandy S, et al. PLoS Med. 2005 Dec;2(12):e417. doi: 10.1371/journal.pmed.0020417. Epub 2005 Dec 27. PLoS Med. 2005. PMID: 16363913 Free PMC article.