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Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward.
Abraham AD, Casello SM, Land BB, Chavkin C. Abraham AD, et al. Addict Neurosci. 2022 Mar;1:100005. doi: 10.1016/j.addicn.2022.100005. Epub 2022 Jan 25. Addict Neurosci. 2022. PMID: 36176476 Free PMC article.
Will biased ligands be the opioids of the future?
Ballantyne JC, Chavkin C. Ballantyne JC, et al. Pain. 2020 Sep 1;161(9):1945-1948. doi: 10.1097/j.pain.0000000000001913. Pain. 2020. PMID: 32379220 No abstract available.
Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.
Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C. Schattauer SS, et al. J Biol Chem. 2019 Nov 8;294(45):16884-16896. doi: 10.1074/jbc.RA119.009592. Epub 2019 Oct 1. J Biol Chem. 2019. PMID: 31575661 Free PMC article.
22 results