The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics.
Sherman DJ, Liu L, Mamrosh JL, Xie J, Ferbas J, Lomenick B, Ladinsky MS, Verma R, Rulifson IC, Deshaies RJ.
Sherman DJ, et al.
Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2318619121. doi: 10.1073/pnas.2318619121. Epub 2024 Apr 24.
Proc Natl Acad Sci U S A. 2024.
PMID: 38657050
To identify their intracellular associations, we generated a paired set of isogenic human hepatoma cells expressing PNPLA3 and PNPLA3-I148M at endogenous levels. ...Cumulatively, we validate an endogenous human cellular system for investigating PNPLA3-I148M biology …
To identify their intracellular associations, we generated a paired set of isogenic human hepatoma cells expressing PNPLA3 and PNPLA3 …