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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. Zhang X, et al. Nat Commun. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109. Nat Commun. 2016. PMID: 27357649 Free PMC article.
Lysosomal physiology.
Xu H, Ren D. Xu H, et al. Annu Rev Physiol. 2015;77:57-80. doi: 10.1146/annurev-physiol-021014-071649. Annu Rev Physiol. 2015. PMID: 25668017 Free PMC article. Review.
Lysosomal exocytosis and lipid storage disorders.
Samie MA, Xu H. Samie MA, et al. J Lipid Res. 2014 Jun;55(6):995-1009. doi: 10.1194/jlr.R046896. Epub 2014 Mar 25. J Lipid Res. 2014. PMID: 24668941 Free PMC article. Review.
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.
Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, Gregg E, Azar M, Zhuo Y, Garrity AG, Gao Q, Slaugenhaupt S, Pickel J, Zolov SN, Weisman LS, Lenk GM, Titus S, Bryant-Genevier M, Southall N, Juan M, Ferrer M, Xu H. Samie M, et al. Dev Cell. 2013 Sep 16;26(5):511-24. doi: 10.1016/j.devcel.2013.08.003. Epub 2013 Aug 29. Dev Cell. 2013. PMID: 23993788 Free PMC article.