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Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts.
Krisanits BA, Woods P, Nogueira LM, Woolfork DD, Lloyd CE, Baldwin A, Frye CC, Peterson KD, Cosh SD, Guo QJ, Spruill LS, Lilly MB, Helke K, Li H, Hanna GS, Hamann MT, Thomas C, Ahmed M, Gooz MB, Findlay VJ, Turner DP. Krisanits BA, et al. Transl Oncol. 2022 Mar;17:101350. doi: 10.1016/j.tranon.2022.101350. Epub 2022 Jan 25. Transl Oncol. 2022. PMID: 35091340 Free PMC article.
Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention.
Walter KR, Ford ME, Gregoski MJ, Kramer RM, Knight KD, Spruill L, Nogueira LM, Krisanits BA, Phan V, La Rue AC, Lilly MB, Ambs S, Chan K, Turner TF, Varner H, Singh S, Uribarri J, Garrett-Mayer E, Armeson KE, Hilton EJ, Clair MJ, Taylor MH, Abbott AM, Findlay VJ, Peterson LL, Magwood G, Turner DP. Walter KR, et al. Breast Cancer Res Treat. 2019 Feb;173(3):559-571. doi: 10.1007/s10549-018-4992-7. Epub 2018 Oct 27. Breast Cancer Res Treat. 2019. PMID: 30368741 Free PMC article.
AGE metabolites: a biomarker linked to cancer disparity?
Foster D, Spruill L, Walter KR, Nogueira LM, Fedarovich H, Turner RY, Ahmed M, Salley JD, Ford ME, Findlay VJ, Turner DP. Foster D, et al. Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2186-91. doi: 10.1158/1055-9965.EPI-14-0564. Epub 2014 Jul 22. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 25053712 Free PMC article.