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Structure and function of the histone chaperone FACT - Resolving FACTual issues.
Gurova K, Chang HW, Valieva ME, Sandlesh P, Studitsky VM. Gurova K, et al. Biochim Biophys Acta Gene Regul Mech. 2018 Jul 25:S1874-9399(18)30159-7. doi: 10.1016/j.bbagrm.2018.07.008. Online ahead of print. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 30055319 Free PMC article. Review.
FACT is a sensor of DNA torsional stress in eukaryotic cells.
Safina A, Cheney P, Pal M, Brodsky L, Ivanov A, Kirsanov K, Lesovaya E, Naberezhnov D, Nesher E, Koman I, Wang D, Wang J, Yakubovskaya M, Winkler D, Gurova K. Safina A, et al. Nucleic Acids Res. 2017 Feb 28;45(4):1925-1945. doi: 10.1093/nar/gkw1366. Nucleic Acids Res. 2017. PMID: 28082391 Free PMC article.
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.
Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford AJ, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, Ling D, Kim PY, Webber H, Clark A, Ruhle M, Liu B, Oberthuer A, Fischer M, Byrne J, Saletta F, Thwe le M, Purmal A, Haderski G, Burkhart C, Speleman F, De Preter K, Beckers A, Ziegler DS, Liu T, Gurova KV, Gudkov AV, Norris MD, Haber M, Marshall GM. Carter DR, et al. Sci Transl Med. 2015 Nov 4;7(312):312ra176. doi: 10.1126/scitranslmed.aab1803. Sci Transl Med. 2015. PMID: 26537256 Free PMC article.