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Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.
Knebel UE, Peleg S, Dai C, Cohen-Fultheim R, Jonsson S, Poznyak K, Israeli M, Zamashanski L, Glaser B, Levanon EY, Powers AC, Klochendler A, Dor Y. Knebel UE, et al. Cell Metab. 2024 Jan 2;36(1):48-61.e6. doi: 10.1016/j.cmet.2023.11.011. Epub 2023 Dec 20. Cell Metab. 2024. PMID: 38128529 Free article.
Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2.
Spears E, Stanley JE, Shou M, Yin L, Li X, Dai C, Bradley A, Sellick K, Poffenberger G, Coate KC, Shrestha S, Jenkins R, Sloop KW, Wilson KT, Attie AD, Keller MP, Chen W, Powers AC, Dean ED. Spears E, et al. bioRxiv [Preprint]. 2023 Aug 14:2023.08.10.552656. doi: 10.1101/2023.08.10.552656. bioRxiv. 2023. PMID: 37645716 Free PMC article. Preprint.
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.
Richardson TM, Saunders DC, Haliyur R, Shrestha S, Cartailler JP, Reinert RB, Petronglo J, Bottino R, Aramandla R, Bradley AM, Jenkins R, Phillips S, Kang H; Human Pancreas Analysis Program; Caicedo A, Powers AC, Brissova M. Richardson TM, et al. Am J Physiol Endocrinol Metab. 2023 Mar 1;324(3):E251-E267. doi: 10.1152/ajpendo.00246.2022. Epub 2023 Jan 25. Am J Physiol Endocrinol Metab. 2023. PMID: 36696598 Free PMC article.
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M. Anderson AM, et al. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2107208118. doi: 10.1073/pnas.2107208118. Proc Natl Acad Sci U S A. 2021. PMID: 34611019 Free PMC article.
The Human Islet: Mini-Organ With Mega-Impact.
Walker JT, Saunders DC, Brissova M, Powers AC. Walker JT, et al. Endocr Rev. 2021 Sep 28;42(5):605-657. doi: 10.1210/endrev/bnab010. Endocr Rev. 2021. PMID: 33844836 Free PMC article. Review.
50 results