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Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.
Boeynaems S, Dorone Y, Zhuang Y, Shabardina V, Huang G, Marian A, Kim G, Sanyal A, Şen NE, Griffith D, Docampo R, Lasker K, Ruiz-Trillo I, Auburger G, Holehouse AS, Kabashi E, Lin Y, Gitler AD. Boeynaems S, et al. Mol Cell. 2023 Jun 15;83(12):2020-2034.e6. doi: 10.1016/j.molcel.2023.05.025. Epub 2023 Jun 8. Mol Cell. 2023. PMID: 37295429
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease.
Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Haver DV, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. Boeynaems S, et al. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531820. doi: 10.1101/2023.03.09.531820. bioRxiv. 2023. PMID: 36945394 Free PMC article. Preprint.
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.
Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD. Rodriguez CM, et al. Cell Rep. 2022 Oct 25;41(4):111505. doi: 10.1016/j.celrep.2022.111505. Cell Rep. 2022. PMID: 36288715 Free PMC article.
28 results