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Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative.
J Med Chem. 2021 Feb 25;64(4):1856-1872. doi: 10.1021/acs.jmedchem.0c01886. Epub 2021 Feb 7.
J Med Chem. 2021.
PMID: 33550801
Free PMC article.
Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption.
Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD.
Napimoga MH, et al.
J Periodontal Res. 2018 Oct;53(5):743-749. doi: 10.1111/jre.12559. Epub 2018 May 31.
J Periodontal Res. 2018.
PMID: 29851077
Free PMC article.
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Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases.
Wagner KM, McReynolds CB, Schmidt WK, Hammock BD.
Wagner KM, et al.
Pharmacol Ther. 2017 Dec;180:62-76. doi: 10.1016/j.pharmthera.2017.06.006. Epub 2017 Jun 19.
Pharmacol Ther. 2017.
PMID: 28642117
Free PMC article.
Review.
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Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis.
Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD.
Trindade-da-Silva CA, et al.
J Pharmacol Exp Ther. 2017 Jun;361(3):408-416. doi: 10.1124/jpet.116.238113. Epub 2017 Mar 29.
J Pharmacol Exp Ther. 2017.
PMID: 28356494
Free PMC article.
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Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.
Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD.
Inceoglu B, et al.
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. doi: 10.1073/pnas.1510137112. Epub 2015 Jul 6.
Proc Natl Acad Sci U S A. 2015.
PMID: 26150506
Free PMC article.
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