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Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595.
Eidson LN, deSousa Rodrigues ME, Johnson MA, Barnum CJ, Duke BJ, Yang Y, Chang J, Kelly SD, Wildner M, Tesi RJ, Tansey MG. Eidson LN, et al. Brain Behav Immun. 2019 Oct;81:305-316. doi: 10.1016/j.bbi.2019.06.027. Epub 2019 Jun 25. Brain Behav Immun. 2019. PMID: 31251975 Free PMC article.
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.
de Sousa Rodrigues ME, Bekhbat M, Houser MC, Chang J, Walker DI, Jones DP, Oller do Nascimento CMP, Barnum CJ, Tansey MG. de Sousa Rodrigues ME, et al. Brain Behav Immun. 2017 Jan;59:158-172. doi: 10.1016/j.bbi.2016.08.021. Epub 2016 Sep 2. Brain Behav Immun. 2017. PMID: 27592562 Free PMC article.