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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 6
1992 6
1993 11
1994 9
1995 9
1996 14
1997 10
1998 15
1999 12
2000 14
2001 16
2002 18
2003 16
2004 8
2005 15
2006 18
2007 21
2008 13
2009 11
2010 15
2011 23
2012 24
2013 20
2014 30
2015 23
2016 36
2017 45
2018 37
2019 23
2020 25
2021 40
2022 33
2023 36
2024 21

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608 results

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Page 1
Nociceptor neurons affect cancer immunosurveillance.
Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, Roversi K, Lucido CT, Restaino AC, Huang S, Ji L, Huang KC, Semerena E, Thomas SC, Trevino AE, Merrison H, Parrin A, Doyle B, Vermeer DW, Spanos WC, Williamson CS, Seehus CR, Foster SL, Dai H, Shu CJ, Rangachari M, Thibodeau J, V Del Rincon S, Drapkin R, Rafei M, Ghasemlou N, Vermeer PD, Woolf CJ, Talbot S. Balood M, et al. Nature. 2022 Nov;611(7935):405-412. doi: 10.1038/s41586-022-05374-w. Epub 2022 Nov 2. Nature. 2022. PMID: 36323780 Free PMC article.
Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unclear. Here we show that melanoma cells interact with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness to noxious ligand …
Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unclear. Here we …
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer.
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R. Salazar Y, et al. J Clin Invest. 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037. J Clin Invest. 2020. PMID: 32229721 Free PMC article.
Immune microenvironment plays a critical role in lung cancer control versus progression and metastasis. In this investigation, we explored the effect of tumor-infiltrating lymphocyte subpopulations on lung cancer biology by studying in vitro cocultures, in vivo mous …
Immune microenvironment plays a critical role in lung cancer control versus progression and metastasis. In this investigation, we exp …
IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts.
Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M. Picard FSR, et al. Gut. 2023 Aug;72(8):1510-1522. doi: 10.1136/gutjnl-2022-327855. Epub 2023 Feb 9. Gut. 2023. PMID: 36759154 Free PMC article.
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and interspersed immune cells. ...Wild-type (WT) or Il17ra(-/-) quiescent pancreatic stellate cells (qPSC) were exposed to …
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated …
Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response.
Sethi V, Kurtom S, Tarique M, Lavania S, Malchiodi Z, Hellmund L, Zhang L, Sharma U, Giri B, Garg B, Ferrantella A, Vickers SM, Banerjee S, Dawra R, Roy S, Ramakrishnan S, Saluja A, Dudeja V. Sethi V, et al. Gastroenterology. 2018 Jul;155(1):33-37.e6. doi: 10.1053/j.gastro.2018.04.001. Epub 2018 Apr 7. Gastroenterology. 2018. PMID: 29630898 Free PMC article.
We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. …
We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancre …
Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model.
Wang S, Wu Q, Chen T, Su R, Pan C, Qian J, Huang H, Yin S, Xie H, Zhou L, Zheng S. Wang S, et al. J Hepatol. 2022 Aug;77(2):467-478. doi: 10.1016/j.jhep.2022.03.011. Epub 2022 Apr 1. J Hepatol. 2022. PMID: 35367532
An orthotopic liver tumour model was used to evaluate the function of the CD103(+) DC-NK cell axis after CD47 blockade in vivo in wild-type, Rag1(-/-), Batf3(-/-), and STING1(-/-) mice. Phagocytosis assays were performed in CD103(+) DC and HCC cell lines. ...CONCLUSIONS: I …
An orthotopic liver tumour model was used to evaluate the function of the CD103(+) DC-NK cell axis after CD47 blockade in vivo in wild-type, …
Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells.
Kang T, Ge M, Wang R, Tan Z, Zhang X, Zhu C, Liu H, Chen S. Kang T, et al. J Exp Clin Cancer Res. 2019 Dec 10;38(1):487. doi: 10.1186/s13046-019-1471-x. J Exp Clin Cancer Res. 2019. PMID: 31822296 Free PMC article.
The expression of recombination activating gene 1 (RAG1) in gastric cancer cell lines was determined by RNA-sequencing analyses and Real-Time qPCR. ...We show that NFATc3 targets the promoter of RAG1 for transcriptional inhibition. We further showed that NFAT …
The expression of recombination activating gene 1 (RAG1) in gastric cancer cell lines was determined by RNA-sequencing analyse …
NAD metabolism fuels human and mouse intestinal inflammation.
Gerner RR, Klepsch V, Macheiner S, Arnhard K, Adolph TE, Grander C, Wieser V, Pfister A, Moser P, Hermann-Kleiter N, Baier G, Oberacher H, Tilg H, Moschen AR. Gerner RR, et al. Gut. 2018 Oct;67(10):1813-1823. doi: 10.1136/gutjnl-2017-314241. Epub 2017 Sep 6. Gut. 2018. PMID: 28877980 Free PMC article.
DESIGN: We investigated the impact of NAMPT inhibition by the small-molecule inhibitor FK866 in the dextran sulfate sodium (DSS) model of colitis and the azoxymethane/DSS model of colitis-associated cancer. The impact of NAD depletion on differentiation of mouse and human …
DESIGN: We investigated the impact of NAMPT inhibition by the small-molecule inhibitor FK866 in the dextran sulfate sodium (DSS) model of co …
AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway.
Pokhrel RH, Acharya S, Ahn JH, Gu Y, Pandit M, Kim JO, Park YY, Kang B, Ko HJ, Chang JH. Pokhrel RH, et al. Mol Cancer. 2021 Oct 14;20(1):133. doi: 10.1186/s12943-021-01420-9. Mol Cancer. 2021. PMID: 34649584 Free PMC article.
BACKGROUND: AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, particularly the function of regulatory T cells (Tregs), …
BACKGROUND: AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppresso …
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ. Britton GJ, et al. Immunity. 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. Immunity. 2019. PMID: 30650377 Free PMC article.
Colonization with IBD microbiotas exacerbated disease in a model where colitis is induced upon transfer of naive T cells into Rag1(-/-) mice. The proportions of Th17 and RORgammat(+) Treg cells induced by each microbiota were predictive of human disease status and accounte …
Colonization with IBD microbiotas exacerbated disease in a model where colitis is induced upon transfer of naive T cells into Rag1(-/ …
Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells.
Chen TY, Yang CY, Yang MT, Kuo TF, Chang CL, Chen CL, Lee TH, Yang G, Yang WC, Chiu CF, Yu AY. Chen TY, et al. Clin Transl Med. 2022 Feb;12(2):e606. doi: 10.1002/ctm2.606. Clin Transl Med. 2022. PMID: 35170261 Free PMC article.
Genetics studies in tumour-bearing wild-type and Pdia4(-/-) mice showed that host Pdia4 promoted lung cancer development in the mice via cancer stroma. This promotion was abolished in Rag1(-/-) mice which lacked T and B cells. ...CONCLUSIONS: These findings i …
Genetics studies in tumour-bearing wild-type and Pdia4(-/-) mice showed that host Pdia4 promoted lung cancer development in the mice …
608 results