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Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial.
Dunning J, Sahr F, Rojek A, Gannon F, Carson G, Idriss B, Massaquoi T, Gandi R, Joseph S, Osman HK, Brooks TJ, Simpson AJ, Goodfellow I, Thorne L, Arias A, Merson L, Castle L, Howell-Jones R, Pardinaz-Solis R, Hope-Gill B, Ferri M, Grove J, Kowalski M, Stepniewska K, Lang T, Whitehead J, Olliaro P, Samai M, Horby PW; RAPIDE-TKM trial team. Dunning J, et al. PLoS Med. 2016 Apr 19;13(4):e1001997. doi: 10.1371/journal.pmed.1001997. eCollection 2016 Apr. PLoS Med. 2016. PMID: 27093560 Free PMC article. Clinical Trial.
Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease:  plasma concentrations exceed target levels, with drug accumulation in the most severe patients.
Scott JT, Sharma R, Meredith LW, Dunning J, Moore CE, Sahr F, Ward S, Goodfellow I, Horby P; RAPIDE-TKM trial team. Scott JT, et al. EBioMedicine. 2020 Feb;52:102601. doi: 10.1016/j.ebiom.2019.102601. Epub 2020 Jan 14. EBioMedicine. 2020. PMID: 31953031 Free PMC article.