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RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing.
Yan Q, Zeng P, Zhou X, Zhao X, Chen R, Qiao J, Feng L, Zhu Z, Zhang G, Chen C. Yan Q, et al. Oncogene. 2021 Apr;40(15):2635-2650. doi: 10.1038/s41388-021-01666-z. Epub 2021 Feb 9. Oncogene. 2021. PMID: 33564070 Free PMC article.
However, the role of RBMX in BCa tumorigenicity and progression remains unclear. In this study, we found that RBMX was significantly downregulated in BCa tissues, especially in muscle-invasive BCa tissues. ...RBMX may serve as a novel prognostic biomarker for …
However, the role of RBMX in BCa tumorigenicity and progression remains unclear. In this study, we found that RBMX was signifi …
Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response.
Sheng Y, Lei K, Sun C, Liu J, Tu Z, Zhu X, Huang K. Sheng Y, et al. Aging (Albany NY). 2024 Jan 11;16(1):226-245. doi: 10.18632/aging.205363. Epub 2024 Jan 11. Aging (Albany NY). 2024. PMID: 38214653 Free PMC article.
The results showed that knockdown of RBMX can impair the proliferation, migration, and invasion of liver cancer cells. Finally, we indicated that RBMX may play an immunoregulatory role in cancer progression, affecting the therapeutic effects of immune …
The results showed that knockdown of RBMX can impair the proliferation, migration, and invasion of liver cancer cells. Finally …
Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.
Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, Gourkanti S, Chou T, Barin E, Velleca A, Rohwetter T, Chow A, Taggart J, Savino AM, Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C, Steidl U, Rabadan R, Kharas MG. Prieto C, et al. Nat Cancer. 2021 Jul;2:741-757. doi: 10.1038/s43018-021-00220-w. Epub 2021 Jul 5. Nat Cancer. 2021. PMID: 34458856 Free PMC article.
RBMX/L1 are overexpressed in acute myeloid leukemia (AML) primary patients compared to healthy individuals, and RBMX/L1 loss delayed leukemia development. ...Forced CBX5 expression rescued the RBMX/L1 depletion effects on cell growth and apoptosis. Overall, w …
RBMX/L1 are overexpressed in acute myeloid leukemia (AML) primary patients compared to healthy individuals, and RBMX/L1 loss d …
RBMX family proteins connect the fields of nuclear RNA processing, disease and sex chromosome biology.
Elliott DJ, Dalgliesh C, Hysenaj G, Ehrmann I. Elliott DJ, et al. Int J Biochem Cell Biol. 2019 Mar;108:1-6. doi: 10.1016/j.biocel.2018.12.014. Epub 2018 Dec 26. Int J Biochem Cell Biol. 2019. PMID: 30593955 Review.
RBMX is a ubiquitously expressed nuclear RNA binding protein that is encoded by a gene on the X chromosome. ...These RNA binding proteins are important for normal development, and also implicated in cancer and viral infection. At the molecular level RBMX fami …
RBMX is a ubiquitously expressed nuclear RNA binding protein that is encoded by a gene on the X chromosome. ...These RNA binding prot …
m6A reading protein RBMX as a biomarker for prognosis and tumor progression in esophageal cancer.
Tuersun H, Liu L, Zhang J, Maimaitizunong R, Tang X, Li H. Tuersun H, et al. Transl Cancer Res. 2023 Sep 30;12(9):2319-2335. doi: 10.21037/tcr-23-84. Epub 2023 Aug 30. Transl Cancer Res. 2023. PMID: 37859733 Free PMC article.
However, the prognostic significance of RBMX expression in esophageal cancer (ESCA) remains unclear. METHODS: Based on the TIMER database, GEPIA database, cBioPortal database, CIBERSORT deconvolution algorithm, String-DB database, LinkedOmics database, etc., the …
However, the prognostic significance of RBMX expression in esophageal cancer (ESCA) remains unclear. METHODS: Based on the TIM …
RBMX involves in telomere stability maintenance by regulating TERRA expression.
Liu J, Zheng T, Chen D, Huang J, Zhao Y, Ma W, Liu H. Liu J, et al. PLoS Genet. 2023 Sep 27;19(9):e1010937. doi: 10.1371/journal.pgen.1010937. eCollection 2023 Sep. PLoS Genet. 2023. PMID: 37756323 Free PMC article.
We also found that RBMX binds to TERRA and the nuclear exosome targeting protein ZCCHC8 simultaneously, and that TERRA degradation slows down upon RBMX depletion, implying that RBMX promotes TERRA degradation by regulating its transportation to the nuclear ex …
We also found that RBMX binds to TERRA and the nuclear exosome targeting protein ZCCHC8 simultaneously, and that TERRA degradation sl …
Comprehensive analysis of m6A related gene mutation characteristics and prognosis in colorectal cancer.
Jiang T, Xing L, Zhao L, Ye Z, Yu D, Lin S. Jiang T, et al. BMC Med Genomics. 2023 May 16;16(1):105. doi: 10.1186/s12920-023-01509-8. BMC Med Genomics. 2023. PMID: 37194014 Free PMC article.
BACKGROUND: Colorectal cancer is considered as the second most common cancer worldwide. Studies have shown that m6A RNA methylation abnormalities play an important role in the pathogenesis of many human diseases, including cancer. ...CONCLUSION: Our study ide …
BACKGROUND: Colorectal cancer is considered as the second most common cancer worldwide. Studies have shown that m6A RNA methyl …
Underexpression of SRSF3 and its target gene RBMX predicts good prognosis in patients with head and neck cancer.
Guo J, Wang X, Jia J, Jia R. Guo J, et al. J Oral Sci. 2020 Mar 28;62(2):175-179. doi: 10.2334/josnusd.18-0485. Epub 2020 Mar 4. J Oral Sci. 2020. PMID: 32132325 Free article.
Head and neck cancer collectively is one of the most common cancer types in the world. ...These results suggest that the underexpression of SRSF3 and that of its target RBMX can be used as potential biomarkers to predict favorable overall survival among head …
Head and neck cancer collectively is one of the most common cancer types in the world. ...These results suggest that the under …
[RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2].
Yan Q, Zeng P, Huang S, Tan C, Zhou X, Qiao J, Zhao X, Feng L, Zhu Z, Zhang G, Hu H, Chen C. Yan Q, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Jan 20;44(1):9-16. doi: 10.12122/j.issn.1673-4254.2024.01.02. Nan Fang Yi Ke Da Xue Xue Bao. 2024. PMID: 38293971 Free PMC article. Chinese.
OBJECTIVE: To investigate the role of RNA-binding motif protein X-linked (RBMX) in regulating the proliferation, migration, invasion and glycolysis in human bladder cancer cells. ...CONCLUSION: RBMX overexpression inhibits bladder cancer progression an …
OBJECTIVE: To investigate the role of RNA-binding motif protein X-linked (RBMX) in regulating the proliferation, migration, invasion …
Identification of clinical prognostic features of esophageal cancer based on m6A regulators.
Wang H, Zhang Y, Chen L, Liu Y, Xu C, Jiang D, Song Q, Wang H, Wang L, Lin Y, Chen Y, Chen J, Xu Y, Hou Y. Wang H, et al. Front Immunol. 2022 Sep 8;13:950365. doi: 10.3389/fimmu.2022.950365. eCollection 2022. Front Immunol. 2022. PMID: 36159855 Free PMC article.
BACKGROUND: Esophageal cancer (ESCA) is a common malignancy with high morbidity and mortality. n6-methyladenosine (m6A) regulators have been widely recognized as one of the major causes of cancer development and progression. ...LASSO regression analysis included 7 m …
BACKGROUND: Esophageal cancer (ESCA) is a common malignancy with high morbidity and mortality. n6-methyladenosine (m6A) regulators ha …
66 results