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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1989 3
1990 1
1994 3
1995 3
1996 2
1997 2
1998 4
1999 2
2000 1
2001 4
2002 2
2003 4
2004 4
2005 3
2006 2
2007 2
2008 7
2009 4
2010 3
2011 3
2012 3
2013 3
2014 3
2015 7
2016 10
2017 6
2018 7
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2020 6
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2022 5
2023 9
2024 4

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133 results

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Page 1
The intricate roles of RCC1 in normal cells and cancer cells.
Jing L, Kwok HF. Jing L, et al. Biochem Soc Trans. 2022 Feb 28;50(1):83-93. doi: 10.1042/BST20210861. Biochem Soc Trans. 2022. PMID: 35191966 Review.
RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog). ...Over the last decade, increasing evidence has emerged highlighting the potential relevance …
RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide e …
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY. Huang T, et al. Mol Cell. 2021 Mar 18;81(6):1276-1291.e9. doi: 10.1016/j.molcel.2021.01.015. Epub 2021 Feb 3. Mol Cell. 2021. PMID: 33539787 Free PMC article.
CK2 phosphorylates and stabilizes PRMT6 through deubiquitylation, which promotes PRMT6 methylation of RCC1, which in turn is required for RCC1 association with chromatin and activation of RAN. ...This study identifies a CK2alpha-PRMT6-RCC1 signaling axis that …
CK2 phosphorylates and stabilizes PRMT6 through deubiquitylation, which promotes PRMT6 methylation of RCC1, which in turn is required …
Novel Ran-RCC1 Inhibitory Peptide-Loaded Nanoparticles Have Anti-Cancer Efficacy In Vitro and In Vivo.
Haggag YA, Matchett KB, Falconer RA, Isreb M, Jones J, Faheem A, McCarron P, El-Tanani M. Haggag YA, et al. Cancers (Basel). 2019 Feb 14;11(2):222. doi: 10.3390/cancers11020222. Cancers (Basel). 2019. PMID: 30769871 Free PMC article.
Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therapeutic target in breast cancer, were delivered by entrapment into polyethylene glycol-poly (lactic-co-glycolic acid) PEG-PLGA polymeri …
Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therap …
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D. Liu Y, et al. J Exp Clin Cancer Res. 2023 Feb 1;42(1):38. doi: 10.1186/s13046-023-02609-0. J Exp Clin Cancer Res. 2023. PMID: 36721234 Free PMC article.
METHODS: RNA-sequencing (RNA-seq) analysis was performed to identify the differential gene expression signature in primary human hepatocytes treated with or without inflammatory stimulus. A giant E3 ubiquitin protein ligase, HECT domain and RCC1-like domain 2 (HERC2), was …
METHODS: RNA-sequencing (RNA-seq) analysis was performed to identify the differential gene expression signature in primary human hepatocytes …
SNORA73B promotes endometrial cancer progression through targeting MIB1 and regulating host gene RCC1 alternative splicing.
Chen X, Li QH, Xie BM, Ji YM, Han Y, Zhao Y. Chen X, et al. J Cell Mol Med. 2023 Oct;27(19):2890-2905. doi: 10.1111/jcmm.17850. Epub 2023 Jul 24. J Cell Mol Med. 2023. PMID: 37488742 Free PMC article.
Endometrial cancer (EC) is a common gynaecological malignant tumour with unclear pathogenesis. Small nucleolar RNA (snoRNA) is involved in many biological processes, including those of cancers. Using the Cancer Genome Atlas (TCGA) database, the expression pat …
Endometrial cancer (EC) is a common gynaecological malignant tumour with unclear pathogenesis. Small nucleolar RNA (snoRNA) is involv …
Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools.
Suszynska M, Ratajska M, Galka-Marciniak P, Ryszkowska A, Wydra D, Debniak J, Jasiak A, Wasag B, Cybulski C, Kozlowski P. Suszynska M, et al. Cancer Prev Res (Phila). 2022 Mar 1;15(3):151-160. doi: 10.1158/1940-6207.CAPR-21-0295. Cancer Prev Res (Phila). 2022. PMID: 34906988
In this study, we aimed to analyze knowledge-based selected genes, that is, BARD1, PRDM9, RCC1, and RECQL, in which pathogenic germline variants have been reported in patients with breast and/or ovarian cancer. As deep sequencing of DNA samples remains costly, targe …
In this study, we aimed to analyze knowledge-based selected genes, that is, BARD1, PRDM9, RCC1, and RECQL, in which pathogenic germli …
RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability.
Wu Y, Xu Z, Chen X, Fu G, Tian J, Jin B. Wu Y, et al. Cancer Med. 2023 Oct;12(19):19889-19903. doi: 10.1002/cam4.6594. Epub 2023 Sep 25. Cancer Med. 2023. PMID: 37747077 Free PMC article.
RCC1 and EZH2 expression showed a strong correlation in clinical samples. ...CONCLUSIONS: RCC1 could be a potential therapeutic target in ccRCC. The RCC1/EZH2 axis takes part in the development of ccRCC....
RCC1 and EZH2 expression showed a strong correlation in clinical samples. ...CONCLUSIONS: RCC1 could be a potential therapeuti …
Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
Hou X, Qiao L, Liu R, Han X, Zhang W. Hou X, et al. Biomolecules. 2021 Jul 6;11(7):995. doi: 10.3390/biom11070995. Biomolecules. 2021. PMID: 34356619 Free PMC article.
Persistent infection of high-risk human papillomavirus (HR-HPV) plays a causal role in cervical cancer. Regulator of chromosome condensation 1 (RCC1) is a critical cell cycle regulator, which undergoes a few post-translational modifications including phosphorylation …
Persistent infection of high-risk human papillomavirus (HR-HPV) plays a causal role in cervical cancer. Regulator of chromosome conde …
Exome sequencing and case-control analyses identify RCC1 as a candidate breast cancer susceptibility gene.
Riahi A, Radmanesh H, Schürmann P, Bogdanova N, Geffers R, Meddeb R, Kharrat M, Dörk T. Riahi A, et al. Int J Cancer. 2018 Jun 15;142(12):2512-2517. doi: 10.1002/ijc.31273. Epub 2018 Feb 5. Int J Cancer. 2018. PMID: 29363114 Free article.
To elucidate the molecular basis of breast cancer in the Tunisian population, we performed exome sequencing on six BRCA1/BRCA2 mutation-negative patients with familial breast cancer and identified a novel frameshift mutation in RCC1, encoding the Regulator of …
To elucidate the molecular basis of breast cancer in the Tunisian population, we performed exome sequencing on six BRCA1/BRCA2 mutati …
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
Mao X, Sethi G, Zhang Z, Wang Q. Mao X, et al. Curr Pharm Des. 2018;24(15):1676-1681. doi: 10.2174/1381612824666180528081024. Curr Pharm Des. 2018. PMID: 29807510 Review.
METHODS: The PubMed database was searched by keywords of individual HERC proteins (such as HERC4) and cancer. The emerging roles of HERC proteins in cancer and the specific mechanisms were collectively analyzed and discussed. ...CONCLUSION: HERC proteins as ubiquiti …
METHODS: The PubMed database was searched by keywords of individual HERC proteins (such as HERC4) and cancer. The emerging roles of H …
133 results