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2018 1
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2023 2
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RFTN1 facilitates gastric cancer progression by modulating AKT/p38 signaling pathways.
Deng C, Zhang L, Ma X, Cai S, Jia Y, Zhao L. Deng C, et al. Pathol Res Pract. 2022 Jun;234:153902. doi: 10.1016/j.prp.2022.153902. Epub 2022 Apr 18. Pathol Res Pract. 2022. PMID: 35490655
Furthermore, cell derived xenograft experiments showed that knockdown of RFTN1 inhibited GC cell growth in vivo. Notably, our experimental data demonstrated that knockdown of RFTN1 could inhibit the AKT signaling pathway and activate p38 signaling pathway, whereas o …
Furthermore, cell derived xenograft experiments showed that knockdown of RFTN1 inhibited GC cell growth in vivo. Notably, our experim …
Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer.
Ma C, Zhao J, Wu Y, Wang J, Wang H. Ma C, et al. Oncol Lett. 2022 May 16;24(1):209. doi: 10.3892/ol.2022.13330. eCollection 2022 Jul. Oncol Lett. 2022. PMID: 35720498 Free PMC article.
Changes in chromosome 3p (chr3) genes are usually observed in the pathogenesis of lung cancer, which suggests that these chr3 genes may be a diagnostic marker in the early stage of SCLC. ...CDC25A was overexpressed in SCLC samples, while FYCO1 and RFTN1 were highly …
Changes in chromosome 3p (chr3) genes are usually observed in the pathogenesis of lung cancer, which suggests that these chr3 genes m …
Genome-Wide Association Study of Smoking Behavior Traits in a Chinese Han Population.
Li M, Chen Y, Yao J, Lu S, Guan Y, Xu Y, Liu Q, Sun S, Mi Q, Mei J, Li X, Miao M, Zhao S, Zhu Z. Li M, et al. Front Psychiatry. 2020 Sep 9;11:564239. doi: 10.3389/fpsyt.2020.564239. eCollection 2020. Front Psychiatry. 2020. PMID: 33033484 Free PMC article.

Thirteen single-nucleotide polymorphisms (SNPs) of the raftlin lipid linker 1 (RFTN1) gene achieved genome-wide significance levels (P < 5 x 10(-8)) for smoking initiation. ...When treating males separately, associations between smoking initiation and PCAT5/ANKRD30A, tw

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Thirteen single-nucleotide polymorphisms (SNPs) of the raftlin lipid linker 1 (RFTN1) gene achieved genome-wide significance levels ( …
Multi-omics analysis of genomics, epigenomics and transcriptomics for molecular subtypes and core genes for lung adenocarcinoma.
Zhao Y, Gao Y, Xu X, Zhou J, Wang H. Zhao Y, et al. BMC Cancer. 2021 Mar 9;21(1):257. doi: 10.1186/s12885-021-07888-4. BMC Cancer. 2021. PMID: 33750346 Free PMC article.
BACKGROUND: Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explore molecular subtypes and core genes for LUAD using multi-omics analysis. ...Two multi-omics-based core genes (CNTN4 and RFTN1) could …
BACKGROUND: Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explo …
lncRNA- RP11-156p1.3, novel diagnostic and therapeutic targeting via CRISPR/Cas9 editing in hepatocellular carcinoma.
Ali HS, Boshra MS, El Meteini MS, Shafei AE, Matboli M. Ali HS, et al. Genomics. 2020 Sep;112(5):3306-3314. doi: 10.1016/j.ygeno.2020.06.020. Epub 2020 Jun 13. Genomics. 2020. PMID: 32544548 Free article.
In a proof-of-principle approach, CRISPR cas9 mediated knock out for lncRNA- RP11-156p1.3 was performed in HEPG2 cell line to validate the role of the chosen RNA in HCC pathogenesis. The differential expression of RFTN1 mRNA, lncRNA- RP11-156p1.3 and miRNA-4764-5p was stat …
In a proof-of-principle approach, CRISPR cas9 mediated knock out for lncRNA- RP11-156p1.3 was performed in HEPG2 cell line to validate the r …
Whole-genome sequencing identifies novel predictors for hematopoietic cell transplant outcomes for patients with myelodysplastic syndrome: a CIBMTR study.
Zhang T, Auer P, Dong J, Cutler C, Dezern AE, Gadalla SM, Deeg HJ, Nazha A, Carlson KS, Spellman S, Bolon YT, Saber W. Zhang T, et al. J Hematol Oncol. 2023 Apr 11;16(1):37. doi: 10.1186/s13045-023-01431-7. J Hematol Oncol. 2023. PMID: 37041565 Free PMC article.
Mutations in two novel genes, CHD1 and DDX11, demonstrated a negative impact on survival in AML/MDS and lymphoid cancer data from the Cancer Genome Atlas (TCGA). From unsupervised clustering of recurrent genomic alterations, genomic subgroup with TP53/del5q is chara …
Mutations in two novel genes, CHD1 and DDX11, demonstrated a negative impact on survival in AML/MDS and lymphoid cancer data from the …
Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors.
Moss RM, Sorajja N, Mills LJ, Moertel CL, Hoang TT, Spector LG, Largaespada DA, Williams LA. Moss RM, et al. Front Oncol. 2023 Mar 24;13:1113121. doi: 10.3389/fonc.2023.1113121. eCollection 2023. Front Oncol. 2023. PMID: 37035203 Free PMC article.
Unsupervised hierarchical clustering showed that sex-DMPs in SHH did not correlate with other tumor attributes. Ten genes with sex DMPs (RFTN1, C1orf103, FKBP1B, COL25A1, NPDC1, B3GNT1, FOXN3, RNASEH2C, TLE1, and PHF17) were shared across subgroups. ...In SHH, we identifie …
Unsupervised hierarchical clustering showed that sex-DMPs in SHH did not correlate with other tumor attributes. Ten genes with sex DMPs ( …
High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology.
Chong LC, Ben-Neriah S, Slack GW, Freeman C, Ennishi D, Mottok A, Collinge B, Abrisqueta P, Farinha P, Boyle M, Meissner B, Kridel R, Gerrie AS, Villa D, Savage KJ, Sehn LH, Siebert R, Morin RD, Gascoyne RD, Marra MA, Connors JM, Mungall AJ, Steidl C, Scott DW. Chong LC, et al. Blood Adv. 2018 Oct 23;2(20):2755-2765. doi: 10.1182/bloodadvances.2018023572. Blood Adv. 2018. PMID: 30348671 Free PMC article.
Genic cluster rearrangements were enriched for translocations involving IGH (80%), whereas nongenic rearrangements occurred mostly downstream of the MYC gene with a variety of partners, including IGL and IGK Other recurrent partners included BCL6, ZCCHC7, and RFTN1, which …
Genic cluster rearrangements were enriched for translocations involving IGH (80%), whereas nongenic rearrangements occurred mostly downstrea …