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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
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1993 2
1994 9
1995 11
1996 7
1997 25
1998 31
1999 34
2000 45
2001 54
2002 76
2003 87
2004 93
2005 95
2006 111
2007 109
2008 150
2009 161
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2011 179
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3,921 results

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Page 1
RHOA takes the RHOad less traveled to cancer.
Schaefer A, Der CJ. Schaefer A, et al. Trends Cancer. 2022 Aug;8(8):655-669. doi: 10.1016/j.trecan.2022.04.005. Epub 2022 May 12. Trends Cancer. 2022. PMID: 35568648 Review.
RAS and RHO GTPases function as signaling nodes that regulate diverse cellular processes. Whereas RAS mutations were identified in human cancers nearly four decades ago, only recently have mutations in two RHO GTPases, RAC1 and RHOA, been identified in cancer …
RAS and RHO GTPases function as signaling nodes that regulate diverse cellular processes. Whereas RAS mutations were identified in human …
TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway.
Wei X, Lou H, Zhou D, Jia Y, Li H, Huang Q, Ma J, Yang Z, Sun C, Meng Y, Xu S, Yang X, Li X, Ji T, Guo Z, Gao Q. Wei X, et al. J Exp Clin Cancer Res. 2021 Sep 19;40(1):292. doi: 10.1186/s13046-021-02091-6. J Exp Clin Cancer Res. 2021. PMID: 34538264 Free PMC article.
BACKGROUND: Ovarian cancer (OC) progression is an unmet medical challenge. Since omental metastases were palpated harder than their primary counterparts during cytoreductive surgery of patients with epithelial ovarian cancer (EOC), we were inspired to investigate OC …
BACKGROUND: Ovarian cancer (OC) progression is an unmet medical challenge. Since omental metastases were palpated harder than their p …
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.
Adua SJ, Arnal-Estapé A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert AE, Melnick MA, Hu B, Politi K, Chiang V, Colclough N, Goodwin RJA, Cross D, Smith P, Nguyen DX. Adua SJ, et al. Nat Commun. 2022 Dec 12;13(1):7690. doi: 10.1038/s41467-022-34889-z. Nat Commun. 2022. PMID: 36509758 Free PMC article.
RhoA potentiates the outgrowth of disseminated tumor cells on osimertinib treatment, preferentially in response to extracellular laminin and in the brain. Thus, we identify pre-existing and adaptive features of metastatic and drug-resistant cancer cells, which are e …
RhoA potentiates the outgrowth of disseminated tumor cells on osimertinib treatment, preferentially in response to extracellular lami …
WNT signaling and cancer stemness.
Katoh M, Katoh M. Katoh M, et al. Essays Biochem. 2022 Sep 16;66(4):319-331. doi: 10.1042/EBC20220016. Essays Biochem. 2022. PMID: 35837811 Free PMC article.
Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks. ...Noncanonical WNT signaling supports maintenance of slowly cycling, quiesce …
Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem cells (CSCs), is a cancer bi …
Extracellular fluid viscosity enhances cell migration and cancer dissemination.
Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, Paul CD, Sen A, Serra SA, Stoletov K, Tao J, Shatkin G, Lee SJ, Zhang Y, Boen A, Mistriotis P, Gilkes DM, Lewis JD, Fan CM, Feinberg AP, Valverde MA, Sun SX, Konstantopoulos K. Bera K, et al. Nature. 2022 Nov;611(7935):365-373. doi: 10.1038/s41586-022-05394-6. Epub 2022 Nov 2. Nature. 2022. PMID: 36323783 Free PMC article.
Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such as cancer(5). However, its influence on cancer biology and the mechanism by which cells sense and respond to changes in viscosity are unknown. ...Cu …
Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such as cancer(5). H …
Clinicopathological Significance of RhoA Expression in Digestive Tract Cancer: A Systematic Review and Meta-Analysis.
Wang P, Li W, Peng J, Qi S, Song L, Liu C, Li F. Wang P, et al. Clin Lab. 2016 Oct 1;62(10):1955-1964. doi: 10.7754/Clin.Lab.2016.160218. Clin Lab. 2016. PMID: 28164524 Review.
BACKGROUND: RhoA protein expression has been reported in different types of cancer. ...RhoA expression may play an important role in the carcinogenesis and metastasis of gastrointestinal cancer....
BACKGROUND: RhoA protein expression has been reported in different types of cancer. ...RhoA expression may play an impo …
RhoA, RhoB and RhoC have different roles in cancer cell migration.
Ridley AJ. Ridley AJ. J Microsc. 2013 Sep;251(3):242-9. doi: 10.1111/jmi.12025. Epub 2013 Mar 12. J Microsc. 2013. PMID: 23488932 Review.
Here I review the different ways in which RhoA, RhoB and RhoC expression is regulated in cancer and how they play distinct roles in cancer progression. I describe their main effectors known to contribute to cell motility. Recent results from our laboratory an …
Here I review the different ways in which RhoA, RhoB and RhoC expression is regulated in cancer and how they play distinct rol …
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.
Moose DL, Krog BL, Kim TH, Zhao L, Williams-Perez S, Burke G, Rhodes L, Vanneste M, Breheny P, Milhem M, Stipp CS, Rowat AC, Henry MD. Moose DL, et al. Cell Rep. 2020 Mar 17;30(11):3864-3874.e6. doi: 10.1016/j.celrep.2020.02.080. Cell Rep. 2020. PMID: 32187555 Free PMC article.
During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces including fluid shear stress (FSS) while en route to distant sites. ...Herein, we identify a mechano-adaptive mechanism of FSS resistance in cancer cells. Our findings demonstr …
During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces including fluid shear stress (FSS) while en …
The RhoA dependent anti-metastatic function of RKIP in breast cancer.
Kalpana G, Figy C, Feng J, Tipton C, De Castro JN, Bach VN, Borile C, LaSalla A, Odeh HN, Yeung M, Garcia-Mata R, Yeung KC. Kalpana G, et al. Sci Rep. 2021 Aug 31;11(1):17455. doi: 10.1038/s41598-021-96709-6. Sci Rep. 2021. PMID: 34465801 Free PMC article.
RhoA has both a pro- and anti-metastatic cell-context dependent functions. Given that Rho GTPases primarily function on actin cytoskeleton dynamics and cell movement regulation, it is possible that one way RKIP hinders cancer cell invasion/metastasis is by targeting …
RhoA has both a pro- and anti-metastatic cell-context dependent functions. Given that Rho GTPases primarily function on actin cytoske …
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. Limzerwala JF, et al. Nat Cancer. 2020 Oct;1(10):1010-1024. doi: 10.1038/s43018-020-00116-1. Epub 2020 Oct 12. Nat Cancer. 2020. PMID: 34841254 Free PMC article.
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multiple cancers. Here we identify FoxM1 as a tumor suppressor in mice that, through its N-terminal domain, binds to and inhibits Ect2 to …
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multi …
3,921 results