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Page 1
The Role of RhoH in TCR Signalling and Its Involvement in Diseases.
Ahmad Mokhtar AM, Hashim IF, Mohd Zaini Makhtar M, Salikin NH, Amin-Nordin S. Ahmad Mokhtar AM, et al. Cells. 2021 Apr 20;10(4):950. doi: 10.3390/cells10040950. Cells. 2021. PMID: 33923951 Free PMC article. Review.
To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells. ...As such, RhoH and its associated proteins are potential attack points, especially in the treatment of cancer and immune-related d …
To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells. ...As …
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.
Tajadura-Ortega V, Garg R, Allen R, Owczarek C, Bright MD, Kean S, Mohd-Noor A, Grigoriadis A, Elston TC, Hahn KM, Ridley AJ. Tajadura-Ortega V, et al. BMC Biol. 2018 Mar 6;16(1):29. doi: 10.1186/s12915-018-0489-4. BMC Biol. 2018. PMID: 29510700 Free PMC article.
High RhoH expression in samples from prostate cancer patients correlates with earlier relapse. ...Our results also suggest that RhoH expression levels correlate with prostate cancer progression....
High RhoH expression in samples from prostate cancer patients correlates with earlier relapse. ...Our results also suggest tha …
Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
Horiguchi H, Xu H, Duvert B, Ciuculescu F, Yao Q, Sinha A, McGuinness M, Harris C, Brendel C, Troeger A, Chiarle R, Williams DA. Horiguchi H, et al. Small GTPases. 2022 Jan;13(1):267-281. doi: 10.1080/21541248.2021.2019503. Small GTPases. 2022. PMID: 34983288 Free PMC article.
However, the effects of RHOH mutations and translocations on RhoH expression and malignant transformation remain unknown. ...Re-expression of RhoH in Rhoh(KO)Bcl-6(Tg) lymphoma cell lines reversed these changes in expression profile and reduced prolife …
However, the effects of RHOH mutations and translocations on RhoH expression and malignant transformation remain unknown. ...R …
Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
Porubsky S, Wang S, Kiss E, Dehmel S, Bonrouhi M, Dorn T, Luckow B, Brakebusch C, Gröne HJ. Porubsky S, et al. Eur J Immunol. 2011 Jan;41(1):76-88. doi: 10.1002/eji.201040420. Epub 2010 Nov 11. Eur J Immunol. 2011. PMID: 21182079 Free article.
Rhoh is a hematopoietic system-specific GTPase. Rhoh-deficient T cells have been shown to have a defect in TCR signaling manifested during their thymic development. ...Antigen uptake and presentation in DC were unaffected by Rhoh deficiency. These findings st …
Rhoh is a hematopoietic system-specific GTPase. Rhoh-deficient T cells have been shown to have a defect in TCR signaling manif …
Repression of the RHOH gene by JunD.
Delestré L, Berthon C, Quesnel B, Figeac M, Kerckaert JP, Galiègue-Zouitina S, Shelley CS. Delestré L, et al. Biochem J. 2011 Jul 1;437(1):75-88. doi: 10.1042/BJ20100829. Biochem J. 2011. PMID: 21473742
Transcription of the RHOH gene is the first level at which the quantitative levels of the RhoH protein are regulated. ...This downstream target of RHOH is also induced in AML cells by JUND inhibition. Collectively, these data indicate that JunD is an inhibito …
Transcription of the RHOH gene is the first level at which the quantitative levels of the RhoH protein are regulated. ...This …
RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells.
Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu MF, Williams DA. Mino A, et al. Small GTPases. 2018 May 4;9(3):260-273. doi: 10.1080/21541248.2016.1220780. Epub 2016 Aug 31. Small GTPases. 2018. PMID: 27574848 Free PMC article.
To further elucidate the molecular mechanisms of RhoH in T cell function, we carried out in vivo biotinylation and mass spectrometry analysis to identify new RhoH-interacting proteins in Jurkat T cells. ...Using RhoH knockdown we demonstrated that Kaiso local …
To further elucidate the molecular mechanisms of RhoH in T cell function, we carried out in vivo biotinylation and mass spectrometry …
[Expression Difference of RhoH Gene in Leukemia and Its Clinical Significance].
Ni J, Shi QQ, Wu W, Sun X, Fang YZ, Gu J. Ni J, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Jun;27(3):758-762. doi: 10.19746/j.cnki.issn.1009-2137.2019.03.019. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019. PMID: 31204928 Chinese.
The median expression level of RhoH was used as the cut-off value. The newly diagnosed patients were divided into RhoH high expression group and low expression group. ...In ALL, RhoH may participate in the disease process through other mechanism....
The median expression level of RhoH was used as the cut-off value. The newly diagnosed patients were divided into RhoH high ex …
Bimodal expression of RHOH during myelomonocytic differentiation: Implications for the expansion of AML differentiation therapy.
Galiègue-Zouitina S, Fu Q, Carton-Latreche C, Poret N, Cheok M, Leprêtre F, Figeac M, Quesnel B, El Bouazzati H, Shelley CS. Galiègue-Zouitina S, et al. EJHaem. 2021 Jan 20;2(2):196-210. doi: 10.1002/jha2.128. eCollection 2021 May. EJHaem. 2021. PMID: 35845268 Free PMC article.
RhoH is an unusual member of the Rho family of small GTP-binding proteins in that it lacks GTPase activity. ...Here we investigate how myeloid differentiation is controlled by the quantitative expression of RHOH. Our analysis demonstrates that increasingly mature my …
RhoH is an unusual member of the Rho family of small GTP-binding proteins in that it lacks GTPase activity. ...Here we investigate ho …
The pseudoGTPase group of pseudoenzymes.
Stiegler AL, Boggon TJ. Stiegler AL, et al. FEBS J. 2020 Oct;287(19):4232-4245. doi: 10.1111/febs.15554. Epub 2020 Sep 17. FEBS J. 2020. PMID: 32893973 Free PMC article. Review.
Among the pseudoenzymes, the pseudoGTPase group of atypical GTPases has recently expanded and includes the Rnd and RGK groups, RhoH and the RhoBTB proteins, mitochondrial RhoGTPase and centaurin-gamma groups, CENP-M, dynein LIC, Entamoeba histolytica RabX3, leucine-rich re …
Among the pseudoenzymes, the pseudoGTPase group of atypical GTPases has recently expanded and includes the Rnd and RGK groups, RhoH a …
The small GTPase RhoH is an atypical regulator of haematopoietic cells.
Fueller F, Kubatzky KF. Fueller F, et al. Cell Commun Signal. 2008 Sep 29;6:6. doi: 10.1186/1478-811X-6-6. Cell Commun Signal. 2008. PMID: 18823547 Free PMC article.
Since then, RhoH has been implicated in human cancer as the gene is subject to somatic hypermutation and by the detection of RHOH as a translocation partner for LAZ3/BCL6 or other genes in human lymphomas. ...However, RhoH-deficient mice did not develo …
Since then, RhoH has been implicated in human cancer as the gene is subject to somatic hypermutation and by the detection of …
73 results