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Year Number of Results
1997 2
1998 2
1999 2
2000 6
2001 4
2002 1
2003 8
2004 9
2005 2
2006 6
2007 7
2008 5
2009 7
2010 11
2011 7
2012 10
2013 12
2014 27
2015 42
2016 54
2017 51
2018 67
2019 64
2020 83
2021 83
2022 86
2023 100
2024 42

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705 results

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Page 1
The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade.
Cucolo L, Chen Q, Qiu J, Yu Y, Klapholz M, Budinich KA, Zhang Z, Shao Y, Brodsky IE, Jordan MS, Gilliland DG, Zhang NR, Shi J, Minn AJ. Cucolo L, et al. Immunity. 2022 Apr 12;55(4):671-685.e10. doi: 10.1016/j.immuni.2022.03.007. Immunity. 2022. PMID: 35417675 Free article.
Genetic interaction screening revealed that in cancer cells, RIPK1 diverted TNF signaling through NF-kappaB and away from its role in cell death. ...Thus, cancer cells co-opt RIPK1 to promote cell-intrinsic and cell-extrinsic resistance to immunotherap …
Genetic interaction screening revealed that in cancer cells, RIPK1 diverted TNF signaling through NF-kappaB and away from its …
ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.
Baik JY, Liu Z, Jiao D, Kwon HJ, Yan J, Kadigamuwa C, Choe M, Lake R, Kruhlak M, Tandon M, Cai Z, Choksi S, Liu ZG. Baik JY, et al. Nat Commun. 2021 May 11;12(1):2666. doi: 10.1038/s41467-021-23004-3. Nat Commun. 2021. PMID: 33976222 Free PMC article.
Here, we report that Z-DNA-binding protein 1 (ZBP1), not RIPK1, mediates tumor necroptosis during tumor development in preclinical cancer models. We found that ZBP1 expression is dramatically elevated in necrotic tumors. Importantly, ZBP1, not RIPK1, deletion …
Here, we report that Z-DNA-binding protein 1 (ZBP1), not RIPK1, mediates tumor necroptosis during tumor development in preclinical …
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1.
Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, Lee YR, Pan L, Shaw RJ, Yuan J, Wei W. Zhang T, et al. Science. 2023 Jun 30;380(6652):1372-1380. doi: 10.1126/science.abn1725. Epub 2023 Jun 29. Science. 2023. PMID: 37384704 Free PMC article.
We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, whereas AMPK inhibited RIPK1 by phosphorylation at Ser(415) to suppress energy stress-induced cell death. Inhibiting pS415-RIPK1 by …
We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, wherea …
The role of necroptosis in cancer biology and therapy.
Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C. Gong Y, et al. Mol Cancer. 2019 May 23;18(1):100. doi: 10.1186/s12943-019-1029-8. Mol Cancer. 2019. PMID: 31122251 Free PMC article. Review.
Necroptosis also reportedly promotes oncogenesis and cancer metastasis despite evidence demonstrating its antimetastatic role in cancer. ...We also summarize the intricate role of necroptosis in tumor progression, cancer metastasis, prognosis of cancer …
Necroptosis also reportedly promotes oncogenesis and cancer metastasis despite evidence demonstrating its antimetastatic role in c …
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).
Samir P, Malireddi RKS, Kanneganti TD. Samir P, et al. Front Cell Infect Microbiol. 2020 Jun 3;10:238. doi: 10.3389/fcimb.2020.00238. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32582562 Free PMC article. Review.
The PANoptosome components have been implicated in a wide array of human diseases including autoinflammatory diseases, neurodegenerative diseases, cancer, microbial infections, and metabolic diseases. Here, we review putative components of the PANoptosome and present a phy …
The PANoptosome components have been implicated in a wide array of human diseases including autoinflammatory diseases, neurodegenerative dis …
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation.
Zhang T, Xu D, Liu J, Wang M, Duan LJ, Liu M, Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, Lee YR, Pan L, Kaelin WG Jr, Yuan J, Wei W. Zhang T, et al. Nat Cell Biol. 2023 Jul;25(7):950-962. doi: 10.1038/s41556-023-01170-4. Epub 2023 Jul 3. Nat Cell Biol. 2023. PMID: 37400498 Free PMC article.
Prolyl hydroxylation of RIPK1 mediated by EGLN1 promotes the binding of RIPK1 with pVHL to suppress its activation under normoxic conditions. ...As such, inhibiting proline hydroxylation of RIPK1 promotes RIPK1 activation to trigger cell death and infl …
Prolyl hydroxylation of RIPK1 mediated by EGLN1 promotes the binding of RIPK1 with pVHL to suppress its activation under normo …
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
Peng R, Wang CK, Wang-Kan X, Idorn M, Kjaer M, Zhou FY, Fiil BK, Timmermann F, Orozco SL, McCarthy J, Leung CS, Lu X, Bagola K, Rehwinkel J, Oberst A, Maelfait J, Paludan SR, Gyrd-Hansen M. Peng R, et al. EMBO Rep. 2022 Dec 6;23(12):e55839. doi: 10.15252/embr.202255839. Epub 2022 Oct 21. EMBO Rep. 2022. PMID: 36268590 Free PMC article.
Here, we report a ZBP1-induced inflammatory signaling pathway mediated by K63- and M1-linked ubiquitin chains, which depends on RIPK1 and RIPK3 as scaffolds independently of cell death. In human HT29 cells, ZBP1 associated with RIPK1 and RIPK3 as well as ubiquitin l …
Here, we report a ZBP1-induced inflammatory signaling pathway mediated by K63- and M1-linked ubiquitin chains, which depends on RIPK1 …
RIPK1 and RIPK3 are positive prognosticators for cervical cancer patients and C2 ceramide can inhibit tumor cell proliferation in vitro.
Vogelsang TLR, Kast V, Bagnjuk K, Eubler K, Jeevanandan SP, Schmoeckel E, Trebo A, Topalov NE, Mahner S, Mayr D, Mayerhofer A, Jeschke U, Vattai A. Vogelsang TLR, et al. Front Oncol. 2023 May 1;13:1110939. doi: 10.3389/fonc.2023.1110939. eCollection 2023. Front Oncol. 2023. PMID: 37197430 Free PMC article.
METHODS: The expression of RIPK1, RIPK3, and pMLKL in cervical cancer tissue microarrays of n = 250 patients was analyzed immunohistochemically. ...RESULTS: Significantly longer overall survival and progression-free survival rates could be detected in cervical ca …
METHODS: The expression of RIPK1, RIPK3, and pMLKL in cervical cancer tissue microarrays of n = 250 patients was analyzed immu …
AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells.
You B, Xia T, Gu M, Zhang Z, Zhang Q, Shen J, Fan Y, Yao H, Pan S, Lu Y, Cheng T, Yang Z, He X, Zhang H, Shi M, Liu D, You Y. You B, et al. Cancer Res. 2022 Mar 1;82(5):846-858. doi: 10.1158/0008-5472.CAN-21-2342. Cancer Res. 2022. PMID: 34965934 Free PMC article.
Dormant cancer cells that survive anticancer therapy can lead to cancer recurrence and disseminated metastases that prove fatal in most cases. ...Analysis of the transcriptional and epigenetic landscape of PGCC revealed overexpression of RIPK1, and the scaffo …
Dormant cancer cells that survive anticancer therapy can lead to cancer recurrence and disseminated metastases that prove fata …
Sublethal necroptosis signaling promotes inflammation and liver cancer.
Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T. Vucur M, et al. Immunity. 2023 Jul 11;56(7):1578-1595.e8. doi: 10.1016/j.immuni.2023.05.017. Epub 2023 Jun 16. Immunity. 2023. PMID: 37329888 Free article.
705 results