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65 results

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Page 1
Rare molecular subtypes of lung cancer.
Harada G, Yang SR, Cocco E, Drilon A. Harada G, et al. Nat Rev Clin Oncol. 2023 Apr;20(4):229-249. doi: 10.1038/s41571-023-00733-6. Epub 2023 Feb 20. Nat Rev Clin Oncol. 2023. PMID: 36806787 Free PMC article. Review.
Oncogenes that occur in 5% of non-small-cell lung cancers have been defined as 'rare'; nonetheless, this frequency can correspond to a substantial number of patients diagnosed annually. ...In tandem, the number of approved targeted therapies for patients with rare molecula …
Oncogenes that occur in 5% of non-small-cell lung cancers have been defined as 'rare'; nonetheless, this frequency can correspond to …
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH. Vichas A, et al. Nat Commun. 2021 Aug 9;12(1):4789. doi: 10.1038/s41467-021-24841-y. Nat Commun. 2021. PMID: 34373451 Free PMC article.
To identify opportunities for therapeutic intervention in other rarer subsets of cancer, we investigate the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Here, genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant is …
To identify opportunities for therapeutic intervention in other rarer subsets of cancer, we investigate the oncogene-specific depende …
Comprehensive molecular profiling of lung adenocarcinoma.
Cancer Genome Atlas Research Network. Cancer Genome Atlas Research Network. Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9. Nature. 2014. PMID: 25079552 Free PMC article.
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. ...Eighteen …
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung ad …
Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer.
Xu F, Sun S, Yan S, Guo H, Dai M, Teng Y. Xu F, et al. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10315-24. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26617739 Free PMC article.
The purpose of the current study was to characterize the expression pattern of RIT1 and assess the clinical significance of RIT1 expression in endometrial cancer patients. ...In addition, RIT1 mRNA expression was elevated in 36 freshly frozen endometri …
The purpose of the current study was to characterize the expression pattern of RIT1 and assess the clinical significance of RIT1 …
RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.
Su Y, Lin H, Yu J, Mao L, Jin W, Liu T, Jiang S, Wu Y, Zhang S, Geng Q, Ge C, Zhao F, Chen T, Cui Y, Li J, Hou H, Zhou X, Li H. Su Y, et al. J Exp Clin Cancer Res. 2023 Nov 29;42(1):326. doi: 10.1186/s13046-023-02892-x. J Exp Clin Cancer Res. 2023. PMID: 38017479 Free PMC article.
SMC3 is found to interact with RIT1 and knockdown of SMC3 attenuates the proliferative effects mediated by RIT1 both in vitro and in vivo. ...Furthermore, there is a significant positive correlation between the expression levels of RIT1, SMC3, and PDS5. Impor …
SMC3 is found to interact with RIT1 and knockdown of SMC3 attenuates the proliferative effects mediated by RIT1 both in vitro …
RIT1 oncoproteins escape LZTR1-mediated proteolysis.
Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. Castel P, et al. Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444. Science. 2019. PMID: 30872527 Free PMC article.
RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. ...Pathogenic mutations affecting either RIT1 or LZTR1 resulted in incomplete degradation of RIT1. This led to RIT1 accumulation and dysregulated growth factor …
RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. ...Pathogenic mutations affecting either …
Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer.
Riley AK, Berger AH. Riley AK, et al. Mol Cell Oncol. 2021 Nov 16;8(6):2000318. doi: 10.1080/23723556.2021.2000318. eCollection 2021. Mol Cell Oncol. 2021. PMID: 35419481 Free PMC article.
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in o …
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT …
The molecular functions of RIT1 and its contribution to human disease.
Van R, Cuevas-Navarro A, Castel P, McCormick F. Van R, et al. Biochem J. 2020 Aug 14;477(15):2755-2770. doi: 10.1042/BCJ20200442. Biochem J. 2020. PMID: 32766847 Free PMC article. Review.
Emerging clinical evidences have now demonstrated a role for RIT1 in RASopathies, namely Noonan syndrome, and various cancers including lung adenocarcinoma and myeloid malignancies. ...Deeper understanding of RIT1 biological function and insight to its pathog …
Emerging clinical evidences have now demonstrated a role for RIT1 in RASopathies, namely Noonan syndrome, and various cancers …
NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1alpha/RIT1 signaling pathway.
Tian Y, Shao L, Wang Q, Ru G, Zhai C, Zhou L. Tian Y, et al. Open Med (Wars). 2023 May 16;18(1):20230700. doi: 10.1515/med-2023-0700. eCollection 2023. Open Med (Wars). 2023. PMID: 37215053 Free PMC article.
Besides, knockdown of NECAB3 suppressed the activation of the hypoxia-inducible factor 1-alpha (HIF-1alpha)/Ras like without CAAX 1 (RIT1) pathway. Furthermore, NECAB3 regulated liver cancer migration and invasion through modulating RIT1 expression. ...Knockd …
Besides, knockdown of NECAB3 suppressed the activation of the hypoxia-inducible factor 1-alpha (HIF-1alpha)/Ras like without CAAX 1 (RIT1 …
HIF-1alpha-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib.
Song Z, Liu T, Chen J, Ge C, Zhao F, Zhu M, Chen T, Cui Y, Tian H, Yao M, Li J, Li H. Song Z, et al. Cancer Lett. 2019 Sep 28;460:96-107. doi: 10.1016/j.canlet.2019.06.016. Epub 2019 Jun 24. Cancer Lett. 2019. PMID: 31247273
However, little is known about the roles of RIT1 in hepatocellular carcinoma (HCC). Here we found that RIT1 expression was positively associated with the presence of intrahepatic metastasis and the histological grade of HCC and higher RIT1 expression indicate …
However, little is known about the roles of RIT1 in hepatocellular carcinoma (HCC). Here we found that RIT1 expression was pos …
65 results