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14 results

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Page 1
RNF26 Promotes Pancreatic Cancer Proliferation by Enhancing RBM38 Degradation.
Lu X, Zhang Y, Wu Y, Lu T, Yang H, Yang W, Pang B, Yang C. Lu X, et al. Pancreas. 2022 Nov-Dec 01;51(10):1427-1433. doi: 10.1097/MPA.0000000000002183. Epub 2023 Mar 7. Pancreas. 2022. PMID: 37099788
OBJECTIVES: RING finger protein 26 (RNF26) plays an essential role in determining malignant tumor growth, whereas the role of which in pancreatic cancer (PC) has not been reported. ...Furthermore, we demonstrated RNF26 degraded RBM38 to promote PC cell prolif …
OBJECTIVES: RING finger protein 26 (RNF26) plays an essential role in determining malignant tumor growth, whereas the role of which i …
The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Yi L, Wang H, Li W, Ye K, Xiong W, Yu H, Jin X. Yi L, et al. Cell Death Dis. 2021 Oct 14;12(10):944. doi: 10.1038/s41419-021-04260-z. Cell Death Dis. 2021. PMID: 34650035 Free PMC article.
Here, bioinformatics analysis demonstrated that RNF26 was one of the risk factors for bladder cancer. Then, we showed that RNF26 is abnormally upregulated in bladder cancer cells and tissues and that higher RNF26 expression is an unfavorable pro …
Here, bioinformatics analysis demonstrated that RNF26 was one of the risk factors for bladder cancer. Then, we showed that …
The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC.
Liu W, Wang H, Jian C, Li W, Ye K, Ren J, Zhu L, Wang Y, Jin X, Yi L. Liu W, et al. Int J Biol Sci. 2022 Feb 28;18(5):2132-2145. doi: 10.7150/ijbs.69325. eCollection 2022. Int J Biol Sci. 2022. PMID: 35342353 Free PMC article.
Moreover, we found that CBX7 was a bona fide substrate of RNF26. RNF26 promoted the degradation of CBX7 and enhanced ccRCC tumor growth. Therefore, our results revealed a novel RNF26/CBX7 axis that modulates the TNF signaling pathway in ccRCC....
Moreover, we found that CBX7 was a bona fide substrate of RNF26. RNF26 promoted the degradation of CBX7 and enhanced ccRCC tum …
Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper.
Katoh M. Katoh M. Biochem Biophys Res Commun. 2001 Apr 13;282(4):1038-44. doi: 10.1006/bbrc.2001.4671. Biochem Biophys Res Commun. 2001. PMID: 11352657
The 3.2-kb RNF26 mRNA was expressed ubiquitously in normal human tissues, but was upregulated in several human cancer cell lines, including HL-60 (promyelocytic leukemia), HeLa S3 (cervical uterus cancer), SW480 (colorectal cancer), and MKN7 (gastric …
The 3.2-kb RNF26 mRNA was expressed ubiquitously in normal human tissues, but was upregulated in several human cancer cell lin …
Mechanisms of lysosomal positioning and movement.
Cabukusta B, Neefjes J. Cabukusta B, et al. Traffic. 2018 Oct;19(10):761-769. doi: 10.1111/tra.12587. Epub 2018 Jul 17. Traffic. 2018. PMID: 29900632 Free PMC article. Review.
Therefore, it is not surprising that lysosomal dysfunction underlies various diseases, including cancer, neurodegenerative and autoimmune diseases. In most of these biological events, the involvement of lysosomes is dependent on their ability to move throughout the cytopla …
Therefore, it is not surprising that lysosomal dysfunction underlies various diseases, including cancer, neurodegenerative and autoim …
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.
Jongsma ML, Berlin I, Wijdeven RH, Janssen L, Janssen GM, Garstka MA, Janssen H, Mensink M, van Veelen PA, Spaapen RM, Neefjes J. Jongsma ML, et al. Cell. 2016 Jun 30;166(1):152-66. doi: 10.1016/j.cell.2016.05.078. Cell. 2016. PMID: 27368102 Free PMC article.
Consequently, RNF26 restrains fast transport of diverse vesicles through a common molecular mechanism operating at the ER membrane, until the deubiquitinating enzyme USP15 opposes RNF26 activity to allow vesicle release into the cell's periphery. By drawing the endo …
Consequently, RNF26 restrains fast transport of diverse vesicles through a common molecular mechanism operating at the ER membrane, u …
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren's syndrome.
Huijser E, Bodewes ILA, Lourens MS, van Helden-Meeuwsen CG, van den Bosch TPP, Grashof DGB, van de Werken HJG, Lopes AP, van Roon JAG, van Daele PLA, Brkic Z, Dik WA, Versnel MA. Huijser E, et al. Rheumatology (Oxford). 2022 Aug 3;61(8):3491-3496. doi: 10.1093/rheumatology/keac016. Rheumatology (Oxford). 2022. PMID: 35022662 Free PMC article.
Positive STING regulators TRIM38, TRIM56, USP18 and SENP7 were significantly higher expression in pSS than HC monocytes, while the dual-function STING regulator RNF26 was downregulated in pSS monocytes. STING was expressed in mononuclear infiltrates and ductal epithelium i …
Positive STING regulators TRIM38, TRIM56, USP18 and SENP7 were significantly higher expression in pSS than HC monocytes, while the dual-func …
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
Fenech EJ, Lari F, Charles PD, Fischer R, Laétitia-Thézénas M, Bagola K, Paton AW, Paton JC, Gyrd-Hansen M, Kessler BM, Christianson JC. Fenech EJ, et al. Elife. 2020 Jul 2;9:e57306. doi: 10.7554/eLife.57306. Elife. 2020. PMID: 32614325 Free PMC article.
RNF26 co-assembles with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune signalling through the cGAS-STING pathway. This RNF26 complex represents a new modulatory axis of STING and innate immune signalling at the ER membrane. .. …
RNF26 co-assembles with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune signalling through the …
Fine mapping and evaluation of candidate genes for cervical cancer on 11q23.
Zhang Z, Gerhard DS, Nguyen L, Li J, Traugott A, Huettner PC, Rader JS. Zhang Z, et al. Genes Chromosomes Cancer. 2005 May;43(1):95-103. doi: 10.1002/gcc.20151. Genes Chromosomes Cancer. 2005. PMID: 15672406
We previously showed that loss of heterozygosity (LOH) at 11q23 is a common genetic alteration in cervical cancer (CC) and that it correlates with extensive invasion of lymph-vascular spaces. ...Our results indicate that a major region of LOH in cervical cancer exis …
We previously showed that loss of heterozygosity (LOH) at 11q23 is a common genetic alteration in cervical cancer (CC) and that it co …
USP17 is required for peripheral trafficking of lysosomes.
Lin J, McCann AP, Sereesongsaeng N, Burden JM, Alsa'd AA, Burden RE, Micu I, Williams R, Van Schaeybroeck S, Evergren E, Mullan P, Simpson JC, Scott CJ, Burrows JF. Lin J, et al. EMBO Rep. 2022 Apr 5;23(4):e51932. doi: 10.15252/embr.202051932. Epub 2022 Jan 26. EMBO Rep. 2022. PMID: 35080333 Free PMC article.
Finally, we demonstrate that USP17 can deubiquitinate p62, and we propose that USP17 can facilitate peripheral lysosome trafficking by opposing the E3 ligase RNF26 to untether lysosomes from the ER and facilitate lysosome peripheral trafficking, lysosome protease secretion …
Finally, we demonstrate that USP17 can deubiquitinate p62, and we propose that USP17 can facilitate peripheral lysosome trafficking by oppos …
14 results