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109 results

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RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
Novak R, Ahmad YA, Timaner M, Bitman-Lotan E, Oknin-Vaisman A, Horwitz R, Hartmann O, Reissland M, Buck V, Rosenfeldt M, Nikomarov D, Diefenbacher ME, Shaked Y, Orian A. Novak R, et al. Cell Death Dis. 2022 Sep 24;13(9):820. doi: 10.1038/s41419-022-05262-1. Cell Death Dis. 2022. PMID: 36153321 Free PMC article.
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer. We report that the RNF4 ubiquitin ligase is essential for OD of hBM …
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for reg …
RNF4-A Paradigm for SUMOylation-Mediated Ubiquitination.
Kumar R, Sabapathy K. Kumar R, et al. Proteomics. 2019 Nov;19(21-22):e1900185. doi: 10.1002/pmic.201900185. Epub 2019 Oct 29. Proteomics. 2019. PMID: 31566917 Review.
The SUMO-Targeted Ubiquitin Ligases (STUbL) mediate this process, and RNF4, the mammalian STUbL, has been at the forefront in the understanding of this phenomenon. ...Moreover, the potential of therapeutically targeting RNF4 to improve cancer treatment is als …
The SUMO-Targeted Ubiquitin Ligases (STUbL) mediate this process, and RNF4, the mammalian STUbL, has been at the forefront in the und …
RNF4 controls the extent of replication fork reversal to preserve genome stability.
Ding L, Luo Y, Tian T, Chen X, Yang Y, Bu M, Han J, Yang B, Yan H, Liu T, Wu M, Zhang G, Xu Y, Zhu S, Huen MSY, Mao G, Huang J. Ding L, et al. Nucleic Acids Res. 2022 Jun 10;50(10):5672-5687. doi: 10.1093/nar/gkac447. Nucleic Acids Res. 2022. PMID: 35640614 Free PMC article.
Here we show that, upon replication stress, the SUMO-targeted ubiquitin E3 ligase RNF4 accumulates at stalled forks and targets SUMOylated TOP2A for ubiquitination and degradation. Downregulation of RNF4 resulted in aberrant activation of the ZATT-TOP2A-PICH complex …
Here we show that, upon replication stress, the SUMO-targeted ubiquitin E3 ligase RNF4 accumulates at stalled forks and targets SUMOy …
RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.
Her J, Zheng H, Bunting SF. Her J, et al. J Clin Invest. 2024 Mar 26;134(10):e167419. doi: 10.1172/JCI167419. J Clin Invest. 2024. PMID: 38530355 Free PMC article.
Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of somatic cells. Although Rnf4-conditional-knockout B cells exhibited substantial genomic instability, Rnf4 deletion caused no in …
Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of s …
RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPalpha axis.
Wang L, Liu X, Wang H, Yuan H, Chen S, Chen Z, de The H, Zhou J, Zhu J. Wang L, et al. FASEB J. 2018 Sep;32(9):4930-4940. doi: 10.1096/fj.201701450RR. Epub 2018 Apr 10. FASEB J. 2018. PMID: 29634367
We generated a zebrafish rnf4 knockout line by using transcription activator-like effector nucleases technology to address the impact of rnf4 during hematopoiesis. ...Collectively, RNF4 is indispensable for zebrafish granulopoiesis through regulation of the D …
We generated a zebrafish rnf4 knockout line by using transcription activator-like effector nucleases technology to address the impact …
RNF4-Dependent Oncogene Activation by Protein Stabilization.
Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A. Thomas JJ, et al. Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024. Cell Rep. 2016. PMID: 27653698 Free PMC article.
Stabilization also involves generation of unusual polyubiquitin chains and docking of RNF4 to chromatin. Biologically, RNF4 enhances the tumor phenotype and is essential for cancer cell survival. High levels of RNF4 mRNA correlate with poor survival of …
Stabilization also involves generation of unusual polyubiquitin chains and docking of RNF4 to chromatin. Biologically, RNF4 en …
Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer.
Diefenbacher M, Orian A. Diefenbacher M, et al. Mol Cell Oncol. 2016 Nov 18;4(1):e1260671. doi: 10.1080/23723556.2016.1260671. eCollection 2017. Mol Cell Oncol. 2016. PMID: 28197534 Free PMC article.
RNF4, a SUMO-targeted ubiquitin ligase, stabilizes a selected group of oncoproteins. It potentiates oncoprotein activity and serves as a positive feedback agonist of Wnt and Notch pathways. RNF4 is essential for cancer cell survival and its levels are elevate …
RNF4, a SUMO-targeted ubiquitin ligase, stabilizes a selected group of oncoproteins. It potentiates oncoprotein activity and serves a …
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. Krastev DB, et al. Nat Cell Biol. 2022 Jan;24(1):62-73. doi: 10.1038/s41556-021-00807-6. Epub 2022 Jan 10. Nat Cell Biol. 2022. PMID: 35013556 Free PMC article.
Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. ...We found that following trapping, PARP1 is SUMOylated b …
Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping P …
RNF4 Regulates the BLM Helicase in Recovery From Replication Fork Collapse.
Ellis N, Zhu J, Yagle MK, Yang WC, Huang J, Kwako A, Seidman MM, Matunis MJ. Ellis N, et al. Front Genet. 2021 Nov 12;12:753535. doi: 10.3389/fgene.2021.753535. eCollection 2021. Front Genet. 2021. PMID: 34868226 Free PMC article.
Here we demonstrated that RNF4 is required for the restart of DNA replication following prolonged hydroxyurea (HU)-induced replication stress. ...Consistent with it being a functionally important RNF4 substrate, co-depletion of BLM rescued defects in the firing of n …
Here we demonstrated that RNF4 is required for the restart of DNA replication following prolonged hydroxyurea (HU)-induced replicatio …
RNF4 prevents genomic instability caused by chronic DNA under-replication.
Oram MK, Baxley RM, Simon EM, Lin K, Chang YC, Wang L, Myers CL, Bielinsky AK. Oram MK, et al. DNA Repair (Amst). 2024 Mar;135:103646. doi: 10.1016/j.dnarep.2024.103646. Epub 2024 Feb 7. DNA Repair (Amst). 2024. PMID: 38340377 Free article.
Here, we extend these studies to human cells, examining the requirement for the human STUbL RING finger protein 4 (RNF4) in MCM10 mutant cancer cells. We find that MCM10 and RNF4 independently promote origin firing but regulate DNA synthesis epistatically and …
Here, we extend these studies to human cells, examining the requirement for the human STUbL RING finger protein 4 (RNF4) in MCM10 mut …
109 results