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2002 1
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2023 5
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49 results

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Page 1
Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis.
Fu J, Liao L, Balaji KS, Wei C, Kim J, Peng J. Fu J, et al. Oncogene. 2021 Jan;40(3):465-474. doi: 10.1038/s41388-020-01556-w. Epub 2020 Nov 16. Oncogene. 2021. PMID: 33199825 Free PMC article. Review.
In this review, we summarize current knowledge about RNF40 gene structure and the role of RNF40 in histone H2B monoubiquitylation, DNA damage repair, apoptosis, cancer development, and metastasis. We also underscore challenges in applying this information to …
In this review, we summarize current knowledge about RNF40 gene structure and the role of RNF40 in histone H2B monoubiquitylat …
M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.
Yadav P, Subbarayalu P, Medina D, Nirzhor S, Timilsina S, Rajamanickam S, Eedunuri VK, Gupta Y, Zheng S, Abdelfattah N, Huang Y, Vadlamudi R, Hromas R, Meltzer P, Houghton P, Chen Y, Rao MK. Yadav P, et al. Cancer Res. 2022 May 16;82(10):1872-1889. doi: 10.1158/0008-5472.CAN-21-2106. Cancer Res. 2022. PMID: 35303054 Free PMC article.
RNF40, which is historically known to ubiquitinate H2B, inhibited H2A ubiquitination in cancer by interacting with and affecting the stability of DDB1-CUL4-based ubiquitin E3 ligase complex. Taken together, this study directly links increased activity of ALKBH5 with …
RNF40, which is historically known to ubiquitinate H2B, inhibited H2A ubiquitination in cancer by interacting with and affecti …
RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.
Prokakis E, Jansari S, Boshnakovska A, Wiese M, Kusch K, Kramm C, Dullin C, Rehling P, Glatzel M, Pantel K, Wikman H, Johnsen SA, Gallwas J, Wegwitz F. Prokakis E, et al. Cell Death Dis. 2023 Sep 28;14(9):641. doi: 10.1038/s41419-023-06157-5. Cell Death Dis. 2023. PMID: 37770435 Free PMC article.
Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC lesions and are responsible for the rapid development of chemotherapy resis …
Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due to the lack of targeted therapie …
The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells.
Schneider D, Chua RL, Molitor N, Hamdan FH, Rettenmeier EM, Prokakis E, Mishra VK, Kari V, Wegwitz F, Johnsen SA, Kosinsky RL. Schneider D, et al. Clin Epigenetics. 2019 Jul 2;11(1):98. doi: 10.1186/s13148-019-0698-x. Clin Epigenetics. 2019. PMID: 31266541 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide, and deciphering underlying molecular mechanism is essential. ...Surprisingly, our previous work revealed that the H2B ubiquitin ligase RING finger protein 40 (RNF4 …
BACKGROUND: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide, and deciphering underlying …
Loss of RNF40 Decreases NF-kappaB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
Kosinsky RL, Chua RL, Qui M, Saul D, Mehlich D, Ströbel P, Schildhaus HU, Wegwitz F, Faubion WA, Johnsen SA. Kosinsky RL, et al. J Crohns Colitis. 2019 Mar 26;13(3):362-373. doi: 10.1093/ecco-jcc/jjy165. J Crohns Colitis. 2019. PMID: 30321325 Free PMC article.
Here, we examined the effect of RNF40 loss on CRC cells in vitro and on inflammation and inflammatory signaling in vitro and in vivo. METHODS: We evaluated H2Bub1 levels in human and murine colorectal tumors by immunohistochemistry. Moreover, we correlated H2Bub1 and RN …
Here, we examined the effect of RNF40 loss on CRC cells in vitro and on inflammation and inflammatory signaling in vitro and in vivo. …
The roles of the tumor suppressor parafibromin in cancer.
Zheng HC, Xue H, Zhang CY. Zheng HC, et al. Front Cell Dev Biol. 2022 Sep 21;10:1006400. doi: 10.3389/fcell.2022.1006400. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36211470 Free PMC article. Review.
Parafibromin transcriptionally increases the expression of c-Myc, decreases CPEB1 expression by interacting with H3M4, and reduces cyclin D1 expression by binding to H3K9. The RNF20/RNF40/parafibromin complex induces monoubiquitination of H2B-K120, and SHP2-mediated dephos …
Parafibromin transcriptionally increases the expression of c-Myc, decreases CPEB1 expression by interacting with H3M4, and reduces cyclin D1 …
RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk.
Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA, Tuckermann J. Najafova Z, et al. Cell Death Differ. 2021 Feb;28(2):700-714. doi: 10.1038/s41418-020-00614-w. Epub 2020 Sep 8. Cell Death Differ. 2021. PMID: 32901120 Free PMC article.
Our previous work indicated a role of the histone 2B ubiquitin ligase RNF40 in controlling osteoblast differentiation in vitro. Here, we demonstrate that RNF40 has a stage-dependent function in controlling osteoblast differentiation in vivo. RNF40 expression …
Our previous work indicated a role of the histone 2B ubiquitin ligase RNF40 in controlling osteoblast differentiation in vitro. Here, …
Role of H2B mono-ubiquitination in the initiation and progression of cancer.
Zhou S, Cai Y, Liu X, Jin L, Wang X, Ma W, Zhang T. Zhou S, et al. Bull Cancer. 2021 Apr;108(4):385-398. doi: 10.1016/j.bulcan.2020.12.007. Epub 2021 Mar 6. Bull Cancer. 2021. PMID: 33685627 Review.
RNF20/40 is often altered in the primary tumors including colorectal cancer, breast cancer, ovarian cancer, prostate cancer, and lung cancer, and the loss of H2Bub1 is usually associated with poor prognosis in tumor patients. ...This review also …
RNF20/40 is often altered in the primary tumors including colorectal cancer, breast cancer, ovarian cancer, prostate …
Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
Deng Z, Ai H, Sun M, Tong Z, Du Y, Qu Q, Zhang L, Xu Z, Tao S, Shi Q, Li JB, Pan M, Liu L. Deng Z, et al. Mol Cell. 2023 Sep 7;83(17):3080-3094.e14. doi: 10.1016/j.molcel.2023.08.001. Epub 2023 Aug 25. Mol Cell. 2023. PMID: 37633270
Our structures show that Bre1 and RNF40 directly bind nucleosomal DNA, exhibiting a conserved E3/E2/nucleosome interaction pattern from yeast to humans for H2B monoubiquitylation. ...Our study provides mechanistic insights into the site-specific monoubiquitylation of H2B, …
Our structures show that Bre1 and RNF40 directly bind nucleosomal DNA, exhibiting a conserved E3/E2/nucleosome interaction pattern fr …
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Ferrari AJ, Rawat P, Rendulich HS, Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, Scharpf RB, Mitchell MA, Tanyi JL, Morgan MA, Schwartz LE, Soong TR, Velculescu VE, Drapkin R. Ferrari AJ, et al. JCI Insight. 2023 Jun 22;8(12):e164995. doi: 10.1172/jci.insight.164995. JCI Insight. 2023. PMID: 37345659 Free PMC article.
To examine whether dysregulation of a specific E3 ligase contributes to the loss of H2Bub1, we explored expression of ring finger protein 40 (RNF40), ARID1A, and UBR7 in the same case cohort. Loss of RNF40 was significantly and profoundly correlated with loss of H2B …
To examine whether dysregulation of a specific E3 ligase contributes to the loss of H2Bub1, we explored expression of ring finger protein 40 …
49 results