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Page 1
RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis.
Yin Q, Li Y, Zhou Z, Li X, Li M, Liu C, Dong D, Wang G, Zhu M, Yang J, Jin Y, Guo L, Yin Y. Yin Q, et al. Cell Rep. 2022 Jul 12;40(2):111071. doi: 10.1016/j.celrep.2022.111071. Cell Rep. 2022. PMID: 35830798 Free article.
Liver-specific deletion of Rpa1 results in downregulation of genes related to fatty acid oxidation and impaired fatty acid oxidation, which leads to hepatic steatosis and hepatocellular carcinoma. Mechanistically, RPA1 binds gene regulatory regions, chromatin …
Liver-specific deletion of Rpa1 results in downregulation of genes related to fatty acid oxidation and impaired fatty acid oxidation, …
RPA1 expression in esophageal carcinoma and its influence on radiosensitivity of esophageal carcinoma TE-1 cells.
Zhang DJ, Xiang J, Wang X, Wang J, Xiao JC, Xu W, Xu H, Xin Y, Zhang LZ, Pei DS, Zheng JN, Gu YM. Zhang DJ, et al. Panminerva Med. 2015 Dec;57(4):183-9. Panminerva Med. 2015. PMID: 26824734
AIM: To determinate the RPA1 expression in esophageal carcinoma and the paired tumor-adjacent tissue, and to explore the influence of RPA1 on radiosensitivity of esophageal carcinoma TE-1 cells. ...CONCLUSION: The over-expression of RPA1 in esop …
AIM: To determinate the RPA1 expression in esophageal carcinoma and the paired tumor-adjacent tissue, and to explore the influ …
Dyskeratosis Congenita and Related Telomere Biology Disorders.
Savage SA, Niewisch MR. Savage SA, et al. 2009 Nov 12 [updated 2023 Jan 19]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2009 Nov 12 [updated 2023 Jan 19]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301779 Free Books & Documents. Review.
People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. ...GENETIC COUNSELING: …
People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, …
[Effects of RPA1 down-regulation on the invasion and migration and cell cycle of human nasopharyngeal carcinoma CNE-2R cells with radio resistance].
Zhang ZX, Lu HY, Yang ZH, Liu CH, Zhan WH, Zhe H, Zhao R. Zhang ZX, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021 Sep;37(5):490-494. doi: 10.12047/j.cjap.6092.2021.042. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021. PMID: 34816659 Free article. Chinese.
Objective: To investigate the effects of RPA1 silencing on the invasion, migration and cell cycle of human nasopharyngeal carcinoma CNE-2R cells. ...Conclusion: After RPA1 silenced, the proliferation and migration of radio resistant human nasopharyngeal ca …
Objective: To investigate the effects of RPA1 silencing on the invasion, migration and cell cycle of human nasopharyngeal carcinom …
Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway.
Wang J, Yang T, Chen H, Li H, Zheng S. Wang J, et al. Biochem Biophys Res Commun. 2018 Apr 6;498(3):424-430. doi: 10.1016/j.bbrc.2018.02.167. Epub 2018 Mar 15. Biochem Biophys Res Commun. 2018. PMID: 29477843
Human replication protein A (RPA), a three-subunit protein, plays a central role in eukaryotic DNA replication, homologous recombination, and excision repair, including RPA1, RPA2 and RPA3. Recently, some studies focusing on the relation between RPA1 and carcinogene …
Human replication protein A (RPA), a three-subunit protein, plays a central role in eukaryotic DNA replication, homologous recombination, an …
Replication Protein A (RPA1, RPA2 and RPA3) expression in gastric cancer: correlation with clinicopathologic parameters and patients' survival.
Fourtziala E, Givalos N, Alexakis N, Griniatsos J, Alevizopoulos N, Kavantzas N, C Lazaris A, Korkolopoulou P, Gakiopoulou H. Fourtziala E, et al. J BUON. 2020 May-Jun;25(3):1482-1489. J BUON. 2020. PMID: 32862594 Free article.
PURPOSE: Replication Protein A (RPA) consists of three subunits (RPA1, RPA2 and RPA3) essential for all major DNA metabolic pathways. ...RESULTS: All the three subunits showed widespread nuclear expressions in gastric carcinomas with significant associations among t …
PURPOSE: Replication Protein A (RPA) consists of three subunits (RPA1, RPA2 and RPA3) essential for all major DNA metabolic pathways. …
Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma.
Feng Y, Jiang Y, Liu J, Liu J, Shi M, Chen J, Zhang J, Tian Y, Yang X, Liu H. Feng Y, et al. J Transl Med. 2023 Oct 19;21(1):738. doi: 10.1186/s12967-023-04574-w. J Transl Med. 2023. PMID: 37858134 Free PMC article.
BACKGROUND: Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. ...
BACKGROUND: Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, …
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.
Zhang Z, Huo H, Liao K, Wang Z, Gong Z, Li Y, Liu C, Hu G. Zhang Z, et al. Exp Cell Res. 2018 Oct 15;371(2):330-341. doi: 10.1016/j.yexcr.2018.08.025. Epub 2018 Aug 23. Exp Cell Res. 2018. PMID: 30144445
Studies on the relationship between RPA1 and the radiosensitivity of NPC are substantially limited. It was hypothesized that RPA1 plays a crucial role in predicting the radiosensitivity of NPC. ...The silencing of RPA1 enhanced the radiosensitivity of CNE-2R …
Studies on the relationship between RPA1 and the radiosensitivity of NPC are substantially limited. It was hypothesized that RPA1 …
A relationship between replication protein A and occurrence and prognosis of esophageal carcinoma.
Dahai Y, Sanyuan S, Hong L, Di Z, Chong Z. Dahai Y, et al. Cell Biochem Biophys. 2013 Sep;67(1):175-80. doi: 10.1007/s12013-013-9530-y. Cell Biochem Biophys. 2013. PMID: 23420526
Esophageal carcinoma (EC) is an aggressive and the third most common cancer of the digestive tract with poor prognosis. ...In conclusion, RPA1 could be a useful prognostic indicator in patients with esophageal carcinoma and might be a future attractive therap …
Esophageal carcinoma (EC) is an aggressive and the third most common cancer of the digestive tract with poor prognosis. ...In conclus …
Polymorphisms within base and nucleotide excision repair pathways and risk of differentiated thyroid carcinoma.
Cipollini M, Figlioli G, Maccari G, Garritano S, De Santi C, Melaiu O, Barone E, Bambi F, Ermini S, Pellegrini G, Cristaudo A, Foddis R, Bonotti A, Romei C, Vivaldi A, Agate L, Molinari E, Barale R, Forsti A, Hemminki K, Elisei R, Gemignani F, Landi S. Cipollini M, et al. DNA Repair (Amst). 2016 May;41:27-31. doi: 10.1016/j.dnarep.2016.03.011. Epub 2016 Mar 31. DNA Repair (Amst). 2016. PMID: 27062014
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, r …
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at …
50 results