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Year Number of Results
1993 8
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1995 27
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2000 58
2001 53
2002 63
2003 65
2004 90
2005 91
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2007 113
2008 110
2009 120
2010 131
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3,795 results

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Page 1
RUNX1 and cancer.
Lin TC. Lin TC. Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188715. doi: 10.1016/j.bbcan.2022.188715. Epub 2022 Mar 7. Biochim Biophys Acta Rev Cancer. 2022. PMID: 35271994 Free article. Review.
However, emerging and discoverable RUNX1 somatic mutations, RUNX1 expressional signatures in normal tissues and cancers, and RUNX1's clinical significance in many cancer types have attracted attention for considering RUNX1 as a biomarker …
However, emerging and discoverable RUNX1 somatic mutations, RUNX1 expressional signatures in normal tissues and cancers …
RUNX1 as a Novel Molecular Target for Breast Cancer.
Ariffin NS. Ariffin NS. Clin Breast Cancer. 2022 Aug;22(6):499-506. doi: 10.1016/j.clbc.2022.04.006. Epub 2022 Apr 26. Clin Breast Cancer. 2022. PMID: 35599145 Review.
Increasing number of evidence also shows the involvement of RUNX1 in breast cancer migration and invasion that may lead to breast cancer metastasis. ...The association of RUNX1 with other types of cancer is also included to emphasize a wider and …
Increasing number of evidence also shows the involvement of RUNX1 in breast cancer migration and invasion that may lead to bre …
RUNX1 Dosage in Development and Cancer.
Lie-A-Ling M, Mevel R, Patel R, Blyth K, Baena E, Kouskoff V, Lacaud G. Lie-A-Ling M, et al. Mol Cells. 2020 Feb 29;43(2):126-138. doi: 10.14348/molcells.2019.0301. Mol Cells. 2020. PMID: 31991535 Free PMC article. Review.
It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RU …
It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hemat …
An expanded universe of cancer targets.
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. Hahn WC, et al. Cell. 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020. Cell. 2021. PMID: 33667368 Free PMC article. Review.
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains my …
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understandi …
RUNX1-dependent mechanisms in biological control and dysregulation in cancer.
Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. Hong D, et al. J Cell Physiol. 2019 Jun;234(6):8597-8609. doi: 10.1002/jcp.27841. Epub 2018 Dec 4. J Cell Physiol. 2019. PMID: 30515788 Free PMC article. Review.
Compromised RUNX1 regulation is associated with many cancers. In this review, we highlight evidence for RUNX1 control in both invertebrate and mammalian development and recent novel findings of perturbed RUNX1 control in breast cancer that has i …
Compromised RUNX1 regulation is associated with many cancers. In this review, we highlight evidence for RUNX1 control i …
Role of RUNX1 in hematological malignancies.
Sood R, Kamikubo Y, Liu P. Sood R, et al. Blood. 2017 Apr 13;129(15):2070-2082. doi: 10.1182/blood-2016-10-687830. Epub 2017 Feb 8. Blood. 2017. PMID: 28179279 Free PMC article. Review.
RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. ...
RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cau …
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.
Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X, Huang B. Zhou L, et al. Nat Immunol. 2023 Dec;24(12):2042-2052. doi: 10.1038/s41590-023-01662-3. Epub 2023 Nov 2. Nat Immunol. 2023. PMID: 37919525 Free PMC article.
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic-erythroid progenitor cell (MEP) di …
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors h …
Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer.
Becker WR, Nevins SA, Chen DC, Chiu R, Horning AM, Guha TK, Laquindanum R, Mills M, Chaib H, Ladabaum U, Longacre T, Shen J, Esplin ED, Kundaje A, Ford JM, Curtis C, Snyder MP, Greenleaf WJ. Becker WR, et al. Nat Genet. 2022 Jul;54(7):985-995. doi: 10.1038/s41588-022-01088-x. Epub 2022 Jun 20. Nat Genet. 2022. PMID: 35726067 Free PMC article.
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,000 to 10,000 cells p …
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorecta …
RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.
Ma H, Jiang S, Yuan Y, Li J, Li Y, Lv Y, Du T, Guan J, Jiang X, Tian L, Zheng Q, Yang L, Li Q. Ma H, et al. FASEB J. 2023 Nov;37(11):e23195. doi: 10.1096/fj.202300687RR. FASEB J. 2023. PMID: 37801076
It also functions in the occurrence and development of tumors. However, the role and mechanism of action of RUNX1 in non-small cell lung cancer (NSCLC) are not yet clear. We used a bioinformatics approach as well as in vitro and in vivo assays to evaluate the role o …
It also functions in the occurrence and development of tumors. However, the role and mechanism of action of RUNX1 in non-small cell l …
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Chen Y, He Z, Yang S, Chen C, Xiong W, He Y, Liu S. Chen Y, et al. J Transl Med. 2023 Dec 6;21(1):886. doi: 10.1186/s12967-023-04762-8. J Transl Med. 2023. PMID: 38057816 Free PMC article.
RUNX1 knockdown inhibits the physiological function of ovarian cancer cells and regulates apoptosis through the FOXO1-Bcl2 axis. ...In addition, RUNX1 knockdown can significantly increase the sensitivity to clinical drug therapy for ovarian cancer. ...
RUNX1 knockdown inhibits the physiological function of ovarian cancer cells and regulates apoptosis through the FOXO1-Bcl2 axi …
3,795 results