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The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T. Takahama M, et al. Cell Rep. 2017 Sep 19;20(12):2944-2954. doi: 10.1016/j.celrep.2017.08.085. Cell Rep. 2017. PMID: 28930687 Free PMC article.
RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B deficiency enhances replication of vaccinia virus, a DNA virus. ...
RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B deficiency enhances replicatio …
miR-448 targets Rab2B and is pivotal in the suppression of pancreatic cancer.
Jin J, Wu Y, Zhou D, Sun Q, Wang W. Jin J, et al. Oncol Rep. 2018 Sep;40(3):1379-1389. doi: 10.3892/or.2018.6562. Epub 2018 Jul 12. Oncol Rep. 2018. PMID: 30015954 Free PMC article.
The results revealed a negative correlation between miR-448 and Rab2B in the pancreatic tissues and cell lines. The results of bioinformatics analysis indicated that miR-448 directly targeted Rab2B. ...The results suggested that miR-448 was a negative regulator of …
The results revealed a negative correlation between miR-448 and Rab2B in the pancreatic tissues and cell lines. The results of bioinf …
FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
Morohoshi A, Miyata H, Oyama Y, Oura S, Noda T, Ikawa M. Morohoshi A, et al. Development. 2021 Nov 1;148(21):dev199644. doi: 10.1242/dev.199644. Epub 2021 Oct 29. Development. 2021. PMID: 34714330 Free PMC article.
Family with sequence similarity 71, member F1 and F2 (FAM71F1 and FAM71F2) are testis-enriched proteins that contain a RAB2B-binding domain, a small GTPase involved in vesicle transport and membrane trafficking. ...Mass spectrometry analysis after immunoprecipitation indic …
Family with sequence similarity 71, member F1 and F2 (FAM71F1 and FAM71F2) are testis-enriched proteins that contain a RAB2B-binding …
METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
Hu Y, Li Y, Huang Y, Jin Z, Wang C, Wang H, Xu J. Hu Y, et al. Eur J Pharmacol. 2020 Jul 15;879:173134. doi: 10.1016/j.ejphar.2020.173134. Epub 2020 Apr 24. Eur J Pharmacol. 2020. PMID: 32339511
The expression of METTL3 was significantly correlated with the expression of RAB2B, one member of RAS oncogene family. Over expression of RAB2B can significantly attenuate sh-METTL3-suppressed cell proliferation. Mechanistically, METTL3 can increase the mRNA stabili …
The expression of METTL3 was significantly correlated with the expression of RAB2B, one member of RAS oncogene family. Over expressio …
MicroRNA-425 induces apoptosis and suppresses migration and invasion of human cervical cancer cells by targeting RAB2B.
Tian Y, Luo Y, Wang J. Tian Y, et al. Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211016131. doi: 10.1177/20587384211016131. Int J Immunopathol Pharmacol. 2021. PMID: 34024178 Free PMC article.

Additionally, miR-425 could inhibit the growth of xenografted tumors in vivo. In silico analysis and dual luciferase assay revealed RAB2B as the direct target of miR-425 in cervical cancer. RAB2B was found to be significantly (P < 0.05) up-regulated in cervical c

…
Additionally, miR-425 could inhibit the growth of xenografted tumors in vivo. In silico analysis and dual luciferase assay revealed RAB2B …
Hesperetin Ameliorates Inhibition of Neuronal and Oligodendroglial Cell Differentiation Phenotypes Induced by Knockdown of Rab2b, an Autism Spectrum Disorder-Associated Gene Product.
Kato Y, Shirai R, Ohbuchi K, Oizumi H, Yamamoto M, Miyata W, Iguchi T, Mimaki Y, Miyamoto Y, Yamauchi J. Kato Y, et al. Neurol Int. 2023 Mar 10;15(1):371-391. doi: 10.3390/neurolint15010025. Neurol Int. 2023. PMID: 36976668 Free PMC article.
ASD is thought to be a multifactorial disorder with a range of genetic and environmental factors/candidates. Among such factors is the rab2b gene, although it remains unclear how Rab2b itself is related to the CNS neuronal and glial developmental disorganization obs …
ASD is thought to be a multifactorial disorder with a range of genetic and environmental factors/candidates. Among such factors is the ra …
Rab2 stimulates LC3 lipidation on secretory membranes by noncanonical autophagy.
J Tisdale E, R Artalejo C. J Tisdale E, et al. Exp Cell Res. 2023 Aug 1;429(1):113635. doi: 10.1016/j.yexcr.2023.113635. Epub 2023 May 16. Exp Cell Res. 2023. PMID: 37201743
To learn how Rab2 'gain of function' influences the structure/activity of membrane compartments in the early secretory pathway that may contribute to oncogenesis, NRK cells were transfected with Rab2B cDNA. We found that Rab2B overexpression had a dramatic effect on …
To learn how Rab2 'gain of function' influences the structure/activity of membrane compartments in the early secretory pathway that may cont …
Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.
Aizawa M, Fukuda M. Aizawa M, et al. J Biol Chem. 2015 Sep 4;290(36):22250-61. doi: 10.1074/jbc.M115.669242. Epub 2015 Jul 24. J Biol Chem. 2015. PMID: 26209634 Free PMC article.
Rab2A, which is highly homologous to Rab2B, indicating that these Rab isoforms non-redundantly regulate Golgi morphology possibly through interaction with isoform-specific effector molecules. In addition, we identified Golgi-associated Rab2B interactor-like 4 (GARI- …
Rab2A, which is highly homologous to Rab2B, indicating that these Rab isoforms non-redundantly regulate Golgi morphology possibly thr …
Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.
Ni X, Ma Y, Cheng H, Jiang M, Guo L, Ji C, Gu S, Cao Y, Xie Y, Mao Y. Ni X, et al. J Hum Genet. 2002;47(10):548-51. doi: 10.1007/s100380200083. J Hum Genet. 2002. PMID: 12376746
The small GTPase Rab2 is a resident of pre-Golgi intermediates and is required for protein transport from the endoplasmic reticulum to the Golgi complex. We identified a novel human Rab (Rab2B) gene that was 2312 bp in length and encoded a protein of 216 amino acid residue …
The small GTPase Rab2 is a resident of pre-Golgi intermediates and is required for protein transport from the endoplasmic reticulum to the G …
A plasmid library of full-length zebrafish rab proteins for in vivo cell biology.
Hall TE, Martel N, Lo HP, Xiong Z, Parton RG. Hall TE, et al. Cell Logist. 2017 Mar 1;7(1):e1301151. doi: 10.1080/21592799.2017.1301151. eCollection 2017. Cell Logist. 2017. PMID: 28396820 Free PMC article. Review.
In contrast, we were unable to identify zebrafish orthologues of the mammalian Rab2b, Rab17 or Rab29. We make this resource available through the Addgene repository to facilitate cell biologic approaches using this model....
In contrast, we were unable to identify zebrafish orthologues of the mammalian Rab2b, Rab17 or Rab29. We make this resource available …
24 results