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114 results

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RAB31 marks and controls an ESCRT-independent exosome pathway.
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T. Wei D, et al. Cell Res. 2021 Feb;31(2):157-177. doi: 10.1038/s41422-020-00409-1. Epub 2020 Sep 21. Cell Res. 2021. PMID: 32958903 Free PMC article.
Active RAB31 interacts with the SPFH domain and drives ILV formation via the Flotillin domain of flotillin proteins. Meanwhile, RAB31 recruits GTPase-activating protein TBC1D2B to inactivate RAB7, thereby preventing the fusion of MVEs with lysosomes and enabling the …
Active RAB31 interacts with the SPFH domain and drives ILV formation via the Flotillin domain of flotillin proteins. Meanwhile, RA …
Rab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT.
Chen K, Xu J, Tong YL, Yan JF, Pan Y, Wang WJ, Zheng L, Zheng XX, Hu C, Hu X, Shen X, Chen W. Chen K, et al. Cell Death Dis. 2023 Feb 13;14(2):115. doi: 10.1038/s41419-023-05596-4. Cell Death Dis. 2023. PMID: 36781842 Free PMC article.
Reduced Rab31 expression induces tumor cell apoptosis and increases cisplatin sensitivity in STAD cells; Rab31 overexpression yielded the opposite result. Rab31 silencing prevented STAD cell migration, whereas the overexpression of Rab31 increased the …
Reduced Rab31 expression induces tumor cell apoptosis and increases cisplatin sensitivity in STAD cells; Rab31 overexpression …
Rab31-dependent regulation of transforming growth factor ss expression in breast cancer cells.
Soelch S, Beaufort N, Loessner D, Kotzsch M, Reuning U, Luther T, Kirchner T, Magdolen V. Soelch S, et al. Mol Med. 2021 Dec 14;27(1):158. doi: 10.1186/s10020-021-00419-8. Mol Med. 2021. PMID: 34906074 Free PMC article.
As an underlying mechanism, Rab31 is presumed to act as a molecular switch between a more proliferative and an invasive phenotype. This prompted us to analyze whether Rab31 overexpression in breast cancer cells affects expression of genes involved in epithelial-to-m …
As an underlying mechanism, Rab31 is presumed to act as a molecular switch between a more proliferative and an invasive phenotype. Th …
Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation.
Huang Y, Liu R, Han X, Hou X, Tian Y, Zhang W. Huang Y, et al. Int J Biol Sci. 2022 Jan 1;18(1):112-123. doi: 10.7150/ijbs.63388. eCollection 2022. Int J Biol Sci. 2022. PMID: 34975321 Free PMC article.
Rab31 knockdown inhibited while Rab31 overexpression promoted the migration and invasion capabilities of cervical cancer cells. ...More importantly, Rab31 knockdown promoted and Rab31 overexpression inhibited MAPK6 degradation. ...
Rab31 knockdown inhibited while Rab31 overexpression promoted the migration and invasion capabilities of cervical cancer cells …
Rab31 promotes activation of hepatic stellate cells by accelerating TGF-beta receptor II complex endocytosis.
Qiu C, Liu Y, Huang S, Ning B, He S, Zhong L. Qiu C, et al. Int J Biochem Cell Biol. 2022 Mar;144:106170. doi: 10.1016/j.biocel.2022.106170. Epub 2022 Jan 26. Int J Biochem Cell Biol. 2022. PMID: 35091093
However, whether Rab31 is involved in hepatic stellate cells activation is unknown. ...Next, mouse primary hepatic stellate cells were prepared, and their continuous activation was accompanied by Rab31 expression increased. Interestingly, knockdown of Rab31 b …
However, whether Rab31 is involved in hepatic stellate cells activation is unknown. ...Next, mouse primary hepatic stellate cells wer …
RAB31 is targeted by miR-26b and serves a role in the promotion of osteosarcoma.
Wu Q, Feng Q, Xiong Y, Liu X. Wu Q, et al. Oncol Lett. 2020 Nov;20(5):244. doi: 10.3892/ol.2020.12106. Epub 2020 Sep 15. Oncol Lett. 2020. PMID: 32973957 Free PMC article.
However, the function of RAB31 in osteosarcoma (OS) has not been previously studied. The present study identified that the expression levels of RAB31 were significantly higher in OS tissue samples compared with matched adjacent non-tumor tissue samples, and high …
However, the function of RAB31 in osteosarcoma (OS) has not been previously studied. The present study identified that the expression …
The role of the small GTPase Rab31 in cancer.
Chua CE, Tang BL. Chua CE, et al. J Cell Mol Med. 2015 Jan;19(1):1-10. doi: 10.1111/jcmm.12403. Epub 2014 Dec 3. J Cell Mol Med. 2015. PMID: 25472813 Free PMC article. Review.
Elevated Rab31 stabilizes MUC1-C levels in an auto-inductive loop that could lead to aberrant signalling and gene expression associated with cancer progression. ...The multifaceted action and influences of Rab31 in cancer is discussed in the light of its new interac …
Elevated Rab31 stabilizes MUC1-C levels in an auto-inductive loop that could lead to aberrant signalling and gene expression associat …
Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency.
Jalagadugula G, Mao G, Goldfinger LE, Wurtzel J, Del Carpio-Cano F, Lambert MP, Estevez B, French DL, Poncz M, Rao AK. Jalagadugula G, et al. Blood Adv. 2022 Sep 13;6(17):5100-5112. doi: 10.1182/bloodadvances.2021006945. Blood Adv. 2022. PMID: 35839075 Free PMC article.
Platelet RAB31 messenger RNA was decreased in the index patient and in 2 additional patients with RHD. ...Downregulation of RUNX1 or RAB31 (by small interfering RNA or CRISPR/Cas9) showed a striking enlargement of EEs, partially reversed by RAB31 reconstituti …
Platelet RAB31 messenger RNA was decreased in the index patient and in 2 additional patients with RHD. ...Downregulation of RUNX1 or …
Overexpression of RAB31 in gastric cancer is associated with released exosomes and increased tumor cell invasion and metastasis.
Wu S, Tang C, Zhang QW, Zhuang Q, Ye X, Xia J, Shi Y, Ning M, Dong ZX, Wan XJ. Wu S, et al. Cancer Med. 2023 Jun;12(12):13497-13510. doi: 10.1002/cam4.6007. Epub 2023 May 24. Cancer Med. 2023. PMID: 37222416 Free PMC article.
BACKGROUND: Gastric cancer (GC) is one of most common cancers worldwide. Several studies have suggested that Rab31 functions as a membrane vesicle transport regulator; however, the mechanism by which RAB31 regulates exosome secretion and promotes metastasis remains …
BACKGROUND: Gastric cancer (GC) is one of most common cancers worldwide. Several studies have suggested that Rab31 functions as a mem …
Association between Rab31/rs9965664 polymorphism and immunoglobulin therapy resistance in patients with Kawasaki disease.
Yu H, Lin Y, Xu Y, Chen K, Wang Y, Fu L, Zhou H, Pi L, Che D, Qiu X, Gu X. Yu H, et al. Front Cardiovasc Med. 2022 Oct 18;9:944508. doi: 10.3389/fcvm.2022.944508. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36329997 Free PMC article.
METHODS: Rab31/rs9965664 polymorphism was genotyped in 1,024 Chinese patients with KD through TaqMan assay. ...The possible mechanism is that Rab31 regulates the NLRP3 pathway negatively to inhibit IVIG response....
METHODS: Rab31/rs9965664 polymorphism was genotyped in 1,024 Chinese patients with KD through TaqMan assay. ...The possible mechanism …
114 results