Rajagopal S - Search Results

1

Quantifying ligand bias at seven-transmembrane receptors.

Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Rajagopal S, et al. Mol Pharmacol. 2011 Sep;80(3):367-77. doi: 10.1124/mol.111.072801. Epub 2011 May 24. Mol Pharmacol. 2011. PMID: 21610196 Free PMC article.

2

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.

Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ. Rajagopal S, et al. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):628-32. doi: 10.1073/pnas.0912852107. Epub 2009 Dec 17. Proc Natl Acad Sci U S A. 2010. PMID: 20018651 Free PMC article.

3

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

Rajagopal S, Rajagopal K, Lefkowitz RJ. Rajagopal S, et al. Among authors: rajagopal k. Nat Rev Drug Discov. 2010 May;9(5):373-86. doi: 10.1038/nrd3024. Nat Rev Drug Discov. 2010. PMID: 20431569 Free PMC article. Review.

4

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Xiao K, et al. Among authors: rajagopal s. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15299-304. doi: 10.1073/pnas.1008461107. Epub 2010 Aug 4. Proc Natl Acad Sci U S A. 2010. PMID: 20686112 Free PMC article.

5

Therapeutic potential of β-arrestin- and G protein-biased agonists.

Whalen EJ, Rajagopal S, Lefkowitz RJ. Whalen EJ, et al. Among authors: rajagopal s. Trends Mol Med. 2011 Mar;17(3):126-39. doi: 10.1016/j.molmed.2010.11.004. Epub 2010 Dec 21. Trends Mol Med. 2011. PMID: 21183406 Free PMC article. Review.

6

Multiple ligand-specific conformations of the β2-adrenergic receptor.

Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ. Kahsai AW, et al. Among authors: rajagopal s. Nat Chem Biol. 2011 Aug 21;7(10):692-700. doi: 10.1038/nchembio.634. Nat Chem Biol. 2011. PMID: 21857662 Free PMC article.

7

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. Hara MR, et al. Among authors: rajagopal s. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. Nature. 2011. PMID: 21857681 Free PMC article.

8

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Nobles KN, et al. Among authors: rajagopal s. Sci Signal. 2011 Aug 9;4(185):ra51. doi: 10.1126/scisignal.2001707. Sci Signal. 2011. PMID: 21868357 Free PMC article.

9

C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways.

Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S. Smith JS, et al. Among authors: rajagopal s. Mol Pharmacol. 2017 Aug;92(2):136-150. doi: 10.1124/mol.117.108522. Epub 2017 May 30. Mol Pharmacol. 2017. PMID: 28559424 Free PMC article.

10

Biased signalling: from simple switches to allosteric microprocessors.

Smith JS, Lefkowitz RJ, Rajagopal S. Smith JS, et al. Among authors: rajagopal s. Nat Rev Drug Discov. 2018 Apr;17(4):243-260. doi: 10.1038/nrd.2017.229. Epub 2018 Jan 5. Nat Rev Drug Discov. 2018. PMID: 29302067 Free PMC article. Review.

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