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Selected commensals educate the intestinal vascular and immune system for immunocompetence.
Romero R, Zarzycka A, Preussner M, Fischer F, Hain T, Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U. Romero R, et al. Among authors: rajalingam k. Microbiome. 2022 Sep 28;10(1):158. doi: 10.1186/s40168-022-01353-5. Microbiome. 2022. PMID: 36171625 Free PMC article.
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Visekruna A, et al. Among authors: rajalingam k. J Clin Invest. 2019 Apr 2;129(5):1972-1983. doi: 10.1172/JCI98929. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939122 Free PMC article.
ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.
Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, Werner U, Roth W, Wilken-Schmitz A, Tegeder I, Rajalingam K. Mooz J, et al. Among authors: rajalingam k. Sci Adv. 2022 Mar 18;8(11):eabk1538. doi: 10.1126/sciadv.abk1538. Epub 2022 Mar 18. Sci Adv. 2022. PMID: 35302851 Free PMC article.
ERK3/MAPK6 controls IL-8 production and chemotaxis.
Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K. Bogucka K, et al. Among authors: rajalingam k. Elife. 2020 Apr 21;9:e52511. doi: 10.7554/eLife.52511. Elife. 2020. PMID: 32314963 Free PMC article.
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.
Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T. Ulges A, et al. Among authors: rajalingam k. Nat Immunol. 2015 Mar;16(3):267-75. doi: 10.1038/ni.3083. Epub 2015 Jan 19. Nat Immunol. 2015. PMID: 25599562
Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.
Buehler U, Schulenburg K, Yurugi H, Šolman M, Abankwa D, Ulges A, Tenzer S, Bopp T, Thiede B, Zipp F, Rajalingam K. Buehler U, et al. Among authors: rajalingam k. EMBO J. 2018 Aug 15;37(16):e99429. doi: 10.15252/embj.201899429. Epub 2018 Jul 26. EMBO J. 2018. PMID: 30049713 Free PMC article.
Oncogenic ERBB3 mutations in human cancers.
Jaiswal BS, Kljavin NM, Stawiski EW, Chan E, Parikh C, Durinck S, Chaudhuri S, Pujara K, Guillory J, Edgar KA, Janakiraman V, Scholz RP, Bowman KK, Lorenzo M, Li H, Wu J, Yuan W, Peters BA, Kan Z, Stinson J, Mak M, Modrusan Z, Eigenbrot C, Firestein R, Stern HM, Rajalingam K, Schaefer G, Merchant MA, Sliwkowski MX, de Sauvage FJ, Seshagiri S. Jaiswal BS, et al. Among authors: rajalingam k. Cancer Cell. 2013 May 13;23(5):603-17. doi: 10.1016/j.ccr.2013.04.012. Cancer Cell. 2013. PMID: 23680147 Free article.
Endo-PDI is required for TNFα-induced angiogenesis.
Camargo LL, Babelova A, Mieth A, Weigert A, Mooz J, Rajalingam K, Heide H, Wittig I, Lopes LR, Brandes RP. Camargo LL, et al. Among authors: rajalingam k. Free Radic Biol Med. 2013 Dec;65:1398-1407. doi: 10.1016/j.freeradbiomed.2013.09.028. Epub 2013 Oct 5. Free Radic Biol Med. 2013. PMID: 24103565
123 results