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1994 1
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2003 5
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177 results

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Page 1
RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases.
Audia S, Brescia C, Dattilo V, D'Antona L, Calvano P, Iuliano R, Trapasso F, Perrotti N, Amato R. Audia S, et al. Cancers (Basel). 2023 Jan 12;15(2):486. doi: 10.3390/cancers15020486. Cancers (Basel). 2023. PMID: 36672435 Free PMC article. Review.
RANBP1 encoded by RANBP1 or HTF9A (Hpall Tiny Fragments Locus 9A), plays regulatory functions of the RAN-network, belonging to the RAS superfamily of small GTPases. ...RANBP1 also appears to be implicated in chemo-hormone and radio-resistance. ...
RANBP1 encoded by RANBP1 or HTF9A (Hpall Tiny Fragments Locus 9A), plays regulatory functions of the RAN-network, belonging to …
RANBP1 promotes colorectal cancer progression by regulating pre-miRNA nuclear export via a positive feedback loop with YAP.
Zheng D, Cao M, Zuo S, Xia X, Zhi C, Lin Y, Deng S, Yuan X. Zheng D, et al. Oncogene. 2022 Feb;41(7):930-942. doi: 10.1038/s41388-021-02036-5. Epub 2021 Oct 6. Oncogene. 2022. PMID: 34615998
In the present study, we observed high expression of RAN binding protein 1 (RANBP1) in CRC tissues. Upregulated RANBP1 expression was strongly associated with TNM stages and was an independent risk factor for poor prognosis. ...Our results revealed the biological ro …
In the present study, we observed high expression of RAN binding protein 1 (RANBP1) in CRC tissues. Upregulated RANBP1 express …
RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma.
Kahm YJ, Kim IG, Kim RK. Kahm YJ, et al. Int J Mol Sci. 2023 Apr 6;24(7):6855. doi: 10.3390/ijms24076855. Int J Mol Sci. 2023. PMID: 37047826 Free PMC article.
CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial-mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and …
CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated ep …
Ranbp1 modulates morphogenesis of the craniofacial midline in mouse models of 22q11.2 deletion syndrome.
Paronett EM, Bryan CA, Maynard ME, Goroff JA, Meechan DW, LaMantia AS, Maynard TM. Paronett EM, et al. Hum Mol Genet. 2023 Jun 5;32(12):1959-1974. doi: 10.1093/hmg/ddad030. Hum Mol Genet. 2023. PMID: 36790128 Free PMC article.
Ranbp1-/- embryos have variably penetrant facial phenotypes, including altered facial morphology and cleft palate. ...Apparently, Ranbp1 is a modulator of craniofacial development, and in the context of broader 22q11 deletion, Ranbp1 mutant phenotypes mirror …
Ranbp1-/- embryos have variably penetrant facial phenotypes, including altered facial morphology and cleft palate. ...Apparently, …
Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals.
Li Y, Zhou J, Min S, Zhang Y, Zhang Y, Zhou Q, Shen X, Jia D, Han J, Sun Q. Li Y, et al. Elife. 2019 Apr 25;8:e41331. doi: 10.7554/eLife.41331. Elife. 2019. PMID: 31021318 Free PMC article.
Much of what we know about RanBP1 is learned from fungi. Intrigued by the long-standing paradox of harboring an extra NES in animal RanBP1, we discovered utterly unexpected cargo dissociation and nuclear export mechanisms for animal RanBP1. In contrast to CRM …
Much of what we know about RanBP1 is learned from fungi. Intrigued by the long-standing paradox of harboring an extra NES in animal …
RanBP1 plays an essential role in directed migration of neural crest cells during development.
Barriga EH, Alasaadi DN, Mencarelli C, Mayor R, Pichaud F. Barriga EH, et al. Dev Biol. 2022 Dec;492:79-86. doi: 10.1016/j.ydbio.2022.09.010. Epub 2022 Oct 4. Dev Biol. 2022. PMID: 36206829 Free article.
Our results indicate that RanBP1 is required for establishing front-to-rear polarity, so that NCs are able to chemotax. Moreover, our work suggests that RanBP1 function in chemotaxis involves the polarity kinase LKB1/PAR4. ...
Our results indicate that RanBP1 is required for establishing front-to-rear polarity, so that NCs are able to chemotax. Moreover, our …
RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17(+) pathological differentiation.
Brescia C, Dattilo V, D'Antona L, Chiarella E, Tallerico R, Audia S, Rocca V, Iuliano R, Trapasso F, Perrotti N, Amato R. Brescia C, et al. Front Immunol. 2023 Jun 27;14:1213805. doi: 10.3389/fimmu.2023.1213805. eCollection 2023. Front Immunol. 2023. PMID: 37441077 Free PMC article.
Our previous work has shown that some of the SGK1-key functions are dependent on RAN-binding protein 1 (RANBP1), a terminal gene in the nuclear transport regulation. Here, we show that RANBP1, similarly to SGK1, is modulated during Th17(+) differentiation and that …
Our previous work has shown that some of the SGK1-key functions are dependent on RAN-binding protein 1 (RANBP1), a terminal gene in t …
RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
Yau KC, Arnaoutov A, Aksenova V, Kaufhold R, Chen S, Dasso M. Yau KC, et al. Cell Cycle. 2020 Aug;19(15):1899-1916. doi: 10.1080/15384101.2020.1782036. Epub 2020 Jun 28. Cell Cycle. 2020. PMID: 32594833 Free PMC article.
Here, we show that RanBP1 controls mitotic RCC1 dynamics in human somatic tissue culture cells. In addition, we observed the re-localization of HURP in metaphase cells after RanBP1 degradation, consistent with the idea that altered RCC1 dynamics functionally modulat …
Here, we show that RanBP1 controls mitotic RCC1 dynamics in human somatic tissue culture cells. In addition, we observed the re-local …
CD147 supports paclitaxel resistance via interacting with RanBP1.
Nan G, Zhao SH, Wang T, Chao D, Tian RF, Wang WJ, Fu X, Lin P, Guo T, Wang B, Sun XX, Chen X, Chen ZN, Wang SJ, Cui HY. Nan G, et al. Oncogene. 2022 Feb;41(7):983-996. doi: 10.1038/s41388-021-02143-3. Epub 2022 Jan 1. Oncogene. 2022. PMID: 34974521 Free PMC article.
Via screening the interacting proteins of CD147(ICD), Ran binding protein 1 (RanBP1) was identified to interact with CD147(ICD) via its C-terminal tail. Furthermore, we showed that RanBP1 mediated CD147-regulated microtubule stability and dynamics as well as respons …
Via screening the interacting proteins of CD147(ICD), Ran binding protein 1 (RanBP1) was identified to interact with CD147(ICD) via i …
RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.
Rensen WM, Roscioli E, Tedeschi A, Mangiacasale R, Ciciarello M, Di Gioia SA, Lavia P. Rensen WM, et al. Oncogene. 2009 Apr 16;28(15):1748-58. doi: 10.1038/onc.2009.24. Epub 2009 Mar 9. Oncogene. 2009. PMID: 19270727
Furthermore, RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent. These results indicate that RanBP1 can modulate the outcome of MT-tar …
Furthermore, RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high …
177 results