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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 10
1991 13
1992 12
1993 9
1994 12
1995 13
1996 17
1997 11
1998 10
1999 16
2000 14
2001 16
2002 13
2003 11
2004 12
2005 10
2006 17
2007 17
2008 23
2009 18
2010 20
2011 16
2012 20
2013 24
2014 14
2015 25
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2018 31
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2020 32
2021 29
2022 22
2023 25
2024 9

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567 results

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Page 1
Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia.
Wang Y, Spolitu S, Zadroga JA, Sarecha AK, Ozcan L. Wang Y, et al. Cell Rep. 2022 Aug 23;40(8):111259. doi: 10.1016/j.celrep.2022.111259. Cell Rep. 2022. PMID: 36001955 Free PMC article.
Rap1a activation is suppressed in obese mouse liver, and restoring its activity improves glucose intolerance. As Rap1a's membrane localization and activation depends on its geranylgeranylation, which is inhibited by statins, we show that statin-treated hepatocytes a …
Rap1a activation is suppressed in obese mouse liver, and restoring its activity improves glucose intolerance. As Rap1a's membr …
Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.
Wu H, Li Z, Yang Y, Zhang L, Yuan Y, Wang Y, Li G, Yang X. Wu H, et al. Cell Signal. 2023 Jun;106:110627. doi: 10.1016/j.cellsig.2023.110627. Epub 2023 Feb 14. Cell Signal. 2023. PMID: 36791985
In the present study, we demonstrated that Hcy upregulates Rap1A expression and knockdown of Rap1A inhibited pro-inflammatory cytokines IL-6 and TNF-alpha levels in ANA-1 cells. ...These data indicate that Rap1A is a novel and important regulator in Hcy-induc …
In the present study, we demonstrated that Hcy upregulates Rap1A expression and knockdown of Rap1A inhibited pro-inflammatory …
Rap1A, Rap1B, and beta-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol.
Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM. Johnson AK, et al. Yale J Biol Med. 2022 Mar 31;95(1):45-56. eCollection 2022 Mar. Yale J Biol Med. 2022. PMID: 35370486 Free PMC article. Clinical Trial.
Rap1A expression significantly correlated with Rap1B expression. ...There were no significant associations between neutrophil engraftment and Rap1A or Rap1B expression. Post hoc exploratory analyses did not reveal an association between social health variables and …
Rap1A expression significantly correlated with Rap1B expression. ...There were no significant associations between neutrophil engraft …
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Li Q, Xu A, Chu Y, Chen T, Li H, Yao L, Zhou P, Xu M. Li Q, et al. Oncol Rep. 2019 Nov;42(5):1815-1824. doi: 10.3892/or.2019.7309. Epub 2019 Sep 12. Oncol Rep. 2019. PMID: 31545475 Free PMC article.
In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. ...Furthermore, Rap1A promoted epithelial-to-mesenchymal transition, possibly through the AKT signaling pathway. ...
In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. ...Furth …
Elevated RAP1A expression correlates with the severity of acute GVHD after umbilical cord blood transplantation.
Wang S, Wang D, Chang Y, Geng L, Qiang P, Sun G, Tang B, Zhao X, Zhou Z, Liu H. Wang S, et al. Transpl Immunol. 2022 Apr;71:101546. doi: 10.1016/j.trim.2022.101546. Epub 2022 Jan 31. Transpl Immunol. 2022. PMID: 35114361 Free article.
RESULTS: We found the level of RAP1A was higher in patients than in healthy individuals. A negative correlation was noted between RAP1A and the number of Treg cells. ...Furthermore, we found a negative correlation between levels of IL-10 and RAP1A, and a posi …
RESULTS: We found the level of RAP1A was higher in patients than in healthy individuals. A negative correlation was noted between …
Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress.
Burr SD, Dorroh CC, Stewart JA Jr. Burr SD, et al. Int J Mol Sci. 2022 Apr 19;23(9):4480. doi: 10.3390/ijms23094480. Int J Mol Sci. 2022. PMID: 35562872 Free PMC article.
Primary cardiac fibroblasts from non-diabetic and diabetic mice with and without RAGE expression and from mice lacking Rap1a were cultured on tail collagen extracted from non-diabetic or diabetic mice, and in addition, cells were treated with Rap1a activator, EPAC. …
Primary cardiac fibroblasts from non-diabetic and diabetic mice with and without RAGE expression and from mice lacking Rap1a were cul …
Rap1a Overlaps the AGE/RAGE Signaling Cascade to Alter Expression of alpha-SMA, p-NF-kappaB, and p-PKC-zeta in Cardiac Fibroblasts Isolated from Type 2 Diabetic Mice.
Burr SD, Stewart JA Jr. Burr SD, et al. Cells. 2021 Mar 4;10(3):557. doi: 10.3390/cells10030557. Cells. 2021. PMID: 33806572 Free PMC article.
Rap1a acts as a molecular switch connecting extracellular signals to intracellular responses. ...Additionally, knocking down Rap1a expression resulted in an increase in SOD-1 expression suggesting that Rap1a can affect oxidative stress markers independently o …
Rap1a acts as a molecular switch connecting extracellular signals to intracellular responses. ...Additionally, knocking down Rap1a …
Rap1b but not Rap1a in the forebrain is required for learned fear.
Chen WB, Pan HQ, He Y, Wang XH, Zhang WH, Pan BX. Chen WB, et al. Cell Biosci. 2020 Sep 11;10:107. doi: 10.1186/s13578-020-00469-1. eCollection 2020. Cell Biosci. 2020. PMID: 32944221 Free PMC article.
RESULTS: In the present study, employing mice with forebrain-restricted deletion of Rap1a or Rap1b, we found that they are both dispensable for normal acquisition of fear learning. However, Rap1b but not Rap1a knockout (KO) mice displayed impairment in the retrieval …
RESULTS: In the present study, employing mice with forebrain-restricted deletion of Rap1a or Rap1b, we found that they are both dispe …
Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade.
Burr SD, Stewart JA Jr. Burr SD, et al. Cells. 2021 May 22;10(6):1286. doi: 10.3390/cells10061286. Cells. 2021. PMID: 34067282 Free PMC article.
While Rap1a has been shown to impact AGE/RAGE-induced protein expression, there are currently no data examining the impact Rap1a has on AGE/RAGE-induced cardiac fibroblast function. Therefore, we aimed to determine the impact of Rap1a on AGE/RAGE-mediated car …
While Rap1a has been shown to impact AGE/RAGE-induced protein expression, there are currently no data examining the impact Rap1a …
CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression.
Wang W, Wang Q, Sun S, Zhang P, Li Y, Lin W, Li Q, Zhang X, Ma Z, Lu H. Wang W, et al. Int J Oral Sci. 2024 Feb 4;16(1):12. doi: 10.1038/s41368-023-00272-x. Int J Oral Sci. 2024. PMID: 38311610 Free PMC article.
Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion, our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pat …
Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating too …
567 results