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Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models.
Liu J, Liu W, Lu Y, Tian H, Duan C, Lu L, Gao G, Wu X, Wang X, Yang H. Liu J, et al. Autophagy. 2018;14(5):845-861. doi: 10.1080/15548627.2017.1390636. Epub 2018 Feb 21. Autophagy. 2018. PMID: 29433359 Free PMC article.
Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and is caused by genetics, environmental factors and aging, with few treatments currently available. ...ABBREVIATIONS: 6-OHDA, 6-hydroxydopamine; ACTB, actin, …
Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and is caused by ge …
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.
Zhang L, Wang L, Wang R, Gao Y, Che H, Pan Y, Fu P. Zhang L, et al. Med Sci Monit. 2017 Feb 14;23:801-808. doi: 10.12659/msm.898679. Med Sci Monit. 2017. PMID: 28193995 Free PMC article.
BACKGROUND This study was proposed to compare the efficacy and safety of GTM-1, Rapamycin (Rap), and Carbamazepine (CBZ) in managing Alzheimer disease (AD). ...CONCLUSIONS GTM-1 can alleviate the AD syndrome by activating autophagy in a manner that is …
BACKGROUND This study was proposed to compare the efficacy and safety of GTM-1, Rapamycin (Rap), and Carbamazepine (CBZ) in ma …
Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.
Singh AK, Bissoyi A, Kashyap MP, Patra PK, Rizvi SI. Singh AK, et al. Neurotox Res. 2017 Oct;32(3):351-361. doi: 10.1007/s12640-017-9746-5. Epub 2017 May 8. Neurotox Res. 2017. PMID: 28484969
Although autophagy has been implicated in amyloid-beta (Abeta) production and deposition, its role in pathogenesis of Alzheimer's disease remains elusive. Thus, the present study was undertaken to assess the cytoprotective and neuroprotective potential of aut …
Although autophagy has been implicated in amyloid-beta (Abeta) production and deposition, its role in pathogenesis of Alzheimer's …