Rapoport AP - Search Results

1

PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.

Simons-Evelyn M, Bailey-Dell K, Toretsky JA, Ross DD, Fenton R, Kalvakolanu D, Rapoport AP. Simons-Evelyn M, et al. Among authors: rapoport ap. Blood Cells Mol Dis. 2001 Sep-Oct;27(5):825-9. doi: 10.1006/bcmd.2001.0452. Blood Cells Mol Dis. 2001. PMID: 11783945

2

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle PM, Nahm M, Insel RA, Abboud CN. Rapoport AP, et al. Blood Cells Mol Dis. 2001 May-Jun;27(3):610-24. doi: 10.1006/bcmd.2001.0428. Blood Cells Mol Dis. 2001. PMID: 11482875

3

Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells.

Nandi A, Tidwell M, Karp J, Rapoport AP. Nandi A, et al. Among authors: rapoport ap. Blood Cells Mol Dis. 2004 Jan-Feb;32(1):240-5. doi: 10.1016/j.bcmd.2003.10.004. Blood Cells Mol Dis. 2004. PMID: 14757441

4

Phase I clinical trial of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil (cellcept) in advanced multiple myeloma patients.

Takebe N, Cheng X, Wu S, Bauer K, Goloubeva OG, Fenton RG, Heyman M, Rapoport AP, Badros A, Shaughnessy J, Ross D, Meisenberg B, Tricot G. Takebe N, et al. Among authors: rapoport ap. Clin Cancer Res. 2004 Dec 15;10(24):8301-8. doi: 10.1158/1078-0432.CCR-04-0747. Clin Cancer Res. 2004. PMID: 15623606 Clinical Trial.

5

Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53.

Nandi AK, Ford T, Fleksher D, Neuman B, Rapoport AP. Nandi AK, et al. Among authors: rapoport ap. Biochem Biophys Res Commun. 2007 Jun 22;358(1):181-8. doi: 10.1016/j.bbrc.2007.04.125. Epub 2007 Apr 30. Biochem Biophys Res Commun. 2007. PMID: 17482142

6

Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy.

Rapoport AP, Meisenberg B, Sarkodee-Adoo C, Fassas A, Frankel SR, Mookerjee B, Takebe N, Fenton R, Heyman M, Badros A, Kennedy A, Jacobs M, Hudes R, Ruehle K, Smith R, Kight L, Chambers S, MacFadden M, Cottler-Fox M, Chen T, Phillips G, Tricot G. Rapoport AP, et al. Bone Marrow Transplant. 2002 Feb;29(4):303-12. doi: 10.1038/sj.bmt.1703363. Bone Marrow Transplant. 2002. PMID: 11896427 Free PMC article.

7

c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.

Hu F, Gartenhaus RB, Zhao XF, Fang HB, Minkove S, Poss DE, Rapoport AP. Hu F, et al. Among authors: rapoport ap. Leuk Res. 2013 Apr;37(4):447-54. doi: 10.1016/j.leukres.2012.11.010. Epub 2012 Dec 10. Leuk Res. 2013. PMID: 23237560

8

PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.

Hu F, Gartenhaus RB, Eichberg D, Liu Z, Fang HB, Rapoport AP. Hu F, et al. Among authors: rapoport ap. Oncogene. 2010 Oct 7;29(40):5464-74. doi: 10.1038/onc.2010.275. Epub 2010 Jul 12. Oncogene. 2010. PMID: 20622899

9

Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients.

Badros AZ, Goloubeva O, Rapoport AP, Ratterree B, Gahres N, Meisenberg B, Takebe N, Heyman M, Zwiebel J, Streicher H, Gocke CD, Tomic D, Flaws JA, Zhang B, Fenton RG. Badros AZ, et al. Among authors: rapoport ap. J Clin Oncol. 2005 Jun 20;23(18):4089-99. doi: 10.1200/JCO.2005.14.381. Epub 2005 May 2. J Clin Oncol. 2005. PMID: 15867202 Clinical Trial.

10

Expression of PDZ-binding kinase (PBK) is regulated by cell cycle-specific transcription factors E2F and CREB/ATF.

Nandi AK, Rapoport AP. Nandi AK, et al. Among authors: rapoport ap. Leuk Res. 2006 Apr;30(4):437-47. doi: 10.1016/j.leukres.2005.08.011. Epub 2005 Sep 19. Leuk Res. 2006. PMID: 16171862

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