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Phagocytic signaling: you can touch, but you can't eat.
Kinchen JM, Ravichandran KS. Kinchen JM, et al. Among authors: ravichandran ks. Curr Biol. 2008 Jun 24;18(12):R521-4. doi: 10.1016/j.cub.2008.04.058. Curr Biol. 2008. PMID: 18579095 Free PMC article.
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS. Gumienny TL, et al. Among authors: ravichandran ks. Cell. 2001 Oct 5;107(1):27-41. doi: 10.1016/s0092-8674(01)00520-7. Cell. 2001. PMID: 11595183 Free article.
PH domain of ELMO functions in trans to regulate Rac activation via Dock180.
Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS. Lu M, et al. Among authors: ravichandran ks. Nat Struct Mol Biol. 2004 Aug;11(8):756-62. doi: 10.1038/nsmb800. Epub 2004 Jul 11. Nat Struct Mol Biol. 2004. PMID: 15247908
211 results