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Rearrangements of NTRK1 gene in papillary thyroid carcinoma.
Greco A, Miranda C, Pierotti MA. Greco A, et al. Mol Cell Endocrinol. 2010 May 28;321(1):44-9. doi: 10.1016/j.mce.2009.10.009. Epub 2009 Oct 31. Mol Cell Endocrinol. 2010. PMID: 19883730 Review.
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such …
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of …
Detection of NTRK1/3 Rearrangements in Papillary Thyroid Carcinoma Using Immunohistochemistry, Fluorescent In Situ Hybridization, and Next-Generation Sequencing.
Lee YC, Chen JY, Huang CJ, Chen HS, Yang AH, Hang JF. Lee YC, et al. Endocr Pathol. 2020 Dec;31(4):348-358. doi: 10.1007/s12022-020-09648-9. Epub 2020 Sep 3. Endocr Pathol. 2020. PMID: 32880785
NTRK1/3 rearrangements have been reported in 2.3-3.4% of papillary thyroid carcinoma (PTC) and are regarded as potential therapeutic targets. ...As a result, pan-TRK IHC showed a sensitivity of 58.3% and specificity of 100% for NTRK1/3 …
NTRK1/3 rearrangements have been reported in 2.3-3.4% of papillary thyroid carcinoma (PTC) and are regard …
Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma.
Brzeziańska E, Pastuszak-Lewandoska D, Lewiński A. Brzeziańska E, et al. Neuro Endocrinol Lett. 2007 Jun;28(3):221-9. Neuro Endocrinol Lett. 2007. PMID: 17627253 Review.
Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of oncogenic sequences, such as RET/PTC and Trk. Both of them arise from the fusion of 3' terminal sequences of TK domain of RET or NTRK1 gene, respectively, w …
Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of oncogenic sequences, such as R …
Rearrangements of RET and NTRK1 tyrosine kinase receptors in papillary thyroid carcinomas.
Pierotti MA, Vigneri P, Bongarzone I. Pierotti MA, et al. Recent Results Cancer Res. 1998;154:237-47. doi: 10.1007/978-3-642-46870-4_15. Recent Results Cancer Res. 1998. PMID: 10027004 Review.
In particular, the well-differentiated carcinomas of the papillary type are characterised by the activation of the tyrosine kinase receptors (TKRs) RET and NTRK1 proto-oncogenes. ...The results have shown that, in the majority of the cases, intra-chromosomal inversi …
In particular, the well-differentiated carcinomas of the papillary type are characterised by the activation of the tyrosine kinase re …
A Detailed Histologic and Molecular Assessment of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma.
Chou A, Qiu MR, Crayton H, Wang B, Ahadi MS, Turchini J, Clarkson A, Sioson L, Sheen A, Singh N, Clifton-Bligh RJ, Robinson BG, Gild ML, Tsang V, Leong D, Sidhu SB, Sywak M, Delbridge L, Aniss A, Wright D, Graf N, Kumar A, Rathi V, Benitez-Aguirre P, Glover AR, Gill AJ. Chou A, et al. Mod Pathol. 2023 Dec;36(12):100329. doi: 10.1016/j.modpat.2023.100329. Epub 2023 Sep 15. Mod Pathol. 2023. PMID: 37716505 Free article.
Diffuse sclerosing variant papillary thyroid carcinoma (DS-PTC) is characterized clinically by a predilection for children and young adults, bulky neck nodes, and pulmonary metastases. ...We conclude that DS-PTC represents 1.9% of papillary thyroid …
Diffuse sclerosing variant papillary thyroid carcinoma (DS-PTC) is characterized clinically by a predilection for child …
Clinicopathological significance of major fusion oncogenes in papillary thyroid carcinoma: An individual patient data meta-analysis.
Vuong HG, Le HT, Le TTB, Le T, Hassell L, Kakudo K. Vuong HG, et al. Pathol Res Pract. 2022 Dec;240:154180. doi: 10.1016/j.prp.2022.154180. Epub 2022 Oct 21. Pathol Res Pract. 2022. PMID: 36306725 Review.
INTRODUCTION: Fusion oncogenes (e.g., NTRK, RET, ALK, BRAF) are rare genetic events in papillary thyroid carcinoma (PTC). It is still unclear regarding the similarities and differences in clinicopathological manifestations and prognostic outcomes of these gen …
INTRODUCTION: Fusion oncogenes (e.g., NTRK, RET, ALK, BRAF) are rare genetic events in papillary thyroid carcinoma (PTC …
NTRK Fusion in a Cohort of BRAF p. V600E Wild-Type Papillary Thyroid Carcinomas.
Lee SE, Lee MS, Bang H, Kim MY, Choi YL, Oh YL. Lee SE, et al. Mod Pathol. 2023 Aug;36(8):100180. doi: 10.1016/j.modpat.2023.100180. Epub 2023 Mar 30. Mod Pathol. 2023. PMID: 37003481 Free article.
Owing to the availability of a potent tropomyosin receptor kinase (TRK) inhibitor, it is necessary to develop an effective strategy to identify an enriched population of NTRK fusions in papillary thyroid carcinoma (PTC) in routine diagnostic practice. The rep …
Owing to the availability of a potent tropomyosin receptor kinase (TRK) inhibitor, it is necessary to develop an effective strategy to ident …
Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma.
Créancier L, Vandenberghe I, Gomes B, Dejean C, Blanchet JC, Meilleroux J, Guimbaud R, Selves J, Kruczynski A. Créancier L, et al. Cancer Lett. 2015 Aug 28;365(1):107-11. doi: 10.1016/j.canlet.2015.05.013. Epub 2015 May 19. Cancer Lett. 2015. PMID: 26001971
Chromosomal rearrangements of the NTRK1 gene, which encodes the high affinity nerve growth factor receptor (tropomyosin related kinase, TRKA), have been observed in several epithelial cancers, such as colon cancer, papillary thyroid ca …
Chromosomal rearrangements of the NTRK1 gene, which encodes the high affinity nerve growth factor receptor (tropomyosin …
Genomic landscape of metastatic papillary thyroid carcinoma and novel biomarkers for predicting distant metastasis.
Lan X, Bao H, Ge X, Cao J, Fan X, Zhang Q, Liu K, Zhang X, Tan Z, Zheng C, Wang A, Chen C, Zhu X, Wang J, Xu J, Zhu X, Wu X, Wang X, Shao Y, Ge M. Lan X, et al. Cancer Sci. 2020 Jun;111(6):2163-2173. doi: 10.1111/cas.14389. Epub 2020 Apr 16. Cancer Sci. 2020. PMID: 32187423 Free PMC article.
Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland, with a relatively high cure rate. ...BRAF-V600E was identified in 73% of PTC, followed by RET fusions (14%) in a mutually exclusive manner (P < 0.0001). We found t …
Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland, with a relatively high cur …
Novel TG-FGFR1 and TRIM33-NTRK1 transcript fusions in papillary thyroid carcinoma.
Pfeifer A, Rusinek D, Żebracka-Gala J, Czarniecka A, Chmielik E, Zembala-Nożyńska E, Wojtaś B, Gielniewski B, Szpak-Ulczok S, Oczko-Wojciechowska M, Krajewska J, Polańska J, Jarząb B. Pfeifer A, et al. Genes Chromosomes Cancer. 2019 Aug;58(8):558-566. doi: 10.1002/gcc.22737. Epub 2019 Feb 18. Genes Chromosomes Cancer. 2019. PMID: 30664823 Free PMC article.
Papillary thyroid carcinoma (PTC) is most common among all thyroid cancers. Multiple genomic alterations occur in PTC, and gene rearrangements are one of them. ...We detected 2 novel potentially oncogenic transcript fusions: TG-FGFR1 and …
Papillary thyroid carcinoma (PTC) is most common among all thyroid cancers. Multiple genomic alterations occur i …
62 results