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C-25 hydroxylation of 1alpha,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1.
Astecker N, Bobrovnikova EA, Omdahl JL, Gennaro L, Vouros P, Schuster I, Uskokovic MR, Ishizuka S, Wang G, Reddy GS. Astecker N, et al. Among authors: reddy gs. Arch Biochem Biophys. 2004 Nov 15;431(2):261-70. doi: 10.1016/j.abb.2004.08.023. Arch Biochem Biophys. 2004. PMID: 15488475
23-carboxy-24,25,26,27-tetranorvitamin D3 (calcioic acid) and 24-carboxy-25,26,27-trinorvitamin D3 (cholacalcioic acid): end products of 25-hydroxyvitamin D3 metabolism in rat kidney through C-24 oxidation pathway.
Reddy GS, Omdahl JL, Robinson M, Wang G, Palmore GT, Vicchio D, Yergey AL, Tserng KY, Uskokovic MR. Reddy GS, et al. Arch Biochem Biophys. 2006 Nov 1;455(1):18-30. doi: 10.1016/j.abb.2006.08.021. Epub 2006 Sep 15. Arch Biochem Biophys. 2006. PMID: 17027908
1alpha,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1alpha,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells.
Siu-Caldera ML, Clark JW, Santos-Moore A, Peleg S, Liu YY, Uskoković MR, Sharma S, Reddy GS. Siu-Caldera ML, et al. Among authors: reddy gs. J Steroid Biochem Mol Biol. 1996 Dec;59(5-6):405-12. doi: 10.1016/s0960-0760(96)00134-3. J Steroid Biochem Mol Biol. 1996. PMID: 9010346
Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.
Siu-Caldera ML, Sekimoto H, Weiskopf A, Vouros P, Muralidharan KR, Okamura WH, Bishop J, Norman AW, Uskoković MR, Schuster I, Reddy GS. Siu-Caldera ML, et al. Among authors: reddy gs. Bone. 1999 May;24(5):457-63. doi: 10.1016/s8756-3282(99)00019-8. Bone. 1999. PMID: 10321905
Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. Among authors: reddy gs. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699
294 results