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VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.
Reed CW, McGowan KM, Spearing PK, Stansley BJ, Roenfanz HF, Engers DW, Rodriguez AL, Engelberg EM, Luscombe VB, Loch MT, Remke DH, Rook JM, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Reed CW, et al. ACS Med Chem Lett. 2017 Nov 8;8(12):1326-1330. doi: 10.1021/acsmedchemlett.7b00429. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259756 Free PMC article.
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962).
Reed CW, Yohn SE, Washecheck JP, Roenfanz HF, Quitalig MC, Luscombe VB, Jenkins MT, Rodriguez AL, Engers DW, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Reed CW, et al. J Med Chem. 2019 Feb 14;62(3):1690-1695. doi: 10.1021/acs.jmedchem.8b01810. Epub 2019 Jan 17. J Med Chem. 2019. PMID: 30608678 Free PMC article.
Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core.
Kalbfleisch JJ, Reed CW, Park C, Spearing PK, Quitalig MC, Jenkins MT, Rodriguez AL, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Kalbfleisch JJ, et al. Among authors: reed cw. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127529. doi: 10.1016/j.bmcl.2020.127529. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890686 Free PMC article.
Use of chemical probes to explore the toxicological potential of the K+/Cl- cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika virus, Aedes aegypti.
Prael FJ 3rd, Chen R, Li Z, Reed CW, Lindsley CW, Weaver CD, Swale DR. Prael FJ 3rd, et al. Among authors: reed cw. Pestic Biochem Physiol. 2018 Oct;151:10-17. doi: 10.1016/j.pestbp.2018.03.019. Epub 2018 Apr 6. Pestic Biochem Physiol. 2018. PMID: 30704707 Free article.
Formal Total Synthesis of Pericoannosin A.
Fulton MG, Bertron JL, Reed CW, Lindsley CW. Fulton MG, et al. Among authors: reed cw. J Org Chem. 2019 Sep 20;84(18):12187-12191. doi: 10.1021/acs.joc.9b01846. Epub 2019 Sep 4. J Org Chem. 2019. PMID: 31436090
20 results