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Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells.
Fauser F, Kadam BN, Arangundy-Franklin S, Davis JE, Vaidya V, Schmidt NJ, Lew G, Xia DF, Mureli R, Ng C, Zhou Y, Scarlott NA, Eshleman J, Bendaña YR, Shivak DA, Reik A, Li P, Davis GD, Miller JC. Fauser F, et al. Among authors: reik a. Nat Commun. 2024 Feb 15;15(1):1181. doi: 10.1038/s41467-024-45100-w. Nat Commun. 2024. PMID: 38360922 Free PMC article.
Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma.
Brown CE, Rodriguez A, Palmer J, Ostberg JR, Naranjo A, Wagner JR, Aguilar B, Starr R, Weng L, Synold TW, Tran V, Wang S, Reik A, D'Apuzzo M, Ressler JA, Zhou Y, Mendel M, Gregory PD, Holmes MC, Tang WW, Forman SJ, Jensen MC, Badie B. Brown CE, et al. Among authors: reik a. Neuro Oncol. 2022 Aug 1;24(8):1318-1330. doi: 10.1093/neuonc/noac024. Neuro Oncol. 2022. PMID: 35100373 Free PMC article. Clinical Trial.
Enhancing gene editing specificity by attenuating DNA cleavage kinetics.
Miller JC, Patil DP, Xia DF, Paine CB, Fauser F, Richards HW, Shivak DA, Bendaña YR, Hinkley SJ, Scarlott NA, Lam SC, Reik A, Zhou Y, Paschon DE, Li P, Wangzor T, Lee G, Zhang L, Rebar EJ. Miller JC, et al. Among authors: reik a. Nat Biotechnol. 2019 Aug;37(8):945-952. doi: 10.1038/s41587-019-0186-z. Epub 2019 Jul 29. Nat Biotechnol. 2019. PMID: 31359006
38 results