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Structure-Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity.
Albanese V, Ruzza C, Marzola E, Bernardi T, Fabbri M, Fantinati A, Trapella C, Reinscheid RK, Ferrari F, Sturaro C, Calò G, Amendola G, Cosconati S, Pacifico S, Guerrini R, Preti D. Albanese V, et al. Among authors: reinscheid rk. J Med Chem. 2021 Apr 8;64(7):4089-4108. doi: 10.1021/acs.jmedchem.0c02223. Epub 2021 Mar 18. J Med Chem. 2021. PMID: 33733768 Free PMC article.
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
Trapella C, Pela M, Del Zoppo L, Calo G, Camarda V, Ruzza C, Cavazzini A, Costa V, Bertolasi V, Reinscheid RK, Salvadori S, Guerrini R. Trapella C, et al. Among authors: reinscheid rk. J Med Chem. 2011 Apr 28;54(8):2738-44. doi: 10.1021/jm200138r. Epub 2011 Apr 5. J Med Chem. 2011. PMID: 21466221 Free PMC article.
96 results