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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 8
1964 21
1965 4
1967 1
1972 1
1974 1
1975 2
1976 9
1977 13
1978 15
1979 11
1980 17
1981 14
1982 9
1983 19
1984 12
1985 5
1986 9
1987 10
1988 9
1989 11
1990 10
1991 9
1992 10
1993 31
1994 71
1995 81
1996 94
1997 123
1998 131
1999 144
2000 169
2001 169
2002 182
2003 211
2004 296
2005 327
2006 362
2007 457
2008 491
2009 512
2010 527
2011 603
2012 606
2013 694
2014 695
2015 727
2016 710
2017 660
2018 734
2019 777
2020 751
2021 789
2022 529
2023 430
2024 191

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12,040 results

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Page 1
RELA governs a network of islet-specific metabolic genes necessary for beta cell function.
Zammit NW, Wong YY, Walters SN, Warren J, Barry SC, Grey ST. Zammit NW, et al. Diabetologia. 2023 Aug;66(8):1516-1531. doi: 10.1007/s00125-023-05931-6. Epub 2023 Jun 14. Diabetologia. 2023. PMID: 37311878 Free PMC article.
However, Rela deletion also rendered mice glucose intolerant because of functional loss of insulin secretion. ...CONCLUSIONS/INTERPRETATION: These data demonstrate an unappreciated role for RELA as a regulator of islet-specific transcriptional programmes necessary f …
However, Rela deletion also rendered mice glucose intolerant because of functional loss of insulin secretion. ...CONCLUSIONS/INTERPRE …
relA Inactivation Converts Sulfonamides Into Bactericidal Compounds.
Si L, Gu J, Wen M, Wang R, Fleming J, Li J, Xu J, Bi L, Deng J. Si L, et al. Front Microbiol. 2021 Sep 27;12:698468. doi: 10.3389/fmicb.2021.698468. eCollection 2021. Front Microbiol. 2021. PMID: 34646242 Free PMC article.
Sulfonamides, which inhibit bacterial folate biosynthesis and are generally considered as bacteriostats, have been extensively used as broad-spectrum antimicrobials for decades. Here we show that, deleting relA in Escherichia coli and other bacterial species converted sulf …
Sulfonamides, which inhibit bacterial folate biosynthesis and are generally considered as bacteriostats, have been extensively used as broad …
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
Nakazato A, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Fujii K, Saijoh S, Morita S, Yamazaki T, Imai T, Sato I, Satoh K, Yamaguchi K, Sugamura K, Yasuda J, Matsuura K, Shojaku H, Asada Y, Tamai K. Nakazato A, et al. Sci Rep. 2022 Oct 22;12(1):17751. doi: 10.1038/s41598-022-22736-6. Sci Rep. 2022. PMID: 36273237 Free PMC article.
Additionally, we found that clinical tissue samples showing elevated CD271 expression were enriched in RELA-binding sites and that HPC tissues showed elevated levels of both CD271 and phosphorylated RELA. These data suggested that RELA increases CD271 express …
Additionally, we found that clinical tissue samples showing elevated CD271 expression were enriched in RELA-binding sites and that HP …
RELA promotes the progression of oral squamous cell carcinoma via TFAP2A-Wnt/beta-catenin signaling.
Yang K, Zhao J, Liu S, Man S. Yang K, et al. Mol Carcinog. 2023 May;62(5):641-651. doi: 10.1002/mc.23512. Epub 2023 Feb 15. Mol Carcinog. 2023. PMID: 36789977
Furthermore, TFAP2A activated the Wnt/beta-catenin signaling by targeting the promoter regions of beta-catenin. The study found that RELA is critical for promoting the progression of OSCC via the RELA-TFAP2A-Wnt/beta-catenin signaling pathway. The RELA-TFAP2A …
Furthermore, TFAP2A activated the Wnt/beta-catenin signaling by targeting the promoter regions of beta-catenin. The study found that RELA …
C11orf95-RELA reprograms 3D epigenome in supratentorial ependymoma.
Zhu JJ, Jillette N, Li XN, Cheng AW, Lau CC. Zhu JJ, et al. Acta Neuropathol. 2020 Dec;140(6):951-960. doi: 10.1007/s00401-020-02225-8. Epub 2020 Sep 9. Acta Neuropathol. 2020. PMID: 32909151 Free PMC article.
Since 2014, it has been known that an intrachromosomal fusion C11orf95-RELA is an oncogenic driver in ST-EPN [Parker et al. Nature 506:451-455 (2014); Pietsch et al. ...Our findings provide important characterization of the molecular underpinning of C11orf95-RELA fu …
Since 2014, it has been known that an intrachromosomal fusion C11orf95-RELA is an oncogenic driver in ST-EPN [Parker et al. Nature 50 …
Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis.
Feng Y, Dong H, Zheng L. Feng Y, et al. Pharm Biol. 2023 Dec;61(1):666-673. doi: 10.1080/13880209.2023.2195883. Pharm Biol. 2023. PMID: 37095705 Free PMC article.
Ligustrazine inhibited the expression of p-STAT3, IGF2BP1, RELA, IL-6, TNF-alpha, and IL-1beta. Overexpression of STAT3 promoted RELA-mediated inflammatory responses, while ligustrazine (100 M) notably reversed this phenomenon. Ligustrazine also alleviated RELA …
Ligustrazine inhibited the expression of p-STAT3, IGF2BP1, RELA, IL-6, TNF-alpha, and IL-1beta. Overexpression of STAT3 promoted R …
Negative regulation of RelA phosphorylation: emerging players and their roles in cancer.
Lu X, Yarbrough WG. Lu X, et al. Cytokine Growth Factor Rev. 2015 Feb;26(1):7-13. doi: 10.1016/j.cytogfr.2014.09.003. Epub 2014 Oct 2. Cytokine Growth Factor Rev. 2015. PMID: 25438737 Review.
Many advances have been made in understanding mechanisms responsible for abnormal NF-kappaB activation with RelA post-translational modification, particularly phosphorylation, proven to be critical for RelA function. While the majority of studies have focused on ide …
Many advances have been made in understanding mechanisms responsible for abnormal NF-kappaB activation with RelA post-translational m …
RelA: a tale of a stitch in time.
Korc M. Korc M. J Clin Invest. 2016 Aug 1;126(8):2799-801. doi: 10.1172/JCI89156. Epub 2016 Jul 25. J Clin Invest. 2016. PMID: 27454293 Free PMC article.
The beneficial effects of RelA were mediated by increased expression of CXCL1 and its activation of CXCR2. By contrast, in advanced stages of Kras-driven murine PDAC, loss of p53 or p16 was associated with senescence bypass, and RelA deficiency in this context atten …
The beneficial effects of RelA were mediated by increased expression of CXCL1 and its activation of CXCR2. By contrast, in advanced s …
Supratentorial ependymoma in childhood: more than just RELA or YAP.
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T. Zschernack V, et al. Acta Neuropathol. 2021 Mar;141(3):455-466. doi: 10.1007/s00401-020-02260-5. Epub 2021 Jan 22. Acta Neuropathol. 2021. PMID: 33481105 Free PMC article.
Based upon histological and immunohistochemical features two main patterns were identified-RELA-like (n = 9) and tanycytic ependymomas (n = 6). In the RELA-like group histologically assigned to WHO grade III and resembling RELA-fused ependymomas, tumors lacke …
Based upon histological and immunohistochemical features two main patterns were identified-RELA-like (n = 9) and tanycytic ependymoma …
Case report: Novel variants in RELA associated with familial Behcet's-like disease.
An JW, Pimpale-Chavan P, Stone DL, Bandeira M, Dedeoglu F, Lo J, Bohnsack J, Rosenzweig S, Schnappauf O, Dissanayake D, Hiraki LT, Kastner DL, Pelajo C, Laxer RM, Aksentijevich I. An JW, et al. Front Immunol. 2023 Feb 28;14:1127085. doi: 10.3389/fimmu.2023.1127085. eCollection 2023. Front Immunol. 2023. PMID: 36926348 Free PMC article.
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-kappaB family transcription factors. ...
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulce …
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