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Showing results for research and review: Journal of Pharmaceutical Analysis
Your search for Research and Reviews: Journal of Pharmaceutical Analysis retrieved no results
Machine Learning and Artificial Intelligence in Pharmaceutical Research and Development: a Review.
Kolluri S, Lin J, Liu R, Zhang Y, Zhang W. Kolluri S, et al. AAPS J. 2022 Jan 4;24(1):19. doi: 10.1208/s12248-021-00644-3. AAPS J. 2022. PMID: 34984579 Free PMC article. Review.
Over the past decade, artificial intelligence (AI) and machine learning (ML) have become the breakthrough technology most anticipated to have a transformative effect on pharmaceutical research and development (R&D). This is partially driven by revolutionary adva …
Over the past decade, artificial intelligence (AI) and machine learning (ML) have become the breakthrough technology most anticipated to hav …
Design of experiments (DoE) in pharmaceutical development.
N Politis S, Colombo P, Colombo G, M Rekkas D. N Politis S, et al. Drug Dev Ind Pharm. 2017 Jun;43(6):889-901. doi: 10.1080/03639045.2017.1291672. Epub 2017 Feb 23. Drug Dev Ind Pharm. 2017. PMID: 28166428 Review.
At the beginning of the twentieth century, Sir Ronald Fisher introduced the concept of applying statistical analysis during the planning stages of research rather than at the end of experimentation. ...As such, DoE is presented in detail since it represents the firs …
At the beginning of the twentieth century, Sir Ronald Fisher introduced the concept of applying statistical analysis during the plann …
Real-World Evidence: A Primer.
Dang A. Dang A. Pharmaceut Med. 2023 Jan;37(1):25-36. doi: 10.1007/s40290-022-00456-6. Epub 2023 Jan 5. Pharmaceut Med. 2023. PMID: 36604368 Free PMC article. Review.
There has been an increasing awareness and acceptance of RWE from different stakeholders, including physicians, pharmaceutical companies, payers, regulators, and patients. Several regulatory authorities have also created frameworks and guidelines for efficient harnessing o …
There has been an increasing awareness and acceptance of RWE from different stakeholders, including physicians, pharmaceutical compan …
Multi-omics research strategies in ischemic stroke: A multidimensional perspective.
Li W, Shao C, Zhou H, Du H, Chen H, Wan H, He Y. Li W, et al. Ageing Res Rev. 2022 Nov;81:101730. doi: 10.1016/j.arr.2022.101730. Epub 2022 Sep 7. Ageing Res Rev. 2022. PMID: 36087702 Review.
The integration of multiple omics data means the simultaneous analysis of thousands of genes, RNAs, proteins and metabolites, revealing networks of interactions between multiple molecular levels. Integrated analysis of multi-omics approaches will provide helpful ins …
The integration of multiple omics data means the simultaneous analysis of thousands of genes, RNAs, proteins and metabolites, reveali …
The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials.
Catalá-López F, Hutton B, Núñez-Beltrán A, Mayhew AD, Page MJ, Ridao M, Tobías A, Catalá MA, Tabarés-Seisdedos R, Moher D. Catalá-López F, et al. Syst Rev. 2015 Feb 27;4:19. doi: 10.1186/s13643-015-0005-7. Syst Rev. 2015. PMID: 25875125 Free PMC article.
Random-effects pairwise meta-analyses and Bayesian network meta-analyses will be conducted where appropriate. DISCUSSION: This systematic review and network meta-analysis will compare the efficacy and safety of treatments used for ADHD in children and adolescents. T …
Random-effects pairwise meta-analyses and Bayesian network meta-analyses will be conducted where appropriate. DISCUSSION: This systematic …
Current state of fabrication technologies and materials for bone tissue engineering.
Wubneh A, Tsekoura EK, Ayranci C, Uludağ H. Wubneh A, et al. Acta Biomater. 2018 Oct 15;80:1-30. doi: 10.1016/j.actbio.2018.09.031. Epub 2018 Sep 22. Acta Biomater. 2018. PMID: 30248515 Review.
STATEMENT OF SIGNIFICANCE: The manuscript summarizes the current state of fabrication technologies and materials used for creating scaffolds in bone tissue engineering applications. A comprehensive analysis of different fabrication methods (traditional and free-form) were …
STATEMENT OF SIGNIFICANCE: The manuscript summarizes the current state of fabrication technologies and materials used for creating scaffolds …
Applications of proteomics in pharmaceutical research and development.
Yokota H. Yokota H. Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867(1):17-21. doi: 10.1016/j.bbapap.2018.05.008. Epub 2018 May 9. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 29753086 Review.
This review discusses recent proteomics publications from pharmaceutical companies to identify new trends in proteomics applications to research and development. ...Technological advancements in proteomics will further accelerate pharmaceutical rese …
This review discusses recent proteomics publications from pharmaceutical companies to identify new trends in proteomics applic …
Data linkage.
Emery J, Boyle D. Emery J, et al. Aust Fam Physician. 2017;46(8):615-619. Aust Fam Physician. 2017. PMID: 28787562 Review.
OBJECTIVE: This paper provides an overview of data linkage and its relevance to general practice research. DISCUSSION: Data linkage enables large-scale studies of whole populations across the healthcare system. ...This can be achieved through access to Medicare data (Medic …
OBJECTIVE: This paper provides an overview of data linkage and its relevance to general practice research. DISCUSSION: Data linkage e …
Regulatory review time and pharmaceutical research and development.
Chorniy A, Bailey J, Civan A, Maloney M. Chorniy A, et al. Health Econ. 2021 Jan;30(1):113-128. doi: 10.1002/hec.4180. Epub 2020 Oct 19. Health Econ. 2021. PMID: 33078483
In the United States, all newly developed drugs undergo a lengthy review process conducted by the US Food and Drug Administration (FDA). ...Under certain market conditions, regulatory delays may also affect future research and development (R&D) strategies of …
In the United States, all newly developed drugs undergo a lengthy review process conducted by the US Food and Drug Administration (FD …
Recent Advances in Construction and Application of Metal-Nanozymes in Pharmaceutical Analysis.
Xi L, Jiang C, Wang F, Zhang X, Huo D, Sun M, Dramou P, He H. Xi L, et al. Crit Rev Anal Chem. 2022 Oct 2:1-19. doi: 10.1080/10408347.2022.2128632. Online ahead of print. Crit Rev Anal Chem. 2022. PMID: 36183252 Review.
Nanozymes, made of emerging nanomaterials, have similar activity to natural enzyme and exhibit promising applications in in the fields of environment, biology and medicine, and food safety science. In recent years, with the deep finding and research to nanozymes by rese …
Nanozymes, made of emerging nanomaterials, have similar activity to natural enzyme and exhibit promising applications in in the fields of en …
A 30-year bibliometric analysis of research coverage on HIV and AIDS in Lesotho.
Mugomeri E, Bekele BS, Mafaesa M, Maibvise C, Tarirai C, Aiyuk SE. Mugomeri E, et al. Health Res Policy Syst. 2017 Mar 21;15(1):21. doi: 10.1186/s12961-017-0183-y. Health Res Policy Syst. 2017. PMID: 28320397 Free PMC article. Review.
CONCLUSION: Notwithstanding a considerable research output on HIV/AIDS for Lesotho, there is insufficient coverage of the national research agenda in this research area. The major research gaps on general research output are in basic and prevent …
CONCLUSION: Notwithstanding a considerable research output on HIV/AIDS for Lesotho, there is insufficient coverage of the national …
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research.
Yin J, You N, Li F, Lu M, Zeng S, Zhu F. Yin J, et al. Curr Drug Metab. 2023;24(3):162-174. doi: 10.2174/1389200224666230523155759. Curr Drug Metab. 2023. PMID: 37226790 Review.
With the increasing volume of relevant omics datasets and the rapid evolution of artificial intelligence (AI) techniques, next-generation AI is becoming increasingly prevalent in the functional and pharmaceutical research of transporters. Thus, a comprehensive discu …
With the increasing volume of relevant omics datasets and the rapid evolution of artificial intelligence (AI) techniques, next-generation AI …
Critical analysis of valuation and strategical orientation of merger and acquisition deals in the pharmaceutical industry.
Dierks RML, Bruyère O, Reginster JY. Dierks RML, et al. Expert Rev Pharmacoecon Outcomes Res. 2018 Apr;18(2):147-160. doi: 10.1080/14737167.2018.1417040. Epub 2017 Dec 20. Expert Rev Pharmacoecon Outcomes Res. 2018. PMID: 29243501 Free article. Review.
INTRODUCTION: The pharmaceutical industry is undergoing major shifts due to changing macro and micro factors. ...AREAS COVERED: The paper is based on empirical study questioning existing literature in order to critically analyse valuation and the strategical orientation of …
INTRODUCTION: The pharmaceutical industry is undergoing major shifts due to changing macro and micro factors. ...AREAS COVERED: The p …
Application and utility of geographic information systems in pharmacy specific health research: A scoping review.
Fernandes BD, Foppa AA, Almeida PHRF, Lakhani A, Lima TM. Fernandes BD, et al. Res Social Adm Pharm. 2022 Aug;18(8):3263-3271. doi: 10.1016/j.sapharm.2021.11.004. Epub 2021 Nov 15. Res Social Adm Pharm. 2022. PMID: 34836813 Review.
BACKGROUND: Geographic Information Systems (GIS) are considered essential tools to analyze spatially referenced health data. OBJECTIVES: The purpose of this scoping review is to describe how GIS is used in pharmacy specific health research. ...CONCLUSIONS: GIS have …
BACKGROUND: Geographic Information Systems (GIS) are considered essential tools to analyze spatially referenced health data. OBJECTIVES: The …
Evolution of consciousness of exposure to siloxanes-review of publications.
Mojsiewicz-Pieńkowska K, Krenczkowska D. Mojsiewicz-Pieńkowska K, et al. Chemosphere. 2018 Jan;191:204-217. doi: 10.1016/j.chemosphere.2017.10.045. Epub 2017 Oct 9. Chemosphere. 2018. PMID: 29035792 Review.
Not only the research area, but first, the changes in the tendency of research aims are important issues in the evaluation. ...Analyzing the results from the SCOPUS database, it can be argued that the increased interest of scientists and government agencies particul …
Not only the research area, but first, the changes in the tendency of research aims are important issues in the evaluation. .. …
Metabolomics meets systems immunology.
Fu J, Zhu F, Xu CJ, Li Y. Fu J, et al. EMBO Rep. 2023 Apr 5;24(4):e55747. doi: 10.15252/embr.202255747. Epub 2023 Mar 14. EMBO Rep. 2023. PMID: 36916532 Free PMC article. Review.
Then, we provide a comprehensive overview of the analysis workflow and the computational tools available, including sample preparation, raw spectra data preprocessing, data processing, statistical analysis, and interpretation. ...Finally, we discuss new developments …
Then, we provide a comprehensive overview of the analysis workflow and the computational tools available, including sample preparatio …
[Pharmaceutical Research and Education].
Arai K. Arai K. Yakugaku Zasshi. 2020;140(9):1107-1117. doi: 10.1248/yakushi.20-00123. Yakugaku Zasshi. 2020. PMID: 32879243 Free article. Review. Japanese.
The true central aim of pharmaceutical research and education is to strive for the patient's satisfaction, i.e., "for the sake of the patient". Our research focuses to bridge the gap between the ideal and current situation in pharmaceutical science. .. …
The true central aim of pharmaceutical research and education is to strive for the patient's satisfaction, i.e., "for the sake …
Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report.
Brazier J, Ara R, Azzabi I, Busschbach J, Chevrou-Séverac H, Crawford B, Cruz L, Karnon J, Lloyd A, Paisley S, Pickard AS. Brazier J, et al. Value Health. 2019 Mar;22(3):267-275. doi: 10.1016/j.jval.2019.01.004. Value Health. 2019. PMID: 30832964 Free article. Review.
Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, which rarely happens, analysts typically need to identify at least some additional HSUs from alternative sources. When possible, HSUs are ide …
Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, w …
[Research on pharmacometabolomics].
Zhang ZX, Gao XY. Zhang ZX, et al. Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(6):1093-1098. doi: 10.19540/j.cnki.cjcmm.20180104.020. Zhongguo Zhong Yao Za Zhi. 2018. PMID: 29676113 Review. Chinese.
Recently, it has been widely used in individualized medicine research. The research process of pharmacometabolomic can be divided into three parts: metabolomic study of baseline samples, drug response analysis after drug administration and statistical anal …
Recently, it has been widely used in individualized medicine research. The research process of pharmacometabolomic can be divi …
A scoping review of therapeutic reasoning process research.
Duong QH, Pham TN, Reynolds L, Yeap Y, Walker S, Lyons K. Duong QH, et al. Adv Health Sci Educ Theory Pract. 2023 Oct;28(4):1289-1310. doi: 10.1007/s10459-022-10187-7. Epub 2023 Apr 12. Adv Health Sci Educ Theory Pract. 2023. PMID: 37043070 Free PMC article. Review.
Search terms captured therapeutic reasoning in health professions education research. Initial search yielded 5450 articles. The title and abstract screening yielded 180 articles. After full-text review, 87 studies were included in this review. Articles were e …
Search terms captured therapeutic reasoning in health professions education research. Initial search yielded 5450 articles. The title …
Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals.
Al-Sulaimi S, Kushwah R, Abdullah Alsibani M, El Jery A, Aldrdery M, Ashraf GA. Al-Sulaimi S, et al. Molecules. 2023 Aug 22;28(17):6175. doi: 10.3390/molecules28176175. Molecules. 2023. PMID: 37687004 Free PMC article. Review.
Capillary electrophoresis (CE) has emerged as a powerful technique for the analysis of chiral drugs. This review also highlights the significance of CE in chiral drug analysis, emphasizing its high separation efficiency, rapid analysis times, and compa …
Capillary electrophoresis (CE) has emerged as a powerful technique for the analysis of chiral drugs. This review also highligh …
Principles of pharmacoeconomics and their impact on strategic imperatives of pharmaceutical research and development.
Bodrogi J, Kaló Z. Bodrogi J, et al. Br J Pharmacol. 2010 Apr;159(7):1367-73. doi: 10.1111/j.1476-5381.2009.00550.x. Epub 2010 Feb 2. Br J Pharmacol. 2010. PMID: 20132213 Free PMC article. Review.
The need for pharmacoeconomic evidence has fundamentally changed the strategic imperatives of research and development (R&D). Therefore, professionals in pharmaceutical R&D have to be familiar with the principles of pharmacoeconomics, including the selection …
The need for pharmacoeconomic evidence has fundamentally changed the strategic imperatives of research and development (R&D). The …
Metabolomics in pharmaceutical research and development.
Puchades-Carrasco L, Pineda-Lucena A. Puchades-Carrasco L, et al. Curr Opin Biotechnol. 2015 Dec;35:73-7. doi: 10.1016/j.copbio.2015.04.004. Epub 2015 Apr 17. Curr Opin Biotechnol. 2015. PMID: 25900094 Review.
Metabolomics has significant potential in pharmaceutical and clinical research, including the identification of new targets, the elucidation of the mechanism of action of new drugs, the characterization of safety and efficacy profiles, as well as the discovery of bi …
Metabolomics has significant potential in pharmaceutical and clinical research, including the identification of new targets, t …
Proteomics in pharmaceutical research and development.
Cutler P, Voshol H. Cutler P, et al. Proteomics Clin Appl. 2015 Aug;9(7-8):643-50. doi: 10.1002/prca.201400181. Epub 2015 May 26. Proteomics Clin Appl. 2015. PMID: 25763573 Review.
In the 20 years since its inception, the evolution of proteomics in pharmaceutical industry has mirrored the developments within academia and indeed other industries. ...Nowadays, proteomics technologies have been integrated in many areas of pharmaceutical R&D, …
In the 20 years since its inception, the evolution of proteomics in pharmaceutical industry has mirrored the developments within acad …
Barriers and Facilitators of Pharmacoeconomic Studies: A Review of Evidence from the Middle Eastern Countries.
Alzarea AI, Khan YH, Alanazi AS, Butt MH, Almalki ZS, AlAhmari AK, Alsahali S, Mallhi TH. Alzarea AI, et al. Int J Environ Res Public Health. 2022 Jun 27;19(13):7862. doi: 10.3390/ijerph19137862. Int J Environ Res Public Health. 2022. PMID: 35805521 Free PMC article. Review.
The main facilitators were the availability of pharmacoeconomic guidelines, the encouragement of pharmacoeconomic experts and the promotion of group discussions and collaborations between researchers and policymakers. Cost-benefit analysis is still evolving in Middl …
The main facilitators were the availability of pharmacoeconomic guidelines, the encouragement of pharmacoeconomic experts and the promotion …
A review of bioanalytical applications of microextraction techniques combined with derivatization.
Manousi N, Ntorkou M, Tzanavaras PD, Zacharis CK. Manousi N, et al. Bioanalysis. 2023 Aug;15(15):937-954. doi: 10.4155/bio-2023-0121. Epub 2023 Aug 28. Bioanalysis. 2023. PMID: 37638635 Review.
Microextraction techniques have attracted the attention of many researchers working in the field of bioanalysis due to their unique advantages, mainly in downsizing the scale of sample preparation steps. In parallel, analytical derivatization offers a powerful combination …
Microextraction techniques have attracted the attention of many researchers working in the field of bioanalysis due to their unique a …
Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.
Yamashita T, Takayama K, Hori M, Harada-Shiba M, Mizuguchi H. Yamashita T, et al. Biol Pharm Bull. 2019;42(3):312-318. doi: 10.1248/bpb.b18-00544. Biol Pharm Bull. 2019. PMID: 30828061 Free article. Review.
It is also possible to identify the genetic mutations responsible for undiagnosed liver diseases using iPS cell and genome editing technologies. Finally, a combination of exhaustive analysis, iPS cells, and genome editing technologies would be a powerful approach to accele …
It is also possible to identify the genetic mutations responsible for undiagnosed liver diseases using iPS cell and genome editing technolog …
Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research.
Fatta-Kassinos D, Meric S, Nikolaou A. Fatta-Kassinos D, et al. Anal Bioanal Chem. 2011 Jan;399(1):251-75. doi: 10.1007/s00216-010-4300-9. Epub 2010 Nov 10. Anal Bioanal Chem. 2011. PMID: 21063687 Review.
Over the last decade the scientific community has embraced research in this specific field and the outcome has been immense. This was facilitated by advances in chromatographic techniques and relevant biological assays. Despite this, a number of unanswered questions exist …
Over the last decade the scientific community has embraced research in this specific field and the outcome has been immense. This was …
Reporting of covariate selection and balance assessment in propensity score analysis is suboptimal: a systematic review.
Ali MS, Groenwold RH, Belitser SV, Pestman WR, Hoes AW, Roes KC, Boer Ad, Klungel OH. Ali MS, et al. J Clin Epidemiol. 2015 Feb;68(2):112-21. doi: 10.1016/j.jclinepi.2014.08.011. Epub 2014 Nov 26. J Clin Epidemiol. 2015. PMID: 25433444 Review.
OBJECTIVES: To assess the current practice of propensity score (PS) analysis in the medical literature, particularly the assessment and reporting of balance on confounders. ...RESULTS: Among 296 articles that were included in the review, variable selection for PS mo …
OBJECTIVES: To assess the current practice of propensity score (PS) analysis in the medical literature, particularly the assessment a …
An informatics framework for the standardized collection and analysis of medication data in networked research.
Richesson RL. Richesson RL. J Biomed Inform. 2014 Dec;52:4-10. doi: 10.1016/j.jbi.2014.01.002. Epub 2014 Jan 14. J Biomed Inform. 2014. PMID: 24434192 Free article. Review.
This paper reviews approaches to coding medication data in multi-site research contexts, and proposes a framework for the classification, reporting, and analysis of medication data. The framework can be used to develop tools for classifying medications in coded data …
This paper reviews approaches to coding medication data in multi-site research contexts, and proposes a framework for the classificat …
A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.
Chen L, Dean B, Liang X. Chen L, et al. Drug Discov Today Technol. 2021 Dec;40:69-75. doi: 10.1016/j.ddtec.2021.10.002. Epub 2021 Oct 27. Drug Discov Today Technol. 2021. PMID: 34916026 Review.
In this paper, we review the growing development and applications of supercritical fluid chromatography-mass spectrometry (SFC-MS) for the analysis of small molecular analytes and biomarkers in drug discovery. ...In the second part of this review, we highligh …
In this paper, we review the growing development and applications of supercritical fluid chromatography-mass spectrometry (SFC-MS) fo …
[Translated article] Medication experience and clinical interventions in patients receiving pharmaceutical care: A scoping review of pharmaceutical care practice.
Orozco-Solano S, Silva-Castro MM, Machuca M. Orozco-Solano S, et al. Farm Hosp. 2023 Sep-Oct;47(5):T230-T242. doi: 10.1016/j.farma.2023.07.001. Epub 2023 Aug 31. Farm Hosp. 2023. PMID: 37659906 Free article. Review. English, Spanish.
OBJECTIVE: Analyze scientific literature on qualitative research that studies the medication experience-MedExp-and related pharmaceutical interventions that bring changes in patients' health. Through the content analysis of this scoping review, we inte …
OBJECTIVE: Analyze scientific literature on qualitative research that studies the medication experience-MedExp-and related pharmac …
Technologies and Standardization in Research on Extracellular Vesicles.
Gandham S, Su X, Wood J, Nocera AL, Alli SC, Milane L, Zimmerman A, Amiji M, Ivanov AR. Gandham S, et al. Trends Biotechnol. 2020 Oct;38(10):1066-1098. doi: 10.1016/j.tibtech.2020.05.012. Epub 2020 Jun 18. Trends Biotechnol. 2020. PMID: 32564882 Free PMC article. Review.
Potential applications of EVs in novel diagnostic and therapeutic strategies have brought increasing attention. However, EV research remains highly challenging due to the inherently complex biogenesis of EVs and their vast heterogeneity in size, composition, and origin. Th …
Potential applications of EVs in novel diagnostic and therapeutic strategies have brought increasing attention. However, EV research …
Decision-making in product portfolios of pharmaceutical research and development--managing streams of innovation in highly regulated markets.
Jekunen A. Jekunen A. Drug Des Devel Ther. 2014 Oct 21;8:2009-16. doi: 10.2147/DDDT.S68579. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 25364229 Free PMC article. Review.
The paper investigates decision-making in the industry and specifically in the development of oncology drugs from various perspectives: the need for decisions, their timing, decision-making at the project level, the optimal portfolio, tools for portfolio analysis, the eval …
The paper investigates decision-making in the industry and specifically in the development of oncology drugs from various perspectives: the …
Burning issues in the meta-analysis of pharmaceutical trials for depression.
Fountoulakis KN, Samara MT, Siamouli M. Fountoulakis KN, et al. J Psychopharmacol. 2014 Feb;28(2):106-17. doi: 10.1177/0269881113504014. Epub 2013 Sep 16. J Psychopharmacol. 2014. PMID: 24043723 Review.
The current article comments on problems within the randomized controlled trials design, the study samples, the psychometric scales, the methods of meta-analysis, the interpretation of the results, and the reporting of conflicts of interest. ...In the future it is importan …
The current article comments on problems within the randomized controlled trials design, the study samples, the psychometric scales, the met …
Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics.
Srivastava A, Creek DJ. Srivastava A, et al. Proteomics. 2019 May;19(10):e1700448. doi: 10.1002/pmic.201700448. Epub 2018 Nov 26. Proteomics. 2019. PMID: 30353665 Review.
This review highlights advances in proteomics technologies that have enabled high rates of discovery of candidate cancer biomarkers and evaluates integration with other omics technologies to improve their progress through to validation and clinical translation. Furthermore …
This review highlights advances in proteomics technologies that have enabled high rates of discovery of candidate cancer biomarkers a …
Cost-effectiveness research in cancer therapy: a systematic review of literature trends, methods and the influence of funding.
Al-Badriyeh D, Alameri M, Al-Okka R. Al-Badriyeh D, et al. BMJ Open. 2017 Jan 27;7(1):e012648. doi: 10.1136/bmjopen-2016-012648. BMJ Open. 2017. PMID: 28131999 Free PMC article. Review.
DESIGN: Systematic review. SETTING: A wide range of cancer-related research settings within healthcare, including health systems, hospitals and medical centres. ...PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcomes are the literature trends in relation to j …
DESIGN: Systematic review. SETTING: A wide range of cancer-related research settings within healthcare, including health syste …
Illicit Online Pharmacies: A Scoping Review.
Limbu YB, Huhmann BA. Limbu YB, et al. Int J Environ Res Public Health. 2023 May 8;20(9):5748. doi: 10.3390/ijerph20095748. Int J Environ Res Public Health. 2023. PMID: 37174265 Free PMC article. Review.
This scoping review presents the extent and nature of the body of literature on illicit online pharmacies (IOPs) and identifies research gaps. ...Data collection has been dominated by convenience sampling, online searches, content analysis and surveys. Data …
This scoping review presents the extent and nature of the body of literature on illicit online pharmacies (IOPs) and identifies re …
The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis.
Meid AD, Lampert A, Burnett A, Seidling HM, Haefeli WE. Meid AD, et al. Br J Clin Pharmacol. 2015 Oct;80(4):768-76. doi: 10.1111/bcp.12657. Epub 2015 Jun 12. Br J Clin Pharmacol. 2015. PMID: 25868941 Free PMC article. Review.
AIMS: The aim of the present study was to conduct a meta-analysis of controlled trials assessing the impact of pharmaceutical care interventions (e.g. medication reviews) on medication underuse in older patients (65 years). ...Results from reported outcomes were syn …
AIMS: The aim of the present study was to conduct a meta-analysis of controlled trials assessing the impact of pharmaceutical …
R&D efficiency of leading pharmaceutical companies - A 20-year analysis.
Schuhmacher A, Wilisch L, Kuss M, Kandelbauer A, Hinder M, Gassmann O. Schuhmacher A, et al. Drug Discov Today. 2021 Aug;26(8):1784-1789. doi: 10.1016/j.drudis.2021.05.005. Epub 2021 May 19. Drug Discov Today. 2021. PMID: 34022459 Review.
Comparative analysis of the R&D efficiency of 14 leading pharmaceutical companies for the years 1999-2018 shows that there is a close positive correlation between R&D spending and the two investigated R&D output parameters, approved NMEs and the cumulati …
Comparative analysis of the R&D efficiency of 14 leading pharmaceutical companies for the years 1999-2018 shows that there …
[Maintenance of Clinical Expertise and Clinical Research by the Clinical Professors at Gifu Pharmaceutical University].
Tachi T, Noguchi Y, Teramachi H. Tachi T, et al. Yakugaku Zasshi. 2017;137(1):3-8. doi: 10.1248/yakushi.16-00220-1. Yakugaku Zasshi. 2017. PMID: 28049892 Free article. Review. Japanese.
The clinical professors at Gifu Pharmaceutical University (GPU) provide pharmaceutical services at GPU Pharmacy, Gifu University Hospital, and Gifu Municipal Hospital to keep their clinical skills up-to-date; they also perform clinical research in collaborati …
The clinical professors at Gifu Pharmaceutical University (GPU) provide pharmaceutical services at GPU Pharmacy, Gifu Universi …
Reporting adherence, validity and physical activity measures of wearable activity trackers in medical research: A systematic review.
Chan A, Chan D, Lee H, Ng CC, Yeo AHL. Chan A, et al. Int J Med Inform. 2022 Apr;160:104696. doi: 10.1016/j.ijmedinf.2022.104696. Epub 2022 Jan 31. Int J Med Inform. 2022. PMID: 35121356 Free article. Review.
BACKGROUND: Wearable activity trackers are gaining traction in medical research, providing both real-time and remote monitoring of physical fitness. ...Most studies defined a valid day as wear-time of at least 10 h within 1 day (n = 10, 37%), and a valid interval as a week …
BACKGROUND: Wearable activity trackers are gaining traction in medical research, providing both real-time and remote monitoring of ph …
"Omics" in pharmaceutical research: overview, applications, challenges, and future perspectives.
Yan SK, Liu RH, Jin HZ, Liu XR, Ye J, Shan L, Zhang WD. Yan SK, et al. Chin J Nat Med. 2015 Jan;13(1):3-21. doi: 10.1016/S1875-5364(15)60002-4. Chin J Nat Med. 2015. PMID: 25660284 Review.
In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields o …
In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, prot …
Understanding and applying pharmacometric modelling and simulation in clinical practice and research.
Standing JF. Standing JF. Br J Clin Pharmacol. 2017 Feb;83(2):247-254. doi: 10.1111/bcp.13119. Epub 2016 Sep 29. Br J Clin Pharmacol. 2017. PMID: 27567102 Free PMC article. Review.
This includes modelling to understand the dose-response in preclinical studies, deriving a safe dose for first-in-man, and the overall analysis of Phase I/II data to optimise the dose for safety and efficacy in Phase III pivotal trials. ...This paper reviews fundamental PK …
This includes modelling to understand the dose-response in preclinical studies, deriving a safe dose for first-in-man, and the overall an …
Examining the use of network meta-analysis in pharmacy services research: A systematic review.
Teoh KW, Khan TM, Chaiyakunapruk N, Lee SWH. Teoh KW, et al. J Am Pharm Assoc (2003). 2019 Nov-Dec;59(6):787-791.e1. doi: 10.1016/j.japh.2019.06.015. Epub 2019 Jul 13. J Am Pharm Assoc (2003). 2019. PMID: 31311758
DATA SOURCES: A systematic literature review of network meta-analyses examining pharmacy services was performed on PubMed, Embase, International Pharmaceutical Abstracts, and Cochrane Database of Systematic Reviews from database inception to November 30, 2018. ...CO …
DATA SOURCES: A systematic literature review of network meta-analyses examining pharmacy services was performed on PubMed, Embase, In …
Critical analysis of the pharmaceutical care research literature.
Kennie NR, Schuster BG, Einarson TR. Kennie NR, et al. Ann Pharmacother. 1998 Jan;32(1):17-26. doi: 10.1177/106002809803200101. Ann Pharmacother. 1998. PMID: 9475815 Review.
OBJECTIVE: To describe and evaluate published pharmaceutical care research and make recommendations to improve the quality of the literature. DATA SOURCES: MEDLINE and International Pharmaceutical Abstracts using the key word "pharmaceutical care," lim …
OBJECTIVE: To describe and evaluate published pharmaceutical care research and make recommendations to improve the quality of …
Moyamoya Disease: A Review of Clinical Research.
Hishikawa T, Sugiu K, Date I. Hishikawa T, et al. Acta Med Okayama. 2016 Aug;70(4):229-36. doi: 10.18926/AMO/54497. Acta Med Okayama. 2016. PMID: 27549666 Free article. Review.
In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activit …
In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, su …
Statistical analysis in pharmacoeconomic studies. A review of current issues and standards.
Coyle D. Coyle D. Pharmacoeconomics. 1996 Jun;9(6):506-16. doi: 10.2165/00019053-199609060-00005. Pharmacoeconomics. 1996. PMID: 10160478 Review.
Such recommendations specifically relate to the level of testing that is conducted, the choice of statistical tests and the manner in which statistical significance is reported. In addition, existing methods for the statistical analysis of cost-effectiveness ratios and for …
Such recommendations specifically relate to the level of testing that is conducted, the choice of statistical tests and the manner in which …
An appraisal of meta-analysis guidelines: how do they relate to safety outcomes?
Bennetts M, Whalen E, Ahadieh S, Cappelleri JC. Bennetts M, et al. Res Synth Methods. 2017 Mar;8(1):64-78. doi: 10.1002/jrsm.1219. Epub 2016 Sep 9. Res Synth Methods. 2017. PMID: 27612447 Review.
A number of gaps in the current quality guidelines are identified along with issues to consider when performing a safety meta-analysis. While some work is ongoing to provide guidance to improve the quality of safety meta-analyses, this review emphasizes the critical …
A number of gaps in the current quality guidelines are identified along with issues to consider when performing a safety meta-analysis …
Strategies and settings of clinical pharmacogenetic implementation: a scoping review of pharmacogenetics programs.
Luczak T, Brown SJ, Armbruster D, Hundertmark M, Brown J, Stenehjem D. Luczak T, et al. Pharmacogenomics. 2021 Apr;22(6):345-364. doi: 10.2217/pgs-2020-0181. Epub 2021 Apr 8. Pharmacogenomics. 2021. PMID: 33829852 Review.
Forty articles representing 19 clinical PGx programs were included in analysis. Most programs are in urban, academic institutions. Education, governance and workflow were commonly described while billing/reimbursement and consent were not. This review provides an ov …
Forty articles representing 19 clinical PGx programs were included in analysis. Most programs are in urban, academic institutions. Ed …
Effect of pharmaceutical care on the treatment of COVID-19: A protocol for systematic review and meta analysis.
Niu J, Chen H, Chen K, Liu Y, Ju F, Xue T, Yin D, Li C, Yin C, Jiao L, Zhao G, Huang J. Niu J, et al. Medicine (Baltimore). 2020 Nov 25;99(48):e23377. doi: 10.1097/MD.0000000000023377. Medicine (Baltimore). 2020. PMID: 33235111 Free PMC article.
METHODS: All case-controlled studies related to pharmaceutical care on the treatment of COVID-19 will be included in this review. ...SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO CRD42020214223 ETHICS AND DISSEMINATION:: There is no need for ethical approva …
METHODS: All case-controlled studies related to pharmaceutical care on the treatment of COVID-19 will be included in this review …
Reagent Validation to Facilitate Experimental Reproducibility.
Williams M. Williams M. Curr Protoc Pharmacol. 2018 Jun;81(1):e40. doi: 10.1002/cpph.40. Epub 2018 May 16. Curr Protoc Pharmacol. 2018. PMID: 29927084 Review.
Many results reported in the biomedical research literature cannot be independently reproduced, undermining the basic foundations of science. ...These may result in flawed experimental design and execution that reflect a lack of planning, leading to an underpowering of a s …
Many results reported in the biomedical research literature cannot be independently reproduced, undermining the basic foundations of …
A systematic review of how missing data are handled and reported in multi-database pharmacoepidemiologic studies.
Hunt NB, Gardarsdottir H, Bazelier MT, Klungel OH, Pajouheshnia R. Hunt NB, et al. Pharmacoepidemiol Drug Saf. 2021 Jul;30(7):819-826. doi: 10.1002/pds.5245. Epub 2021 May 7. Pharmacoepidemiol Drug Saf. 2021. PMID: 33834576 Free PMC article. Review.
Thirty-five (56%) articles reported missing data: 11 of these studies reported that this could have introduced bias and 19 studies reported a method to address missing data. Thirteen (68%) carried out a complete case analysis, 2 (11%) applied multiple imputation, 2 (11%) u …
Thirty-five (56%) articles reported missing data: 11 of these studies reported that this could have introduced bias and 19 studies reported …
A comprehensive review on polyelectrolyte complexes.
Meka VS, Sing MKG, Pichika MR, Nali SR, Kolapalli VRM, Kesharwani P. Meka VS, et al. Drug Discov Today. 2017 Nov;22(11):1697-1706. doi: 10.1016/j.drudis.2017.06.008. Epub 2017 Jul 3. Drug Discov Today. 2017. PMID: 28683256 Review.
Global research on polyelectrolytes at a fundamental and applied level is intensifying because the advantages of sustainability are being accepted in academia and industrial research settings. ...Ionized polyelectrolytes in solution can form a complex with oppositel …
Global research on polyelectrolytes at a fundamental and applied level is intensifying because the advantages of sustainability are b …
Characteristics of post hoc subgroup analyses of oncology clinical trials: a systematic review.
Alrawabdeh J, Alzu'bi M, Alzyoud M, Odeh N, Hamadneh Y, Mian H, Mohyuddin GR, Kelkar AH, Goodman AM, Chakraborty R, Russler-Germain DA, Mehra N, Baggio D, Cliff ERS, Al Hadidi S. Alrawabdeh J, et al. JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad100. doi: 10.1093/jncics/pkad100. JNCI Cancer Spectr. 2023. PMID: 38006333 Free PMC article.
This study examined the prevalence and characteristics of post hoc subgroup analysis in oncology. METHODS: We systematically reviewed published subgroup analyses from 2000 to 2022. ...CONCLUSIONS: This study demonstrates the rapidly growing use of post hoc subgroup anal …
This study examined the prevalence and characteristics of post hoc subgroup analysis in oncology. METHODS: We systematically reviewed …
Hydrodynamic gene delivery and its applications in pharmaceutical research.
Bonamassa B, Hai L, Liu D. Bonamassa B, et al. Pharm Res. 2011 Apr;28(4):694-701. doi: 10.1007/s11095-010-0338-9. Epub 2010 Dec 30. Pharm Res. 2011. PMID: 21191634 Free PMC article. Review.
The procedure was initially established for gene delivery in mice, and its applications have been extended to the delivery of proteins, oligo nucleotides, genomic DNA and RNA sequences, and small molecules. The focus of this review is on applications of hydrodynamic delive …
The procedure was initially established for gene delivery in mice, and its applications have been extended to the delivery of proteins, olig …
Adaptive Design: A Review of the Technical, Statistical, and Regulatory Aspects of Implementation in a Clinical Trial.
Cerqueira FP, Jesus AMC, Cotrim MD. Cerqueira FP, et al. Ther Innov Regul Sci. 2020 Jan;54(1):246-258. doi: 10.1007/s43441-019-00052-y. Epub 2020 Jan 6. Ther Innov Regul Sci. 2020. PMID: 32008232 Review.
We selected variables extracted from trials that included basic study characteristics, adaptive design features, size and use of independent data-monitoring committees (DMCs), and blinded interim analysis. RESULTS: The research retrieved 336 results, from which 78 w …
We selected variables extracted from trials that included basic study characteristics, adaptive design features, size and use of independent …
Nano-liquid chromatography in pharmaceutical and biomedical research.
Gama MR, Collins CH, Bottoli CB. Gama MR, et al. J Chromatogr Sci. 2013 Aug;51(7):694-703. doi: 10.1093/chromsci/bmt023. Epub 2013 Apr 12. J Chromatogr Sci. 2013. PMID: 23585638 Review.
Furthermore, the low levels of analytes, especially in biological samples, promote the search for more highly sensitive techniques; coupled to mass spectrometry, nano-LC has great potential to become an indispensable tool for routine analysis of biomolecules. This short …
Furthermore, the low levels of analytes, especially in biological samples, promote the search for more highly sensitive techniques; coupled …
Conflicts of interest and industry professional relationships in psychiatric neurosurgery: a comparative literature review.
Cabrera LY, Boyce HMK, McKenzie R, Bluhm R. Cabrera LY, et al. Neurosurg Focus. 2018 Aug;45(2):E20. doi: 10.3171/2018.4.FOCUS17399. Neurosurg Focus. 2018. PMID: 30064327 Review.
OBJECTIVE The research required to establish that psychiatric treatments are effective often depends on collaboration between academic clinical researchers and industry. ...METHODS The authors conducted a study focused on professional concerns regarding pharmacologi …
OBJECTIVE The research required to establish that psychiatric treatments are effective often depends on collaboration between academi …
Metabolomics: Going Deeper, Going Broader, Going Further.
Moco S, Buescher JM. Moco S, et al. Methods Mol Biol. 2023;2554:155-178. doi: 10.1007/978-1-0716-2624-5_11. Methods Mol Biol. 2023. PMID: 36178626 Review.
Metabolomics is a continuously dynamic field of research that is driven by demanding research questions and technological advances alike. In this review we highlight selected recent and ongoing developments in the area of mass spectrometry-based metabolomics. …
Metabolomics is a continuously dynamic field of research that is driven by demanding research questions and technological adva …
Interpreting the results of noninferiority trials-a review.
Cuzick J, Sasieni P. Cuzick J, et al. Br J Cancer. 2022 Nov;127(10):1755-1759. doi: 10.1038/s41416-022-01937-w. Epub 2022 Sep 15. Br J Cancer. 2022. PMID: 36104512 Free PMC article. Review.
., no significant difference), or even significantly inferior in a conventional analysis. Noninferiority comparisons are an important addition to the reporting of clinical trials, but require prior consideration of several factors that conventional superiority analyses do …
., no significant difference), or even significantly inferior in a conventional analysis. Noninferiority comparisons are an important …
Advancing the development of real-world data for healthcare research in China: challenges and opportunities.
Zhong J, Zhang J, Fang H, Liu L, Xie J, Wu E. Zhong J, et al. BMJ Open. 2022 Jul 29;12(7):e063139. doi: 10.1136/bmjopen-2022-063139. BMJ Open. 2022. PMID: 35906059 Free PMC article. Review.
Despite these efforts, significant barriers remain that hinder high-quality healthcare research. A workshop with 30 representatives from healthcare research agencies, technology companies focused on healthcare big data and pharmaceutical companies was held in …
Despite these efforts, significant barriers remain that hinder high-quality healthcare research. A workshop with 30 representatives f …
Analysis of information flows in interaction networks: implication for drug discovery and pharmacological research.
Fliri AF, Loging WT, Volkmann RA. Fliri AF, et al. Discov Med. 2011 Feb;11(57):133-43. Discov Med. 2011. PMID: 21356168 Free article. Review.
Despite the longstanding realization that clinical and preclinical drug-effect information needs to be integrated for generating more accurate forecasts of drug-effects, a road map for linking these disparate sources of information currently does not exist. This review foc …
Despite the longstanding realization that clinical and preclinical drug-effect information needs to be integrated for generating more accura …
UPLC-MS for metabolomics: a giant step forward in support of pharmaceutical research.
Nassar AF, Wu T, Nassar SF, Wisnewski AV. Nassar AF, et al. Drug Discov Today. 2017 Feb;22(2):463-470. doi: 10.1016/j.drudis.2016.11.020. Epub 2016 Dec 2. Drug Discov Today. 2017. PMID: 27919805 Free PMC article. Review.
This review seeks to provide the reader with a brief history of the development of metabolomics, its significance and strategies for conducting metabolomics studies. The most widely used analytical tools for metabolomics: NMR, LC-MS and GC-MS, are discussed along with cons …
This review seeks to provide the reader with a brief history of the development of metabolomics, its significance and strategies for …
Bayesian Statistics for Medical Devices: Progress Since 2010.
Campbell G, Irony T, Pennello G, Thompson L. Campbell G, et al. Ther Innov Regul Sci. 2023 May;57(3):453-463. doi: 10.1007/s43441-022-00495-w. Epub 2023 Mar 3. Ther Innov Regul Sci. 2023. PMID: 36869194 Free PMC article. Review.
The use of Bayesian statistics to support regulatory evaluation of medical devices began in the late 1990s. We review the literature, focusing on recent developments of Bayesian methods, including hierarchical modeling of studies and subgroups, borrowing strength from prio …
The use of Bayesian statistics to support regulatory evaluation of medical devices began in the late 1990s. We review the literature, …
Review of Scientific Self-Experimentation: Ethics History, Regulation, Scenarios, and Views Among Ethics Committees and Prominent Scientists.
Hanley BP, Bains W, Church G. Hanley BP, et al. Rejuvenation Res. 2019 Feb;22(1):31-42. doi: 10.1089/rej.2018.2059. Epub 2018 Aug 8. Rejuvenation Res. 2019. PMID: 29926769 Review.
We discuss real-world scenarios of self-experimentation: at universities, for independent single-subject investigators, investigator/employees at pharmaceutical firms, and nonscientist self-experimenters. Our survey of ethics committees regarding policy and review f …
We discuss real-world scenarios of self-experimentation: at universities, for independent single-subject investigators, investigator/employe …
Current application and potential use of GC GC in the pharmaceutical and biomedical field.
Aspromonte J, Wolfs K, Adams E. Aspromonte J, et al. J Pharm Biomed Anal. 2019 Nov 30;176:112817. doi: 10.1016/j.jpba.2019.112817. Epub 2019 Aug 18. J Pharm Biomed Anal. 2019. PMID: 31450070 Review.
The analysis of volatile samples is mostly performed by GC. However, its separation power may not be enough for some complex samples. ...Nonetheless, it is still often seen as a novelty, thus being rarely considered a fully established technique for routine analysis …
The analysis of volatile samples is mostly performed by GC. However, its separation power may not be enough for some complex samples. …
Practical utility of mixed methods research in pharmacy practice.
Dalpoas SE, Shermock KM. Dalpoas SE, et al. Am J Health Syst Pharm. 2021 Nov 9;78(22):2033-2039. doi: 10.1093/ajhp/zxab232. Am J Health Syst Pharm. 2021. PMID: 34077491 Review.
PURPOSE: Our aim was to review key methodological concepts and provide a practical guide to employing mixed methods research to enhance pharmacy practice research. ...For research questions that benefit from mixed methods research, we review …
PURPOSE: Our aim was to review key methodological concepts and provide a practical guide to employing mixed methods research t …
Application of solid-phase microextraction in current biomedical research.
Roszkowska A, Miękus N, Bączek T. Roszkowska A, et al. J Sep Sci. 2019 Jan;42(1):285-302. doi: 10.1002/jssc.201800785. Epub 2018 Oct 25. J Sep Sci. 2019. PMID: 30289623 Review.
For example, solid-phase microextraction is particularly useful for identifying biomarkers in metabolomics studies, and it can be successfully applied in pharmaceutical and toxicological studies requiring the fast and sensitive determination of drug levels, especially thos …
For example, solid-phase microextraction is particularly useful for identifying biomarkers in metabolomics studies, and it can be successful …
Automated and enabling technologies for medicinal chemistry.
Nichols PL. Nichols PL. Prog Med Chem. 2021;60:191-272. doi: 10.1016/bs.pmch.2021.01.003. Epub 2021 Jun 7. Prog Med Chem. 2021. PMID: 34147203 Review.
Having always been driven by the need to get new treatments to patients as quickly as possible, drug discovery is a constantly evolving process. This chapter will review how medicinal chemistry was established, how it has changed over the years due to the emergence of new …
Having always been driven by the need to get new treatments to patients as quickly as possible, drug discovery is a constantly evolving proc …
Cyclodextrins Based Electrochemical Sensors for Biomedical and Pharmaceutical Analysis.
Lenik J. Lenik J. Curr Med Chem. 2017;24(22):2359-2391. doi: 10.2174/0929867323666161213101407. Curr Med Chem. 2017. PMID: 27978804 Review.
The process of preparing of CDs modified electrodes would, consequently, open new avenues for new electrochemical sensors and, therefore, widen their use in biomedical and drug analysis. This review presents information on manufacturing techniques and performances o …
The process of preparing of CDs modified electrodes would, consequently, open new avenues for new electrochemical sensors and, therefore, wi …
Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives.
Grangeia HB, Silva C, Simões SP, Reis MS. Grangeia HB, et al. Eur J Pharm Biopharm. 2020 Feb;147:19-37. doi: 10.1016/j.ejpb.2019.12.007. Epub 2019 Dec 17. Eur J Pharm Biopharm. 2020. PMID: 31862299
In this review, we aim to analyse the current state of implementation of QbD methodologies and tools in the pharmaceutical industry, extracting patterns and trends and identifying gaps and opportunities that may be considered to improve QbD adoption. For this purpos …
In this review, we aim to analyse the current state of implementation of QbD methodologies and tools in the pharmaceutical ind …
Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs.
Sung JH. Sung JH. Expert Opin Drug Metab Toxicol. 2021 Aug;17(8):969-986. doi: 10.1080/17425255.2021.1908996. Epub 2021 Apr 5. Expert Opin Drug Metab Toxicol. 2021. PMID: 33764248 Review.
Although conventional in vitro methods for predicting the PK and TK of drugs are well established, limitations still exist and more advanced chip-based in vitro platforms combined with mathematical models can help researchers overcome the limitations. Areas covered: We wil …
Although conventional in vitro methods for predicting the PK and TK of drugs are well established, limitations still exist and more advanced …
Effectiveness of horticultural therapy: a systematic review of randomized controlled trials.
Kamioka H, Tsutani K, Yamada M, Park H, Okuizumi H, Honda T, Okada S, Park SJ, Kitayuguchi J, Abe T, Handa S, Mutoh Y. Kamioka H, et al. Complement Ther Med. 2014 Oct;22(5):930-43. doi: 10.1016/j.ctim.2014.08.009. Epub 2014 Sep 1. Complement Ther Med. 2014. PMID: 25440385 Review.
These studies showed significant effectiveness in one or more outcomes for mental health and behavior. However, our review especially detected omissions of the following descriptions: method used to generate randomization, concealment, blinding, and intention-to-treat a …
These studies showed significant effectiveness in one or more outcomes for mental health and behavior. However, our review especially …
2020 in review: FDA approvals of new medicines.
Kinch MS, Kraft Z, Schwartz T. Kinch MS, et al. Drug Discov Today. 2021 Dec;26(12):2794-2799. doi: 10.1016/j.drudis.2021.07.003. Epub 2021 Jul 10. Drug Discov Today. 2021. PMID: 34252611 Review.
Orphan approvals also surged, capturing 60% of NMEs introduced during 2020, as did the number of NMEs approved using a priority review. The pandemic did appear to impact one recent trend, and in a paradoxically encouraging way. Escalating rates of consolidation slowed in 2 …
Orphan approvals also surged, capturing 60% of NMEs introduced during 2020, as did the number of NMEs approved using a priority review …
Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications.
Guo R, Guo G, Wang A, Xu G, Lai R, Jin H. Guo R, et al. Molecules. 2023 Dec 20;29(1):35. doi: 10.3390/molecules29010035. Molecules. 2023. PMID: 38202621 Free PMC article. Review.
Moreover, spider-venom peptides have emerged as valuable tools for exploring human disease mechanisms. This review focuses on the roles of spider-venom peptides in spider survival strategies and their dual significance as pharmaceutical research tools. By int …
Moreover, spider-venom peptides have emerged as valuable tools for exploring human disease mechanisms. This review focuses on the rol …
A state of the art in analytical quality-by-design and perspectives in characterization of nano-enabled medicinal products.
Bastogne T, Caputo F, Prina-Mello A, Borgos S, Barberi-Heyob M. Bastogne T, et al. J Pharm Biomed Anal. 2022 Sep 20;219:114911. doi: 10.1016/j.jpba.2022.114911. Epub 2022 Jun 24. J Pharm Biomed Anal. 2022. PMID: 35779356 Review.
Quality-by-Design (QbD) guidance is a risk-based and proactive approach to drug development proposed in the early 2000s and now widely used in the pharmaceutical field in compliance with the ICH Q8-Q11 guidelines. Analytical Quality by Design (AQbD), introduced in 2010, is …
Quality-by-Design (QbD) guidance is a risk-based and proactive approach to drug development proposed in the early 2000s and now widely used …
Advances in capillary electrophoresis for the life sciences.
Sastre Toraño J, Ramautar R, de Jong G. Sastre Toraño J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 15;1118-1119:116-136. doi: 10.1016/j.jchromb.2019.04.020. Epub 2019 Apr 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 31035134 Free article. Review.
Capillary electrophoresis (CE) played an important role in developments in the life sciences. The technique is nowadays used for the analysis of both large and small molecules in applications where it performs better than or is complementary to liquid chromatographic techn …
Capillary electrophoresis (CE) played an important role in developments in the life sciences. The technique is nowadays used for the anal …
An analysis of quality of systematic reviews on pharmacist health interventions.
Melchiors AC, Correr CJ, Venson R, Pontarolo R. Melchiors AC, et al. Int J Clin Pharm. 2012 Feb;34(1):32-42. doi: 10.1007/s11096-011-9592-0. Epub 2011 Dec 20. Int J Clin Pharm. 2012. PMID: 22183578 Review.
BACKGROUND: In the past 20 years, many studies have evaluated the impact of pharmaceutical practices on clinical, humanistic and economic outcomes. However, few studies have critically analysed the primary studies and published reviews regarding pharmaceutical pract …
BACKGROUND: In the past 20 years, many studies have evaluated the impact of pharmaceutical practices on clinical, humanistic and econ …
Productivity of authors in the field of diabetes: bibliographic analysis of trial publications.
Holleman F, Uijldert M, Donswijk LF, Gale EA. Holleman F, et al. BMJ. 2015 Jul 1;351:h2638. doi: 10.1136/bmj.h2638. BMJ. 2015. PMID: 26136272 Free PMC article. Review.
OBJECTIVE: To determine whether trial publications of glucose lowering drugs are dominated by a small group of highly prolific authors ("supertrialists") and to identify some of their characteristics. DESIGN: Bibliographic analysis of trial publications. DATA SOURCES AND …
OBJECTIVE: To determine whether trial publications of glucose lowering drugs are dominated by a small group of highly prolific authors ("sup …
Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development.
Schulz S, Becker M, Groseclose MR, Schadt S, Hopf C. Schulz S, et al. Curr Opin Biotechnol. 2019 Feb;55:51-59. doi: 10.1016/j.copbio.2018.08.003. Epub 2018 Aug 25. Curr Opin Biotechnol. 2019. PMID: 30153614 Free article. Review.
Recent advances in instrumentation, sample preparation, multimodal workflows, quantification, analytical standardization and 'big data' processing have led to widespread utilization of MALDI MSI in pharmaceutical research. These developments have led to applications …
Recent advances in instrumentation, sample preparation, multimodal workflows, quantification, analytical standardization and 'big data' proc …
Embracing model-based designs for dose-finding trials.
Love SB, Brown S, Weir CJ, Harbron C, Yap C, Gaschler-Markefski B, Matcham J, Caffrey L, McKevitt C, Clive S, Craddock C, Spicer J, Cornelius V. Love SB, et al. Br J Cancer. 2017 Jul 25;117(3):332-339. doi: 10.1038/bjc.2017.186. Epub 2017 Jun 29. Br J Cancer. 2017. PMID: 28664918 Free PMC article. Review.
CONCLUSIONS: There is overwhelming evidence for the benefits of CRM. Many leading pharmaceutical companies routinely implement model-based designs. Our analysis identified barriers for academic statisticians and clinical academics in mirroring the progress industry …
CONCLUSIONS: There is overwhelming evidence for the benefits of CRM. Many leading pharmaceutical companies routinely implement model- …
Data Integrity in the Pharmaceutical Industry: Analysis of Inspections and Warning Letters Issued by the Bioresearch Monitoring Program Between Fiscal Years 2007-2018.
Rogers CA, Ahearn JD, Bartlett MG. Rogers CA, et al. Ther Innov Regul Sci. 2020 Sep;54(5):1123-1133. doi: 10.1007/s43441-020-00129-z. Epub 2020 Feb 24. Ther Innov Regul Sci. 2020. PMID: 32096103 Free PMC article.
BACKGROUND: Warning Letters issued by the Food and Drug Administration's Bioresearch Monitoring (BIMO) Program provide insight into data integrity issues and other research misconduct in the premarket side of the pharmaceutical industry. The objectives of this study …
BACKGROUND: Warning Letters issued by the Food and Drug Administration's Bioresearch Monitoring (BIMO) Program provide insight into data int …
Flexible Bayesian subgroup analysis in early and confirmatory trials.
Bunn V, Liu R, Lin J, Lin J. Bunn V, et al. Contemp Clin Trials. 2020 Nov;98:106149. doi: 10.1016/j.cct.2020.106149. Epub 2020 Sep 15. Contemp Clin Trials. 2020. PMID: 32942055 Review.
Subgroup analysis is one of the most important issues in clinical trials. In confirmatory trials, it is critical to investigate consistency of the treatment effect across subgroups, which could potentially result in incorrect scientific conclusion or regulatory decision. . …
Subgroup analysis is one of the most important issues in clinical trials. In confirmatory trials, it is critical to investigate consi …
Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis.
Grotto D, Camargo IF, Kodaira K, Mazzei LG, Castro J, Vieira RAL, Bergamaschi CC, Lopes LC. Grotto D, et al. Syst Rev. 2019 Nov 26;8(1):288. doi: 10.1186/s13643-019-1205-3. Syst Rev. 2019. PMID: 31771635 Free PMC article.
A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias risk (using SYstematic Review Centre for Laboratory animal Experimentation SYRCLE's risk of bias tool and the Collaborative Approach …
A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias …
Basic concepts of artificial neural network (ANN) modeling and its application in pharmaceutical research.
Agatonovic-Kustrin S, Beresford R. Agatonovic-Kustrin S, et al. J Pharm Biomed Anal. 2000 Jun;22(5):717-27. doi: 10.1016/s0731-7085(99)00272-1. J Pharm Biomed Anal. 2000. PMID: 10815714 Review.
Unsupervised feature-extracting networks represent an alternative to principal component analysis. Non-adaptive unsupervised networks are able to reconstruct their patterns when presented with noisy samples and can be used for image recognition. The potential applications …
Unsupervised feature-extracting networks represent an alternative to principal component analysis. Non-adaptive unsupervised networks …
Narrative review: the promotion of gabapentin: an analysis of internal industry documents.
Steinman MA, Bero LA, Chren MM, Landefeld CS. Steinman MA, et al. Ann Intern Med. 2006 Aug 15;145(4):284-93. doi: 10.7326/0003-4819-145-4-200608150-00008. Ann Intern Med. 2006. PMID: 16908919 Free article. Review.
BACKGROUND: Internal documents from the pharmaceutical industry provide a unique window for understanding the structure and methods of pharmaceutical promotion. ...DATA EXTRACTION: All documents were reviewed by 1 author, with selected review by coauthors. Ma …
BACKGROUND: Internal documents from the pharmaceutical industry provide a unique window for understanding the structure and methods o …
[Research Using the Roter Method of Interaction Process Analysis (RIAS) for Communication Education in the Pharmaceutical Sciences].
Arita E. Arita E. Yakugaku Zasshi. 2017;137(6):665-669. doi: 10.1248/yakushi.16-00224-3. Yakugaku Zasshi. 2017. PMID: 28566570 Free article. Review. Japanese.
Only recently the importance of qualitative research has been recognized in pharmaceutical studies, a field in which any aspect difficult to express numerically has been considered subjective, and thus less acceptable. ...RIAS is a quantitative analysis of qu …
Only recently the importance of qualitative research has been recognized in pharmaceutical studies, a field in which any aspec …
The reporting characteristics and methodological quality of Cochrane reviews about health policy research.
Xiu-xia L, Ya Z, Yao-long C, Ke-hu Y, Zong-jiu Z. Xiu-xia L, et al. Health Policy. 2015 Apr;119(4):503-10. doi: 10.1016/j.healthpol.2014.09.002. Epub 2014 Sep 16. Health Policy. 2015. PMID: 25260911 Review.
The systematic review has increasingly become a popular tool for researching health policy. ...Only 39% conducted meta-analysis, and 49% reported being updates, and none was rated low methodological quality. ...
The systematic review has increasingly become a popular tool for researching health policy. ...Only 39% conducted meta-anal …
Environmental assessment of cytotoxic drugs in healthcare settings: protocol for a systematic review and meta-analysis.
Al Alawi L, Soteriades ES, Paulo MS, Östlundh L, Grivna M, Al Maskari F, Al-Rifai RH. Al Alawi L, et al. Syst Rev. 2020 Oct 19;9(1):242. doi: 10.1186/s13643-020-01494-4. Syst Rev. 2020. PMID: 33076972 Free PMC article.
BACKGROUND: Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify …
BACKGROUND: Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodo …
Methodological quality and risk of bias of meta-analyses of pharmacy services: A systematic review.
Bonetti AF, Tonin FS, Della Rocca AM, Lucchetta RC, Fernandez-Llimos F, Pontarolo R. Bonetti AF, et al. Res Social Adm Pharm. 2022 Mar;18(3):2403-2409. doi: 10.1016/j.sapharm.2020.12.011. Epub 2020 Dec 23. Res Social Adm Pharm. 2022. PMID: 33358399
BACKGROUND: A suboptimal meta-analysis with misleading conclusions, frequently published in the healthcare journals, can compromise decision making in clinical practice. ...
BACKGROUND: A suboptimal meta-analysis with misleading conclusions, frequently published in the healthcare journals, can compromise d …
Secondary patents in the pharmaceutical industry: missing the wood for the trees?
Kiran S, Kulkarni M. Kiran S, et al. Expert Opin Ther Pat. 2018 Mar;28(3):241-250. doi: 10.1080/13543776.2018.1424134. Epub 2018 Jan 7. Expert Opin Ther Pat. 2018. PMID: 29298119 Review.
INTRODUCTION: The critics of the Innovator pharmaceutical industry allege that secondary patents are trivial modifications over the primary patent, which extend its term and delay the entry of the generics in the market place. The protagonists regard secondary patents a re …
INTRODUCTION: The critics of the Innovator pharmaceutical industry allege that secondary patents are trivial modifications over the p …
Scientific, statistical, practical, and regulatory considerations in design space development.
Debevec V, Srčič S, Horvat M. Debevec V, et al. Drug Dev Ind Pharm. 2018 Mar;44(3):349-364. doi: 10.1080/03639045.2017.1409755. Epub 2017 Dec 19. Drug Dev Ind Pharm. 2018. PMID: 29200316 Review.
This review article presents scientific, statistical and regulatory considerations in design space development. All key development milestones, starting with planning, selection of factors, experimental execution, data analysis, model development and assessment, ver …
This review article presents scientific, statistical and regulatory considerations in design space development. All key development m …
The Trends and Hotspots in Premature Ovarian Insufficiency Therapy from 2000 to 2022.
Tong Y, Cheng N, Jiang X, Wang K, Wang F, Lin X, Wang F. Tong Y, et al. Int J Environ Res Public Health. 2022 Sep 17;19(18):11728. doi: 10.3390/ijerph191811728. Int J Environ Res Public Health. 2022. PMID: 36142002 Free PMC article. Review.
Fertility and Sterility and Nelson, L.M. were the most influential journal and author, respectively. Seven clusters separated by keywords association showed the extensive scope of POI therapy. ...The paper provides a comprehensive overview of the development and hotspots o …
Fertility and Sterility and Nelson, L.M. were the most influential journal and author, respectively. Seven clusters separated by keyw …
Role of pharmacists in the context of rare diseases: a scoping review protocol.
Cunico C, Leite SN. Cunico C, et al. BMJ Open. 2023 Nov 21;13(11):e072001. doi: 10.1136/bmjopen-2023-072001. BMJ Open. 2023. PMID: 37989368 Free PMC article.
No assessments of items' quality will be made, as the purpose of this scoping review is to synthesise and describe the coverage of the evidence. Clinical, humanistic or economic outcomes from studies that meet the inclusion criteria will be included in the review. T …
No assessments of items' quality will be made, as the purpose of this scoping review is to synthesise and describe the coverage of th …
The Failures of Ethnobotany and Phytomedicine in Delivering Novel Treatments for Snakebite Envenomation.
Trim SA, Trim CM, Williams HF, Vaiyapuri S. Trim SA, et al. Toxins (Basel). 2020 Dec 6;12(12):774. doi: 10.3390/toxins12120774. Toxins (Basel). 2020. PMID: 33291263 Free PMC article. Review.
Plants are a major source of bioactive molecules, including several lifesaving medications that are widely used to this day. However, much of the research into the use of traditional plant treatments for SBE are limited to preliminary analysis or have focused on tec …
Plants are a major source of bioactive molecules, including several lifesaving medications that are widely used to this day. However, much o …
Controversies surrounding authorship of manuscripts by industry employees: academic and industry perspectives.
Smilowitz NR, Ferguson JJ, Weisz G. Smilowitz NR, et al. EuroIntervention. 2018 Mar 20;13(16):1967-1974. doi: 10.4244/EIJ-D-16-00918. EuroIntervention. 2018. PMID: 29278351 Free article. Review.
Potential conflicts of interest in biomedical research have attracted significant attention in recent years, but issues and challenges surrounding authors who are industry employees have not received nearly as much scrutiny. ...Potential concerns include the effect of indu …
Potential conflicts of interest in biomedical research have attracted significant attention in recent years, but issues and challenge …
Obtaining and managing data sets for individual participant data meta-analysis: scoping review and practical guide.
Ventresca M, Schünemann HJ, Macbeth F, Clarke M, Thabane L, Griffiths G, Noble S, Garcia D, Marcucci M, Iorio A, Zhou Q, Crowther M, Akl EA, Lyman GH, Gloy V, DiNisio M, Briel M. Ventresca M, et al. BMC Med Res Methodol. 2020 May 12;20(1):113. doi: 10.1186/s12874-020-00964-6. BMC Med Res Methodol. 2020. PMID: 32398016 Free PMC article. Review.
We present short descriptions of these articles alongside overviews of IPD sharing policies and procedures of pharmaceutical companies which display certification of Principles for Responsible Clinical Trial Data Sharing via Pharmaceutical Research and Manufa …
We present short descriptions of these articles alongside overviews of IPD sharing policies and procedures of pharmaceutical companie …
Reproducibility, relevance and reliability as barriers to efficient and credible biomedical technology translation.
Dirnagl U, Duda GN, Grainger DW, Reinke P, Roubenoff R. Dirnagl U, et al. Adv Drug Deliv Rev. 2022 Mar;182:114118. doi: 10.1016/j.addr.2022.114118. Epub 2022 Jan 20. Adv Drug Deliv Rev. 2022. PMID: 35066104 Review.
Biomedical research accuracy and relevance for improving healthcare are increasingly identified as costly problems. ...Improving this biomedical research strategy and resourcing for reliability, translational relevance, reproducibility and clinical impact requires c …
Biomedical research accuracy and relevance for improving healthcare are increasingly identified as costly problems. ...Improving this …
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