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The role of molecular size in ligand efficiency.
Reynolds CH, Bembenek SD, Tounge BA. Reynolds CH, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4258-61. doi: 10.1016/j.bmcl.2007.05.038. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17532632
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: reynolds ch. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503
Ligand efficiency and fragment-based drug discovery.
Bembenek SD, Tounge BA, Reynolds CH. Bembenek SD, et al. Among authors: reynolds ch. Drug Discov Today. 2009 Mar;14(5-6):278-83. doi: 10.1016/j.drudis.2008.11.007. Epub 2008 Dec 30. Drug Discov Today. 2009. PMID: 19073276 Review.
111 results